2019 - 2022 Elucidation of structural diversification mechanism of natural product focusing on gene duplication
2019 - 2022 Exploring new biologically active metabolites using unidentified gene clusters from Basidiomycota genomes
2016 - 2021 Refactroing the biosynthesis of polyketide derivatives for synthesizing novel bioactive compounds
2017 - 2020 Predicting the chemical space generated by fungal polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) hybrid
2016 - 2019 Deciphering the structural diversification mechanism by terpene synthase
2015 - 2018 Development of versatile synthesis for fungal natural products by reconstitution of biosynthetic machinery
2015 - 2017 Construction of convergent library for fungal cytochrome P450s and its application to exploring novel functions
2013 - 2015 Development of a rational protocol searching novel biosynthetic gene clusters for natural product synthesis
2014 - 2015 Functional analysis of key enzymes involved in the polyether construction and application for chemo-enzymatic synthesis of polyether natural products
2010 - 2014 Reconstitution of anticancer agent-biosynthetic machinery and elucidation of its mechanism on molecular diversification
2009 - 2010 Biosynthetic study of polyether skeleton : functional analysis of epoxidase and epoxide hydrolase.
Mitsunori Fukaya, Shota Nagamine, Taro Ozaki, Yaping Liu, Miina Ozeki, Taro Matsuyama, Kazunori Miyamoto, Hirokazu Kawagishi, Masanobu Uchiyama, Hideaki Oikawa, et al. Total Biosynthesis of Melleolides from Basidiomycota Fungi: Mechanistic Analysis of the Multi-Functional GMC Oxidase Mld7. Angewandte Chemie (International ed. in English). 2023. e202308881
Yaping Liu, Taro Ozaki, Atsushi Minami, Hideaki Oikawa. Oxidative bicyclic ring system formation involving indole diterpene biosynthesis: Remarkable substrate tolerance of a prenyltransferase and flavoprotein oxidase. Tetrahedron Letters. 2023
Taro Ozaki, Atsushi Minami, Hideaki Oikawa. Recent advances in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides of fungal origin. The Journal of antibiotics. 2022
Shintaro Yamamoto, Taro Matsuyama, Taro Ozaki, Junya Takino, Hajime Sato, Masanobu Uchiyama, Atsushi Minami, Hideaki Oikawa. Elucidation of Late-Stage Biosynthesis of Phomoidride: Proposal of Cyclization Mechanism Affording Characteristic Nine-Membered Ring of Fungal Dimeric Anhydride. Journal of the American Chemical Society. 2022. 144. 46. 20998-21004
深谷充功, 尾関美衣菜, 尾崎太郎, 永木愛一郎, 南篤志, 及川英秋. Total biosynthesis of the basidiomycete derived antitumor substance melleolide (2). 日本化学会春季年会講演予稿集(Web). 2023. 103rd
瀧野純矢, 山本真太郎, 尾崎太郎, 永木愛一郎, 南篤志, 及川英秋. Mechanistic Studies on the Late-Stage Modification Enzymes in the Biosynthesis of Phomoidride B. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
小林瑞季, 尾崎太郎, 橋本勝, 永木愛一郎, 南篤志, 及川英秋. Exploration and functional analysis of sesquiterpene biosynthetic genes based on comprehensive analysis of terpene synthase. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
瀧野純矢, 山本真太郎, 尾崎太郎, 永木愛一郎, 南篤志, 及川英秋, 及川英秋. Total Biosynthesis of Phomoidride B: Identification and Characterization of Methyltransferase Catalyzing Bicyclic Ketal Formation. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
2002 - 2007 Tokyo Institute of Technology Graduate School of Science and Engineering Department of Chemistry
1998 - 2002 Tokyo Institute of Technology School of Science Dept. of Chemistry
Professional career (1)：
博士(理学) (東京工業大学)
Work history (3)：
2015/07 - 現在 Hokkaido University
2008/04 - 2015/06 Hokkaido University
2007/04 - 2008/03 Toyama Prefectural University
Awards (7)：
2023/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Structure and biosynthesis of ribosomal lipopeptide antibiotic albopeptins.
2020/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Biosynthetic study of conidiation-inducing factor conidiogenone: Heterologous production and cyclization mechanism of a key bifunctional diterpene synthase
2017/01 - 北海道大学 平成28年度北海道大学研究総長賞奨励賞
2016/03 - 平成27年度日本化学会進歩賞
2012/09 - 第54回天然有機化合物討論会奨励賞(口頭発表)
2012/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase: Heterologous expression of four biosynthetic genes in Aspergillus oryzae.
2007/07 - 第42回天然物化学談話会奨励賞
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Association Membership(s) (2)：
JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
, THE CHEMICAL SOCIETY OF JAPAN
