Rchr
J-GLOBAL ID：201301085863381254   Update date: Mar. 23, 2024

Handa Hiroshi

ハンダ ヒロシ | Handa Hiroshi
Affiliation and department：
Tokyo Medical University Graduate School of Bioscience and Biotechnology

About Tokyo Medical University Graduate School of Bioscience and Biotechnology


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/80107432.ja.html
Research field  (9)： Molecular biology ,  Pharmaceuticals - chemistry and drug development ,  Virology ,  Pharmaceuticals - chemistry and drug development ,  Chemical biology ,  Polymer materials ,  Functional biochemistry ,  Pharmacology ,  Molecular biochemistry
Research keywords  (28)： Transcription elongation reaction ,  Rate-limiting step ,  Tanscriptional regulator of elongation ,  Negative elongation factor (NELF) ,  DRB sensitivity inducing factor (DSIF) ,  Promoter-proximal pausing ,  Transcription elongation inhibitor ,  5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) ,  Mechanism of DRB action ,  Affinity nanomagnetic beads ,  Chemical biology ,  Drug target ,  Thalidomide ,  Cereblon (CRBN) ,  Teratogenicity ,  Anticancer effect ,  E3 Ubiquitin ligase ,  Substrate receptor ,  Targeted proteolysis ,  Mechanism of thalidomide action ,  Substrate protein ,  Thalidomide derivatives ,  Molecular glue ,  PROTAC ,  SV40 ,  Virus-like particle (VLP) ,  Capsid protein ,  Vaccine
Research theme for competitive and other funds  (74)：
  • 2017 - 2020 Search for novel modulators of cereblon, the target of thalidomide that regulates neural stem cell proliferation and deifferentiation
  • 2016 - 2020 Elucidation of the mechanism of action of novel antiepileptic drugs using functionalized magnetic nanoparticles and exploration of their neuroprotective effects
  • 2015 - 2019 Elucidation of the new target proteins of acetaminophen using high-performance magnetic nano beads
  • 2014 - 2017 ER-stress loading therapy in refractory multiple myeloma
  • 2011 - 2016 Chemical biology using natural products
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Papers (317)：
  • Yu Wang, Shunsuke Shimosaki, Emi Ikebe, Hidekatsu Iha, Jun-ichi Yamamoto, Nichole Fife, Tomonaga Ichikawa, Mitsuo Hori, Masao Ogata, Yoshiyuki Tsukamoto, et al. IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors. Frontiers in Oncology. 2024. 13
  • Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, et al. Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drugs-induced thromboembolism. Blood advances. 2024
  • Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami. In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein. Methods in molecular biology (Clifton, N.J.). 2024. 2707. 257-264
  • Takumi Ito, Tomoko Asatsuma-Okumura, Akinori Endo, Junichi Yamamoto, Yoshiko Iwai, Yuki Yamaguchi, Mikihiko Naito, Hiroshi Handa, Yasushi Saeki. ZNF276 and WIZ are CRBN neosubstrates involved in the anti-angiogenic activity of thalidomide and immunomodulatory drugs. 2023
  • Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami. Dysregulated TDP-43 proteostasis perturbs excitability of spinal motor neurons during brainstem-mediated fictive locomotion in zebrafish. Development, growth & differentiation. 2023
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MISC (280)：
  • 朝妻知子, 半田宏, 伊藤拓水. Development of new cereblon modulators and their target proteins. 月刊血液内科. 2022. 84. 4
  • Takumi Ito, Yuki Yamaguchi, Hiroshi Handa. Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology. Cell Chemical Biology. 2021. 28. 7. 987-999
  • Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami. Illuminating ALS Motor Neurons With Optogenetics in Zebrafish. Frontiers in Cell and Developmental Biology. 2021. 9
  • Tomomi Sato, Takumi Ito, Hiroshi Handa. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Frontiers in Cell and Developmental Biology. 2021. 9
  • 伊藤拓水, 朝妻知子, 半田宏. Targeted Protein Degradation: Molecular Glue Degrader. 月刊細胞. 2021. 53. 3
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Books (65)：
  • サリドマイド胎芽症診療ガイド2020
    国立国際医療研究センター病院 2020
  • Guide for the management of thalidomide embryopathy 2020
    The research group on grasping the health and living situation as well as creating the support infrastructure for thalidomide-impaired people in Japan 2020
  • Magnetic nanoparticles for medical diagnostics
    IOP Publishing (IPEM-IOP Series in Physics and Engineering in Medicine and Biology) 2018 ISBN:9780750315821
  • Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology
    William Andrew 2017
  • Nanoscale fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology
    Elsevier Science Ltd., Amsterdam 2017
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Lectures and oral presentations  (212)：
  • Identification of the thalidomide target CRBN to the development of targeted protein degraders
    (The 25th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy (JFCR-ISCC) 2022)
  • Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of targeted protein degraders
    (The International Symposium in Tokyo 2022 Ubiquitin New Frontier from Neo- Biology to Targeted Protein Degradation 2022)
  • サリドマイドのターゲットCereblonの発見と展開:先天異常発症機序の解明から創薬へ
    (第61回日本先天異常学会学術集会 特別講演 2021)
  • セレブロン
    (造血Happy Hour 医科学研究所 血液研究グループ 2021)
  • ポマリドミド依存的なCRLCRBNのネオ基質 ー最近同定された二つの新規ネオ基質ー
    (Multiple Myeloma Web Seminar BMS/Celgene 2021)
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Education (2)：
  • 1972 - 1976 Keio University Graduate School of Medicine, Doctoral Program
  • 1966 - 1972 Keio University School of Medicine
Professional career (1)：
  • 医学博士 (慶應義塾大学)
Work history (10)：
  • 2013 - 現在 Tokyo Medical University Department of Chemical Biology Professor
  • 2012 - 現在 Tokyo Institute of Technology Professor Emeritus
  • 2012 - 2013 Tokyo Institute of Technology Professor
  • 1991 - 2012 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Professor
  • 1987 - 1991 The University of Tokyo School of Medicine Associate Professor
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Committee career (21)：
  • 2009 - 現在 独立行政法人 工業所有権情報・研修館(INPIT) 知的財産プロデューサー等派遣事業推進委員会委員(副委員長)、他
  • 1999 - 2011 国立研究開発法人 新エネルギー・産業技術総合開発機構(NEDO) 産業技術研究開発委員会委員、他各種 委員会委員・審査委員・評価委員・専門委員
  • 2011 - 実験動物中央研究所 アドバイザリーコミッティー委員
  • 2010 - Frontiers in Analytical and Experimetnal Pharmacology Editorial Board
  • 2010 - 株式会社 JVC-ケンウッド 技術コンサルタント
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Awards (12)：
  • 2017 - 島津賞 新しいナノ磁性ビーズによる創薬標的の 単離・同定・計測技術の開発
  • 2011 - 手島記念研究賞 研究論文賞
  • 2010 - 日刊工業新聞第5回モノづくり連携大賞 特別賞 薬剤標的タンパク質を効率的に精製・単離できる新規アフィニティ磁性ビーズの創製と薬剤標的タンパク質スクリーニングシステムの事業化
  • 2005 - 文部科学大臣表彰 科学技術賞(研究部門)
  • 2002 - 手島記念研究賞 発明賞 SG粒子を用いたスクリーニング方法
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Association Membership(s) (4)：
American Society for Microbiology ,  日本ケミカルバイオロジー学会 ,  日本分子生物学会 ,  日本生化学会
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