Rchr
J-GLOBAL ID：201301063495929160
Update date: Mar. 02, 2024
Akihiro Yamashita
ヤマシタ アキヒロ | Akihiro Yamashita
Affiliation and department：
Homepage URL (1)：
http://kaken.nii.ac.jp/d/r/00636855.ja.html
Research field (3)：
Cell biology
, Regenerative dentistry and dental engineering
, Surgical dentistry
Research theme for competitive and other funds (4)：
- 2021 - 2025 ヒト3次元軟骨組織モデルによる新規軟骨特異的分子の同定と軟骨分化制御機構の解明
- 2018 - 2021 Elucidation of the function of cartilage membrane using iPSC-derived cartilage
- 2014 - 2017 Elucidation of disease mechanism and therapy of FGFR3 skeletal dysplasia using patient-derived iPSCs
- 2012 - 2014 Disease modeling and drug screening of thanatophooric dysplasia using reprogramming technology
Papers (36)：
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Kengo Abe, Akihiro Yamashita, Miho Morioka, Nanao Horike, Yoshiaki Takei, Saeko Koyamatsu, Keisuke Okita, Shuichi Matsuda, Noriyuki Tsumaki. Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect. Nature Communications. 2023. 14. 1
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Yuki Okutani, Kengo Abe, Akihiro Yamashita, Miho Morioka, Shuichi Matsuda, Noriyuki Tsumaki. Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell Surface. Tissue Engineering Part A. 2022. 28. 1-2. 94-106
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Wai Long Tam, Luís Freitas Mendes, Xike Chen, Raphaëlle Lesage, Inge Van Hoven, Elke Leysen, Greet Kerckhofs, Kathleen Bosmans, Yoke Chin Chai, Akihiro Yamashita, et al. Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects. Stem Cell Research & Therapy. 2021. 12. 1
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Akihiro Yamashita, Noriyuki Tsumaki. Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells. Development, Growth & Differentiation. 2021. 63. 1. 72-81
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Akihiro Yamashita, Hiroyuki Yoshitomi, Shunsuke Kihara, Junya Toguchida, Noriyuki Tsumaki. Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells. Stem cells translational medicine. 2021. 10. 1. 115-127
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MISC (11)：
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武井義明, 武井義明, 小林与人, 堀家なな緒, 森岡美帆, 高才東, 釜谷崇志, 山下晃弘, 竹森洋, 妻木範行. Salt inducible kinase 3 (SIK3) mediate shear stress-induced up-regulation of lubricin at the articular cartilage surface. 日本軟骨代謝学会プログラム・抄録集. 2020. 33rd
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小林与人, 小林与人, 山下晃弘, 森岡美帆, 釜谷崇志, 高才東, KNUT Woltjen, 松田秀一, 妻木範行. ヒトiPS細胞由来軟骨移植の安全性評価-ラット膝関節軟骨欠損モデルを用いて-. 日本軟骨代謝学会プログラム・抄録集. 2017. 30th
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木村武司, 木村武司, 安田紀恵, 窪田拓生, 三善陽子, 山下晃弘, 妻木範行, 大薗恵一. 疾患特異的ヒトiPS細胞を用いた内軟骨性骨化モデル. 日本小児内分泌学会学術集会プログラム・抄録集. 2017. 51st
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Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki. ESTABLISHMENT OF A HUMAN GROWTH PLATE MODEL WITH IPS CELL-DERIVED CARTILAGE. HORMONE RESEARCH IN PAEDIATRICS. 2017. 88. 9-10
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木村武司, 木村武司, 森岡美穂, 山下晃弘, 大薗恵一, 妻木範行. ヒトiPS細胞由来軟骨細胞の免疫原性の解析. 日本軟骨代謝学会プログラム・抄録集. 2016. 29th
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Lectures and oral presentations (14)：
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iPS細胞由来軟骨の移植による限局した関節軟骨損傷の再生治療研究
(関節病学会 2017)
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Regenerative treatment of focal defects of articular cartilage with iPS cell-derived cartilage
(APLAR 2016)
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ヒトiPS細胞由来軟骨の開発
(2016)
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ヒトiPS細胞由来軟骨を用いた関節軟骨再生治療の試み
(日本炎症・再生医学会 2016)
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スタチンによるFGFR3軟骨形成異常症の病態回復
(軟骨代謝学会 2016)
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Professional career (1)：
Work history (3)：
- 2021/07 - 現在 Osaka University Graduate School of Medicine
- 2015/07 - 2021/06 京都大学 iPS細胞研究所 特定拠点助教
- 2012 - 京都大学 iPS細胞研究所 特定研究員
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