Ogushi Sugako

オオグシスガコ | Ogushi Sugako

Affiliation and department：
Job title： JSPS Restart Postdoctoral (RPD) Research Fellowships
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/50437505.ja.html

Research field (2)： Applied molecular and cellular biology , Zoological sciences

Research keywords (10)：哺乳類 , 卵母細胞 , 核小体 , 初期胚発生 , 受精卵 , 初期発生 , ヌクレオプラスミン , 全能性 , ヌクレオプラスミン2(Npm2) , 受精

Papers (21)：

Sugako Ogushi, Ahmed Rattani, Jonathan Godwin, Jean Metson, Lothar Schermelleh, Kim Nasmyth. Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8. Developmental cell. 2021. 56. 22. 3100-3114
Sissy E. Wamaitha, Katarzyna J. Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy, Shantha K. Mahadevaiah, Lyn Healy, Rebecca A. Lea, Miriam Molina-Arcas, et al. IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nature Communications. 2020. 11. 1. 764-764
Srinivasan, M., Scheinost, J.C., Petela, N.J., Gligoris, T.G., Wissler, M., Ogushi, S., Collier, J.E., Voulgaris, M., Kurze, A., Chan, K.-L., et al. The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms. Cell. 2018. 173. 6. 1508-1519
Ogushi S, Yamagata K, Obuse C, Furuta K, Wakayama T, Matzuk MM, Saitou M. Reconstitution of the oocyte nucleolus in mice by a single nucleolar protein, NPM2. J Cell Sci. 2017. 130. 14. 2416-2429
Rattani, A., Ballesteros Mejia, R., Roberts, K., Roig, M.B., Godwin, J., Hopkins, M., Eguren, M., Sanchez-Pulido, L., Okaz, E., Ogushi, S., et al. APC/C^Cdh1Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity. Current Biology. 2017. 27. 10. 1462-1476

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MISC (7)：

Ahmed Rattani, Randy Ballestros Mejia, Katherine Roberts, Maurici B. Roig, Jonathan Godwin, Manuel Eguren, Sugako Ogushi, Elwy Okaz, Alberto Pendas, Malumbres Marcos, et al. APC/CCdh1 maintains primordial follicles, germinal vesicle arrest and ensures balanced segregation of chromosomes by enabling removal of Shugoshin-2 from chromosomes arms. MOLECULAR CANCER RESEARCH. 2016. 14
大串素雅子. LEADING EDGE 科学の最前線から「核小体」の通説をくつがえす大発見 : 卵母細胞の核小体は,不要どころか"必需品"だった. Newton. 2013. 33. 5. 110-113
KYOGOKU Hirohisa, OGUSHI Sugako, MIYANO Takashi. Development of Enucleolated Pig Oocytes after Injection of Nucleoli from 2-cell Embryos. 2013. 59. 1. A9
Sugako Ogushi, Takashi Miyano, Mitinori Saitou, Josef Fulka. A unique role of maternal nucleolus in early mammalian development. JOURNAL OF REPRODUCTION AND DEVELOPMENT. 2008. 54. 1. A4-A4
Miyano T, Moniruzzaman M, Ogushi S. Basic physiology of growth and maturation of pig oocytes. Proceedings of the 5th International Symposium “Present and Future of Transgenic Cloned Pig Research”. 2008. pp. 9-14

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Books (2)：

The maternal nucleolus is required for early embryonic development in mammals
Experimental Medicine, YODOSHA 2008 ISBN:9784758100366
Finding of maternal nucleolus as a critical factor for early embryonic development in mammals
Medical Bio, Ohmsha 2008

Lectures and oral presentations (39)：

Cohesin cleavage by SEPARASE is a determinant of different chromosome behavior between bivalents and dyads in mouse meiosis
(London Cell Cycle Club June 2015 2015)
Cohesin cleavage by separase is the determinant of different chromosome behavior between bivalents and dyads in mouse meiosis
(EMBO SMC proteins, Chromosomal organizers from bacteria to human 2015)
Cohesin cleavage by separase is sufficient to induce bivalents to dyads during meiosis I-II transition
(British Meiosis Meeting 2015 2015)
卵母細胞核小体によるヘテロクロマチン確立機構の解明
(科学研究費補助・新学術領域研究(領域提案型)「ゲノムを支える非コード領域の機能」第五回新学術領域会議 2013)
The maternal nucleolus controls the chromatin organization at the zygote's first cell cycle.
(WCU Biomodulation Symposium "From Germplasm to Cloning", 2013)

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Work history (9)：

2023/04 - 現在 Osaka University Graduate School of Medicine JSPS Restart Postdoctoral (RPD) Research Fellowships
2022/11 - 2023/03 Osaka University Graduate School of Medicine Specially Appointed Researcher
2019/07 - 2022/10 The Francis Crick Institute Sex Chromosome Biology Laboratory Senior Laboratory Research Scientist
2019/01 - 2019/05 The Francis Crick Institute Human Embryo and Stem Cell Laboratory Laboratory Research Scientist
2016/04 - 2018/08 University of Oxford Department of Biochemistry Postdoctoral research associate

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