Bin Ji

キヒン | Bin Ji

Affiliation and department：
Job title：主任研究員(任常)
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/80392223.ja.html

Research field (2)： Clinical pharmacy , Neurology

Research keywords (21)： PET , ミクログリア , Alzheimer , PBR ligand , TSPO , inflammation , Alzheimer's disease , Gila , Alzheimer病 , PBR , Glia , MCP-1 , アミロイドイメージング , 末梢性ベンゾジアゼピン受容体イメージング , 脳アミロイド , ポジトロン断層撮影 , アミロイドβペプチド , 老人斑 , タウ蛋白 , アルツハイマー病 , 神経原線維変化

Research theme for competitive and other funds (9)：

2021 - 2024 Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseases
2019 - 2021 Targeting CSF1R as imaging biomarker of microglia
2018 - 2021 PET imaging of microglia, a novel drug target for neurodegenerative diseases
2015 - 2018 Development of next-generation PET ligand for neuroinflammation and comparison with current ligands
2015 - 2018 In vivo brain activity imaging in DREADD expressed animals

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Papers (54)：

Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, Junichiro Abe, Chie Seki, Yuji Nagai, Masanori Ichise, et al. Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain. EJNMMI radiopharmacy and chemistry. 2023. 8. 1. 31-31
Hiroki Suzuki, Hiroshi Takeda, Hiroyuki Takuwa, Bin Ji, Makoto Higuchi, Iwao Kanno, Kazuto Masamoto. Capillary responses to functional and pathological activations rely on the capillary states at rest. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023. 43. 6. 1010-1024
Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, et al. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging cell. 2022. e13615
Aya Ogata, Bin Ji, Takashi Yamada, Saori Hattori, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, et al. [11C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors. Bioorganic & medicinal chemistry letters. 2022. 128704-128704
Xiaoyun Zhou, Bin Ji, Chie Seki, Yuji Nagai, Takafumi Minamimoto, Masayuki Fujinaga, Ming-Rong Zhang, Takashi Saito, Takaomi C Saido, Tetsuya Suhara, et al. PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021. 41. 9. 2410-2422

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MISC (25)：

永井裕司, 宮川尚久, Haung Xi-Ping, Slocum Samuel T., Xiong Yan, 堀由紀子, 小山佳, 季斌, 平林敏行, 藤本淳, et al. 化学遺伝学とPETイメージングによるサル脳活動操作とモニタリング. 日本獣医麻酔外科学雑誌. 2019. 50. Suppl.2. 316-316
Nagai Y, Miyakawa N, Takuwa H, Hori H, Oyama K, Ji B, Takahashi M, Haung XP, Slocum ST, Xiong Y, et al. A novel ligand “deschloroclozapine” selectively visualizes and activates chemogenetic receptors in non-human primates. Brain and BrainPET 2019(パシフィコ横浜、横浜市). 2019
武田寛史, 須貸拓馬, 田桑弘之, 季斌, 佐原成彦, 須原哲也, 樋口真人, 冨田裕, 鈴木則宏, 菅野巖, et al. Three-dimensional imaging and quantification of neuro-vascular coupling in the mouse cortex. レーザー学会研究会報告 = Reports the on topical meeting of the Laser Society of Japan. 2017. 17. 25. 21-25
季斌, 樋口真人, 須原哲也. The current status and outlook of radioligand development for neuroinflammation imaging. 老年精神医学雑誌. 2016. 27. 9. 977-983
Makoto Higuchi, Bin Ji, Jun Maeda, Naruhiko Sahara, Tetsuya Suhara. In vivo imaging of neuroinflammation in Alzheimer's disease. Clinical and Experimental Neuroimmunology. 2016. 7. 2. 139-144

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Professional career (1)：

薬学博士 (千葉大学)

Work history (1)：

2010 - 2011 National Institutes for Quantum and Radiological Science and Technology

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