Rchr
J-GLOBAL ID:201301087783241314   Update date: Jan. 30, 2024

Ishikawa Tokiro

イシカワ トキロウ | Ishikawa Tokiro
Affiliation and department:
Research field  (1): Molecular biology
Research theme for competitive and other funds  (6):
  • 2022 - 2025 近接依存性ビオチン標識法による組織特異的小胞体ストレス原因タンパク質の探索
  • 2019 - 2022 Establishment of medaka lifespan measurement system
  • 2017 - 2019 Analysis of the mechanism under the occurrence of bicephaly during development in medaka fish with a defective UPR pathway
  • 2015 - 2017 Screening of transport component of ATF6 by haploid medaka system
  • 2014 - 2017 Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates
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Papers (18):
  • Tomoyo Ikeda, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Masaya Ono, Kazutoshi Mori. Proteomic analysis of fatty liver induced by starvation of medaka fish larvae. Cell structure and function. 2023. 48. 2. 123-133
  • Byungseok Jin, Tokiro Ishikawa, Makoto Kashima, Rei Komura, Hiromi Hirata, Tetsuya Okada, Kazutoshi Mori. Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish. Life Science Alliance. 2023. 6. 7. e202201771-e202201771
  • Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori. Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice. Molecular Biology of the Cell. 2023
  • Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori. Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice. Molecular biology of the cell. 2023. mbcE22070292
  • Shunsuke Saito, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Kazutoshi Mori. A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b. eLife. 2022. 11
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MISC (21):
  • 蜷川暁, 多田誠一郎, 奥村正樹, 井ノ口健太, 木下岬, 金村進吾, 金村進吾, 今見考志, 梅澤元, 石川時郎, et al. The second-generation antipsychotic olanzapine induces aberrant intermolecular disulfide bonds of proinsulin. 日本細胞生物学会大会(Web). 2021. 73rd
  • 蜷川暁, 多田誠一郎, 奥村正樹, 井ノ口健太, 木下岬, 金村進吾, 今見考志, 梅澤元, 石川時郎, MACKIN Robert, et al. The second generation antipsychotic olanzapine induces atypical development of diabetes due to aberrant disulfide bond formations of proinsulin in pancreatic beta cells. 日本薬学会年会要旨集(Web). 2021. 141st
  • 松下和智, 蜷川暁, 杉本岳大, 岡田徹也, 石川時郎, 佐久間哲史, 山本卓, 森和俊. The regulation by OS9 and XTP3B in ER-associated degradation depends on the degree of structural abnormality of degradation substrates. 日本糖質学会年会要旨集. 2021. 40th
  • 蜷川暁, GEORGE Ginto, 矢木宏和, 古川潤一, 橋井則貴, 石井明子, DENG Ying, 石川時郎, 今見考志, 石濱泰, et al. A mannosidase in the endoplasmic reticulum exerts its function by protein-protein association. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
  • 蜷川暁, GEORGE Ginto, 矢木宏和, 住友嘉樹, 真木勇太, 石川時郎, 佐久間哲史, 山本卓, 今見考志, 石濱泰, et al. Elucidation of molecular mechanisms and functions of N-glycan mannose trimming required for glycoprotein ER-associated degradation pathway. 日本糖質学会年会要旨集. 2021. 40th
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Professional career (1):
  • 博士(理学) (京都大学)
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