Rchr
J-GLOBAL ID:201301084534856725
Update date: Apr. 14, 2024
Shimamura Tsuyoshi
シマムラ ツヨシ | Shimamura Tsuyoshi
Affiliation and department:
Homepage URL (1):
http://kaken.nii.ac.jp/d/r/00333617.ja.html
Research field (3):
Digestive surgery
, Other
, General surgery, pediatric surgery
Research keywords (20):
拒絶反応
, Tacrolimus
, Costimulation
, 臓器移植
, 新規免疫抑制剤
, 慢性拒絶反応
, Cyclosporin
, ピリミジン代謝阻害
, NF-κB
, CTLA4Ig
, 肝類洞内皮障害
, CD40Ig
, DHMEQ
, 小腸移植
, タクロリムス
, ホスホジエステラーゼIII阻害剤
, Tolerance
, サイクリックAMP
, edaravone
, 小腸虚血再灌流障害
Research theme for competitive and other funds (20):
- 2023 - 2026 Proton isotope effect as the method to repair marginal liver graft by extracorporeal perfusion
- 2020 - 2023 易傷害性肝グラフトの至適体外灌流法と非侵襲的グラフト機能評価法の開発
- 2019 - 2022 Exploration of the new method to stimulate protective protein function during machine perfusion of steatotic graft
- 2017 - 2021 Renal graft conditioning by simultaneous upregulation of 14-3-3 and Nrf2 during machine perfusion
- 2016 - 2020 Exploration of graft conditioning methods during machine perfusion to augment mitochondrial function and antioxidant ability in steatotic liver graft
- 2014 - 2019 体外誘導免疫制御性リンパ球を用いた細胞治療による免疫寛容誘導に関する研究
- 2015 - 2017 Regulation of chaperone expression outside the body
- 2014 - 2017 Novel methods to regulate hepatic graft by extracorporial perfusion : Chaperoen mediated mechanisms
- 2013 - 2016 Repair method of steatotic grafts aiming to resolve the organ shortage
- 2011 - 2012 Mesothelin and CA 125 expression in digestive carcinoma
- 2010 - 2012 Development of a novel organ preservation solution for the use of liver transplantation
- 2007 - 2008 The novel NF-kB inhibitor, dehydroxymethylepoxyquinomicin, prevents local intestinal ischemia/reperfusion injury in rats
- 2004 - 2006 アデノシン関連物質による臓器虚血再潅流障害の予防
- 2004 - 2006 Development of a gene therapy based new strategy in small bowel transplantation
- 2001 - 2005 Tolerance induction by gene therapy in organ transplantation
- 2003 - 2004 慢性拒絶におけるSDF-1の役割-In vitroでの機能解析と中和抗体を用いた治療実験-
- 2003 - 2004 Development of a new immunosuppressive strategy by targeting pyrimidine synthesis
- 2001 - 2003 Development of safety methods for adult to adult living donor liver transplantation focused on cyclic AMP signal pathway.
- 2001 - 2003 Development of new preservation solution to maintain vascular endothelial Integlity.
- 2000 - 2002 心停止ドナーからの肝臓移植法の開発
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Papers (248):
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Takuji Ota, Ryoichi Goto, Takuya Harada, Agustina Forgioni, Ryo Kanazawa, Yoshikazu Ganchiku, Norio Kawamura, Masaaki Watanabe, Moto Fukai, Tsuyoshi Shimamura, et al. TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non-Fc Receptor-Binding CD3 Antibodies. ImmunoHorizons. 2024. 8. 4. 295-306
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Moto Fukai, Sodai Sakamoto, Kengo Shibata, Takahisa Ishikawa, Norio Kawamura, Masato Fujiyoshi, Sunao Fujiyoshi, Kosei Nakamura, Hiroki Bochimoto, Shingo Shimada, et al. Important Constituents of Heavy Water-containing Solution for Cold Storage and Subsequent Reperfusion on an Isolated Perfused Rat Liver. Transplantation proceedings. 2024
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Sodai Sakamoto, Hiroki Bochimoto, Kengo Shibata, Nur Khatijah Mohd Zin, Moto Fukai, Kosei Nakamura, Takahisa Ishikawa, Masato Fujiyoshi, Tsuyoshi Shimamura, Akinobu Taketomi. Exploration of Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved after Circulatory Death. Journal of clinical medicine. 2023. 12. 11
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Moto Fukai, Sodai Sakamoto, Kengo Shibata, Masato Fujiyoshi, Sunao Fujiyoshi, Hiroki Bochimoto, Takahisa Ishikawa, Shingo Shimada, Kosei Nakamura, Norio Kawamura, et al. Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers. Transplantation proceedings. 2023. 55. 4. 1027-1031
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太田 拓児, 後藤 了一, 原田 拓弥, 川村 典生, 渡辺 正明, 嶋村 剛, 武冨 紹信. 当施設における肝移植後de novo腫瘍の検討. 日本外科系連合学会誌. 2023. 48. 3. 424-424
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MISC (620):
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深井原, 柴田賢吾, 藤好直, 川村典生, 本井慧路, 藤好真人, 石川隆壽, 中村恒星, 暮地本宙己, 嶋村剛, et al. The optimal pH during machine perfusion varies depending on the temperature. Organ Biology (Web). 2023. 30. 3
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深井原, 中薮拓哉, 大谷晋太郎, 柴田賢吾, 坂本聡大, 石川隆壽, 島田慎吾, 若山顕治, 藤好真人, 川村典生, et al. 新規抗酸化物質3,5-dihydroxy-4-methoxybenzyl alcohol(DHMBA)は小腸上皮細胞の冷保存傷害を軽減する. 日本外科学会定期学術集会(Web). 2021. 121st
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小林 展大, 後藤 了一, 矢部 沙織, 加藤 拓也, 川村 典生, 腰塚 靖之, 三野 和宏, 渡辺 正明, 植村 一仁, 高橋 宏明, et al. 生体肝移植後に発症したde novo膵癌の2例. 移植. 2019. 53. 6. 365-371
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高橋 直規, 後藤 了一, 渡辺 正明, 川村 典生, 財津 雅昭, 神山 俊哉, 嶋村 剛, 武冨 紹信. 南回りB2/3胆管を伴う肝左葉グラフトを用いた生体肝移植の一例. 日本臨床外科学会雑誌. 2019. 80. 2. 439-439
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入村泉, 中島一朗, 渕之上昌平, 丸橋繁, 鳴海俊治, 中村雅史, 大段秀樹, 鈴木康之, 若井俊文, 丸山通広, et al. 膵移植後の1型糖尿病患者における膵島関連自己抗体陽性率~多施設共同研究 第2報~. 日本膵・膵島移植研究会プログラム・抄録集. 2019. 46th
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Professional career (1):
Work history (1):
- 2011 - Hokkaido University
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