Kurashige Takashi

クラシゲタカシ | Kurashige Takashi

Affiliation and department：

Research field (5)： Fetal medicine/Pediatrics , Neurology , Medical biochemistry , Human pathology , Neuroanatomy and physiology

Research keywords (8)：臨床遺伝学 , リピート病 , 運動ニューロン疾患 , 小児神経学 , 神経病理学 , 神経内科学 , 筋疾患学 , 筋病理学

Research theme for competitive and other funds (5)：

2023 - 2028 Necroptosisを介したALSの運動神経変性の病態機序と新規治療の探索
2020 - 2022 筋萎縮性側索硬化症早期診断バイオマーカーとしての生検病理診断法の開発
2019 - 2021 筋萎縮性側索硬化症早期診断のための生検病理診断法の開発
2020 - 抗HMGCR抗体陽性壊死性筋症における LDLコレステロール調節を介した病態の解明
2014 - 2015 MUC1によるオートファジー経路の調節を介したGNE-myopathyの病態解明

Papers (44)：

Hiroyuki Morino, Takashi Kurashige, Yukiko Matsuda, Maiko Ono, Naruhiko Sahara, Tomohiro Miyasaka, Yoshiyuki Soeda, Hitoshi Shimada, Yu Yamazaki, Tetsuya Takahashi, et al. Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation. Movement disorders clinical practice. 2024
Mai Kikumoto, Takashi Kurashige, Tomohiko Ohshita, Kodai Kume, Osamu Kikumoto, Tomohisa Nezu, Shiro Aoki, Kazuhide Ochi, Hiroyuki Morino, Eiichi Nomura, et al. ‘Raisin bread sign’ feature of pontine autosomal dominant microangiopathy and leukoencephalopathy. Brain Communications. 2023
Yoshiko Takebayashi, Yu Yamazaki, Hidetada Yamada, Kyosuke Yazawa, Masahiro Nakamori, Takashi Kurashige, Hiroyuki Morino, Tetsuya Takahashi, Yusuke Sotomaru, Hirofumi Maruyama. Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease. Biochemical and biophysical research communications. 2023. 683. 149106-149106
Kodai Kume, Takashi Kurashige, Keiko Muguruma, Hiroyuki Morino, Yui Tada, Mai Kikumoto, Tatsuo Miyamoto, Silvia Natsuko Akutsu, Yukiko Matsuda, Shinya Matsuura, et al. CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis. American journal of human genetics. 2023. 110. 7. 1086-1097
Wakako Yoshioka, Aritoshi Iida, Kyuto Sonehara, Kazuki Yamamoto, Yasushi Oya, Madoka Mori-Yoshimura, Takashi Kurashige, Mariko Okubo, Megumu Ogawa, Fumihiko Matsuda, et al. Multidimensional analyses of the pathomechanism caused by the non-catalytic GNE variant, c.620A>T, in patients with GNE myopathy. Scientific reports. 2022. 12. 1. 21806-21806

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MISC (58)：

Takashi Kurashige. [Histopathological Diagnostic Marker for ALS: Phosphorylated Transacting Response DNA-Binding Protein of 43kDa in Intramuscular Nerve Bundles]. Brain and nerve = Shinkei kenkyu no shinpo. 2023. 75. 7. 877-887
Shumpei Onishi, Shinji Ohba, Kazuya Kuraoka, Takashi Kurashige, Kazuhiko Sugiyama, Fumiyuki Yamasaki. Molecular and clinical characterization of H3 K27M-mutant “non-midline” glioblastoma: A case report and literature review. Neurocirugia. 2022. 33. 6. 356-360
Haruka Kuroda, Atsushi Yamaguchi, Shuhei Sugata, Takuro Hamada, Riho Moriuchi, Kaoru Wada, Yuzuru Tamaru, Ryusaku Kusunoki, Toshio Kuwai, Hirotaka Kouno, et al. Advanced gallbladder cancer accompanied with cancer-associated dermatomyositis: A case report and literature review. Medicine. 2022. 101. 27. e29477
菊本舞, 菊本舞, 倉重毅志, 大下智彦, 大下智彦, 久米広大, 祢津智久, 青木志郎, 越智一秀, 森野豊之, et al. Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathyの特異的画像所見であるレーズンパン徴候の診断的意義. 日本神経化学会大会抄録集(Web). 2022. 65th
Hiroki Fujii, Takashi Kurashige, Satoshi Kubo, Ran Nakashima, Yasuhito Hamaguchi, Takeshi Kitamura. [Anti-nuclear matrix protein 2 antibody-positive dermatomyositis with the preferential involvement of neck extensors: a case report]. Rinsho shinkeigaku = Clinical neurology. 2021. 61. 11. 743-749

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Lectures and oral presentations (141)：

ALSの早期診断:筋からのアプローチ
(日本神経学会学術大会プログラム・抄録集 2023)
Bright tongue signはALSでの口腔相での嚥下機能低下に先行する
(日本神経学会学術大会プログラム・抄録集 2023)
ALS患者の筋内神経束でのTDP-43凝集
(日本筋学会学術集会プログラム・抄録集 2022)
血管炎の診断における下肢での生検部位に関する検討
(日本筋学会学術集会プログラム・抄録集 2022)
Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathyの特異的画像所見であるレーズンパン徴候の診断的意義
(日本神経化学会大会抄録集(Web) 2022)

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Professional career (1)：

M.D., Ph. D. (Hiroshima University)

Work history (10)：

2024/04 - 現在 Hiroshima University Research Institute for Radiation Biology and Medicine
2023/04 - 現在国立病院機構呉医療センター臨床研究部脳神経病態学研究室長
2023/02 - 現在 Aichi Medical University Institute for Medical Science of Aging
2020/04 - 2024/03 Hiroshima University Research Institute for Radiation Biology and Medicine
2015 - 2023 国立病院機構呉医療センター・中国がんセンター脳神経内科・臨床研究部

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Awards (8)：

2023/09 - The Pan-Asian Consortium for Treatment and Research in ALS (PACTALS) PACTALS2023 Best Oral Presentation - Basic Science (2nd Prize) TDP-43 accumulations appear in intramuscular nerve bundles of ALS patients.
2023/07 - 公益財団法人武田科学振興財団 2023年度医学系研究継続助成(精神・神経・脳領域)
2023/06 - 加藤記念難病研究助成基金研究助成
2023/04 - 冲中記念成人病研究所研究助成
2020/07 - Taiju Life Social Welfare Foundation 2020年度医学研究助成

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Association Membership(s) (10)：

American Academy of Neurology , THE JAPANESE SOCIETY OF CHILD NEUROLOGY , World Muscle Society , JAPAN SOCIETY FOR DEMENTIA RESEARCH , THE JAPAN SOCIETY OF BRAIN TUMOR PATHOLOGY , THE JAPAN SOCIETY OF HUMAN GENETICS , THE JAPANESE SOCIETY OF NEUROPATHOLOGY , JAPANESE SOCIETY OF NEUROLOGY , THE JAPANESE SOCIETY OF PATHOLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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