KINOSHITA Chisato

キノシタチサト | KINOSHITA Chisato

Affiliation and department：

Research field (3)： Pharmacology , Genomics , Nervous system function

Research keywords (10)： NOVA1 , non-coding RNA , taurine , Circadian Rhythm , Neurodegenerative disease , RNA binding protein , GTRAP3-18 , EAAC1 , microRNA , Glutathione

Research theme for competitive and other funds (14)：

2023 - 2026 Analysis of novel peptide nucleic acids against neurodegeneration
2021 - 2024 マイクロバブル超音波法を用いた核酸薬経鼻投与による神経変性疾患の新規治療戦略
2020 - 2023 プリン体および尿酸の骨髄幹細胞活性に与える影響
2021 - 2022 Neuroprotection of taurine against oxidative stress through miRNA regulation
2019 - 2020 神経保護作用を呈する核酸薬の脳内送達法開発による神経変性疾患治療戦略

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Papers (21)：

Nobuko Matsumura, Chisato Kinoshita, Wattanaporn Bhadhprasit, Toshio Nakaki, Koji Aoyama. A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. Journal of pharmacological sciences. 2023. 151. 1. 37-45
Chisato Kinoshita, Noriko Kubota, Koji Aoyama. Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review. International journal of molecular sciences. 2022. 23. 23. 15076
Chisato Kinoshita, Noriko Kubota, Koji Aoyama. Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2021. 22. 10. 5292
Chisato Kinoshita, Koji Aoyama. The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione. International Journal of Molecular Sciences. 2021. 22. 8. 4245
Chisato Kinoshita, Kazue Kikuchi-Utsumi, Koji Aoyama, Ryo Suzuki, Yayoi Okamoto, Nobuko Matsumura, Daiki Omata, Kazuo Maruyama, Toshio Nakaki. Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression. Communications Biology. 2021. 4. 1. 182

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MISC (20)：

Matsumura Nobuko, Kinoshita Chisato, Nakaki Toshio, Aoyama Koji. The development of miR-96-5p gene knock out technique by CRISPR/Cas9 system. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 3-P1-37
Kinoshita Chisato, Matsumura Nobuko, Aoyama Koji, Nakaki Toshio. Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 1-P1-34
松村暢子, 木下千智, 青山晃治. Mechanism of glutathione production in neurons. 日本薬理学雑誌. 2021. 156. 1. 26-30
Kinoshita Chisato, Kikuchi-Utsumi Kazue, Matsumura Nobuko, Nakaki Toshio, Aoyama Koji. Increased GTRAP3-18 expression by miR-96-5p is mediated by a RNA-binding protein. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 2-P-185
木下千智, 中木敏夫, 青山晃治. 日内リズムを呈するmicroRNAによる神経グルタチオンの制御メカニズム. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd

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Patents (3)：

miR-96-5pインヒビターとそれを含有する医薬組成物
miR-96-5p inhibitor and a screening method for the inhibitor
miR-96-5p阻害剤とそのスクリーニング法

Books (2)：

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 6th Edition
Academic Press 2020
The dopamine receptors
Humana Press 2010 ISBN:9781603273329

Lectures and oral presentations (17)：

The neuroprotective effect of a miR-96-5p inhibitor delivery to brain via the blood-brain barrier
(Neurological Disorders Summit 2023 2023)
Targeted Delivery of MicroRNA-96-5p Inhibitor in the Mouse Brain Using Microbubbles and Ultrasound Technology Enhances Neuroprotection via Increasing Glutathione Levels
(RNA Therapeutics: From Concept to Clinic 2023)
The effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology on neuroprotection and autophagy activation.
(Japan Basic and Clinical Pharmacology Week 2022 2022)
The neuroprotective effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology.
(14th International Conference on Dementia, Alzheimer and Related Diseases 2022)
The effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology on neuroprotection and microglial activation
(The 95th Annual Meeting of the Japanese Pharmacological Society 2022)

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Education (3)：

2004 - 2007 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biomolecular Engineering
2002 - 2004 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biomolecular Engineering
1998 - 2002 Tokyo Institute of Technology School of Bioscience and Biotechnology

Professional career (1)：

博士(工学) (東京工業大学)

Work history (3)：

2023/04 - 現在 Teikyo University School of Medicine Department of Pharmacology associate professor/lecturer
2009/06 - 2023/03 Teikyo University School of Medicine Department of Pharmacology Assistant Professor
2007/04 - 2009/05 University of California, Irvine Postdoctoral Researcher

Association Membership(s) (2)：

THE JAPANESE PHARMACOLOGICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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