Arai Daisuke

アライダイスケ | Arai Daisuke

Affiliation and department：

Research field (2)： Developmental biology , Molecular biology

Research keywords (4)：ゲノム編集 , 分化・発生 , 幹細胞 , エピジェネティクス

Research theme for competitive and other funds (10)：

2021 - 2024 天然化合物の活性発現分子機構を解析するための統合的プラットフォーム構築
2020 - 2023 In situエピジェネティクス:分化・発生のH3K27me3機能解析の新戦略
2018 - 2022 Elucidation of protein networks controlling proteasomal degradation
2017 - 2020 Nutrition-dependent regulation of Nodal gene by a novel histone O-GlcNAc modification
2017 - 2018 アストロサイト分化を促進する食品成分の探索

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Papers (25)：

Takao Ukaji, Mikako Takahashi-Shibata, Daisuke Arai, Harumi Tsutsumi, Shori Tajima, Wado Akamatsu, Fumihiko Matsumoto, Katsuhisa Ikeda, Shin-ichi Usami, Kazusaku Kamiya. Generation and characterization of a human iPSC line (JUFMDOi007-A) from a patient with Usher syndrome due to mutation in USH2A. Stem Cell Research. 2023. 69. 103100-103100
Satoshi Otsuka, Midori Kawamura, Shutaro Fujino, Fumiaki Nakamura, Daisuke Arai, Nobuhiro Fusetani, Yoichi Nakao. Coronarin D, a Metabolite from the Wild Turmeric, Curcuma aromatica, Promotes the Differentiation of Neural Stem Cells into Astrocytes. Journal of agricultural and food chemistry. 2022. 70. 10. 3300-3309
Daisuke Arai, Yoichi Nakao. Efficient biallelic knock-in in mouse embryonic stem cells by in vivo-linearization of donor and transient inhibition of DNA Polymerase θ/DNA-PK. Scientific Reports. 2021. 11. 18132
Fumiaki Nakamura, Hiroshi Maejima, Midori Kawamura, Daisuke Arai, Tatsufumi Okino, Meng Zhao, Tao Ye, Jungyeol Lee, Young-Tae Chang, Nobuhiro Fusetani, et al. Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii. Bioorganic and Medicinal Chemistry Letters. 2018. 28. 12. 2206-2209
Fumiaki Nakamura, Norio Kudo, Yuki Tomachi, Akiko Nakata, Misao Takemoto, Akihiro Ito, Hodaka Tabei, Daisuke Arai, Nicole de Voogd, Minoru Yoshida, et al. Correction to: Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria. The Journal of antibiotics. 2018. 71. 4. 483-483

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MISC (2)：

廣澤瑞子, 早川晃司, 田中智, 堂前直, 新井大祐, 塩田邦郎. 胎生動物出現の鍵 : 糖による新たなエピジェネティック修飾を発見「哺乳類に特有な病気の原因解明、治療開発に栄養学的観点から期待」. 東京大学大学院農学生命科学研究科プレスリリース. 2016
町田光史, 岡本真由美, 清水功雄, 新井大祐, 伏谷伸宏, 中尾洋一. 新規天然化合物shinanthrene Aとそのエストロゲン活性. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th. 2P-1001 (WEB ONLY)

Patents (7)：

フェルラ酸誘導体含有組成物及びその製造方法
アストロサイト分化促進用組成物
MARINE ORGANISM-DERIVED EXTRACT, COMPOUND, AND MEDICAL COMPOSITION HAVING NICHE FORMATION SUPPRESSING ACTIVITY OF LEUKEMIC STEM CELLS
高血糖によるエピゲノム異常の抑制のための方法及び組成物
アストロサイト分化誘導剤及びGFAP発現誘導剤

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Books (1)：

実験医学 2022年2月号 Vol.40 No.3
羊土社 ISBN:9784758125529

Lectures and oral presentations (10)：

Marine Natural Products that Control a Specific Set of Histone Modifications.
(XVI International Symposium on Marine Natural Products & XI European Conference on Marine Natural Products)
Search and mechanism study of food ingredients affecting histone modifications.
(Health Promotion through Food Science, Chrono-nutrition and Sports Science-From basic to applied research- 2018)
Piceatannol promotes neural stem cell differentiation into astrocytes.
(Food, exercise and technology for health promotion 2018)
Marine natural products that control a specific set of histone modifications.
(The 2015 International Chemical Congress of Pacific Basin Societies)
Marine natural products that control a specific set of histone modifications.
(The 40th Naito Conference)

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Education (3)：

2007 - 2010 Waseda University Graduate School of Advanced Science and Engineering
2005 - 2007 Waseda University Graduate School of Science and Engineering
2001 - 2005 Waseda University School of Education

Professional career (1)：

博士(理学) (早稲田大学)

Work history (7)：

2022/06 - 現在 Juntendo University
2019/04 - 2022/03 早稲田大学先進理工学部化学・生命化学科講師(任期付)
2015/04 - 2019/03 早稲田大学理工学術院総合研究所次席研究員(研究院講師)
2016/10 - 2016/11 The center for Epigenomics, Albert Einstein College of Medicine Visiting Scientist
2013/04 - 2015/03 早稲田大学先進理工学部化学・生命化学科助手

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Association Membership(s) (5)：

日本農芸化学会 , 日本化学会 , 日本ケミカルバイオロジー学会 , 日本エピジェネティクス研究会 , 日本分子生物学会

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