Asumi Yokota

ヨコタアスミ | Asumi Yokota

Affiliation and department：
Job title：助教
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/00571556.ja.html

Research field (2)： Tumor biology , Hematology and oncology

Research keywords (8)： Hematopoiesis , Inflammation , Metabolism , C/EBPβ , 白血病幹細胞 , 慢性骨髄性白血病 , 造血幹細胞 , 転写因子

Research theme for competitive and other funds (7)：

2021 - 2024 形質転換時の代謝リプログラミングにおけるC/EBPβの機能解明と治療戦略の開発
2021 - 2024 慢性炎症下の造血幹細胞制御におけるストレス造血制御因子C/EBPβの機能解明
2021 - 2023 Elucidation of mechanisms involved in differentiation and functions of a novel subset of monocytes
2014 - 2017 Development of a novel therapy against myeloma stem cells in a bone marrow hypoxic niche
2013 - 2016 Maintenance of CML stem cells through regulation of C/EBPbeta transcription factor

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Papers (47)：

Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, et al. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell reports. 2023. 42. 3. 112165-112165
Naoka Kamio, Asumi Yokota, Yuichi Tokuda, Chie Ogasawara, Masakazu Nakano, Miki Nagao, Kei Tashiro, Taira Maekawa, Nobuyuki Onai, Hideyo Hirai. A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties. Journal of immunology (Baltimore, Md. : 1950). 2022. 209. 3. 498-509
Atsushi Sato, Naoka Kamio, Asumi Yokota, Yoshihiro Hayashi, Akihiro Tamura, Yasuo Miura, Taira Maekawa, Hideyo Hirai. C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells. Blood advances. 2020. 4. 14. 3343-3356
平位秀世, 横田明日美, 前川平. CML幹細胞に対するInterferon-αの作用機構. Bio Clinica. 2019. 34. 6. 74-77
Hayashi Y, Yokota A, Harada H, Huang G. Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer. Cancer science. 2019. 110. 5. 1510-1517

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MISC (67)：

Yokota A, Hirai H, Sato A, Kamio N, Hayashi Y, Miura Y, Kimura S, Maekawa T. IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34+ CML Stem Cells. American Society of Hematology, 59th Annual Meeting and Exposition. 2017
Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Kamio N, Torikoshi Y, Miura Y, Maekawa T. mTOR-C/EBPβ-c-Myc Axis Regulates the Behavior of Myeloid-Biased Hematopoietic Stem Cells Under Stress Conditions. American Society of Hematology, 59th Annual Meeting and Exposition. 2017
Functions of the transcription factor C/EBPβ in CML stem cells. 2017. 75. 4. 505-511
平位秀世, 横田明日美, 前川平. 慢性骨髄性白血病の進展におけるC/EBPβの機能解明. 平成29年度金沢大学がん進展制御研究所共同利用・共同研究拠点成果発表会. 2017
Yokota A, Hirai H, Sato A, Kamio N, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Hayashi Y, Kimura S, et al. IFNα upregulates C/EBPβ in CD34+ CML stem cells and induces their exhaustion. 2017

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Work history (3)：

2017/02 - 2020/09 Cincinnati Children's Hospital Medical Center Research Associate
2012/10 - 2017/02 京都大学医学部附属病院輸血細胞治療部研究員
2009/10 - 2012/09 Kyoto Prefectural University of Medicine

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