IKUO Mariko

Affiliation and department：
Job title：助教

Research field (1)： Molecular biology

Research keywords (12)：エクソソーム , exosome , miRNA , microRNA , Senescence , exosome , cancer , non-coding RNA , neuron , carbohydrate chane , Lysosome Storage Disease , Comprehensive Brain Science Network

Research theme for competitive and other funds (8)：

2018 - 2022 多発性骨髄腫が分泌するエクソソームによる骨分化抑制機構の解明
2017 - 2018 .
2018 - 2018 .
2014 - 2017 Comprehensive analysis of the pathogenic mechanism of GM2 gangliosidoses involving neurological symptoms by focusing on transcriptomes including ncRNA
2014 - 2016 Establishment of induced neurons (iN cells) derived from lysosomal disease patients involving neurological symptoms and elucidation of regulatory mechanism of neurodegeneration

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Papers (12)：

Hirokazu Miki, Shingen Nakamura, Asuka Oda, Hirofumi Tenshin, Jumpei Teramachi, Masahiro Hiasa, Ariunzaya Bat-Erdene, Yusaku Maeda, Masahiro Oura, Mamiko Takahashi, et al. Effective impairment of myeloma cells and their progenitors by hyperthermia. Oncotarget. 2018. 9. 12. 10307-10316
Hui Ling, Karen Pickard, Cristina Ivan, Claudio Isella, Mariko Ikuo, Richard Mitter, Riccardo Spizzo, Marc D. Bullock, Cornelia Braicu, Valentina Pileczki, et al. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis. GUT. 2016. 65. 6. 977-989
Keisuke Kitakaze, Chikako Tasaki, Yasumichi Mizutani, Eiji Sugiyama, Mariko Ikuo, Mako Kamiya, Mitsutoshi Setou, Yasuteru Urano, Kohji Itoh. Development of protease-resistant modified human beta-hexosaminidase B and evaluation of intracerebroventricular replacement effects on GM2 gangliosidosis model mice. MOLECULAR GENETICS AND METABOLISM. 2015. 114. 2. S65-S65
Hui Ling, George Calin, Milena Nicoloso, Mariko Ikuo. Biological and clinical significance of miR-224 in colorectal cancer. CANCER RESEARCH. 2014. 74. 19
Mariko Ikuo, Gentaro Nagano, Yuki Saito, Han Mao, Kazuhisa Sekimizu, Chikara Kaito. Inhibition of Exotoxin Production by Mobile Genetic Element SCCmec-Encoded psm-mec RNA Is Conserved in Staphylococcal Species. PLOS ONE. 2014. 9. 6. e100260

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MISC (5)：

Books (1)：

DNA and Histone Modifications in Cancer Diagnosis, In book: DNA and Histone Methylation as Cancer Targets
Springer 2017

Lectures and oral presentations (23)：

BMP2-dependent osteoblast differentiation is suppressed by multiple myeloma-derived extracellular vesicles
(ISEV2019 2019)
骨芽前駆細胞の骨分化経路BMP/Smadは、核内DNA結合Smadを標的とする多発性骨髄腫由来分泌小胞exosomeによって抑制される
(第91回日本生化学会大会 2018)
Extracellular vesicles derived from senescent cells repress tumor growth via miRNAs
(ISEV2018 2018)
Senescent cell-derived extracellular vesicles inhibits tumor activities via miRNAs
(MIRAI seminar 2017 2017)
Senescent cell-derived extracellular vesicles inhibits tumor activities via miRNAs
(MIRAI seminar 2017 2017)

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Professional career (1)：

博士(薬学) (東京大学)

Committee career (1)：

2018 - 2019 International Society for Extracellular Vesicles ISEV2019 International Organizing Committee

Awards (1)：

2016/09 - The 8th JARI Annual Meeting/The 3rd JSDV Annual Meeting Award prize for Young Scientist

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