Mii Yusuke

ミイユウスケ | Mii Yusuke

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/70634129.ja.html

Research field (2)： Cell biology , Developmental biology

Research keywords (9)： planar cell polarity (PCP) , モルフォゲン , sFRP , Wnt , アフリカツメガエル , 拡散 , ヘパラン硫酸 , 転写因子 , 分泌性蛋白質

Research theme for competitive and other funds (15)：

2023 - 2028 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
2023 - 2028 ECMと分泌性シグナルの動的カップリング機構
2022 - 2027 Planar cell polarity as self-organization involving localized Wnt protein
2022 - 2025 An in vitro system of coordinated planar cell polarity.
2019 - 2023 Wntによる平面細胞極性の動的形成機構の解明

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Papers (19)：

Thi Hong Nguyen Tran, Ritsuko Takada, Elena Krayukhina, Takahiro Maruno, Yusuke Mii, Susumu Uchiyama, Shinji Takada. Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion. Communications Biology. 2024. 7. 1
Yusuke Mii. Understanding and manipulating extracellular behaviors of Wnt ligands. In Vitro Cellular & Developmental Biology - Animal. 2024
Minako Suzuki, Shinji Takada, Yusuke Mii. Dissection of N-deacetylase and N-sulfotransferase activities of NDST1 and their effects on Wnt8 distribution and signaling in Xenopus embryos. Development, Growth & Differentiation. 2024
Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, et al. The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells. Science signaling. 2023. 16. 794. eabp9020
Yudai Hatakeyama, Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto, Honda Naoki, Shinji Takada. Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nature Communications. 2023. 14. 1

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MISC (2)：

Yusuke Mii. Heparan Sulfate Clusters Regulate Distribution and Signaling of Wnt Morphogens. Trends in Glycoscience and Glycotechnology. 2020. 32. 190. J181-J187
Yoshihiro Tsuchiya, Tadashi Okubo, Yusuke Mii, Shinji Takada. Adapter protein Ripply3 is required for epithelial morphogenesis in the mouse pharyngeal pouch. MECHANISMS OF DEVELOPMENT. 2017. 145. S154-S154

Lectures and oral presentations (18)：

Symmetry breaking of planar cell polarity by Wnt.
(International Workshop on Multi-scale Biological Plasticity (Komaba, Tokyo) 2024)
Multiple positive feedback loops are involved in the symmetry breaking of planar cell polarity (PCP) by Wnt.
(2023)
一本鎖抗体(scFv)の応用で見えてきた平面細胞極性におけるダイナミックなヘパラン硫酸プロテオグリカンの挙動
(日本動物学会第94回山形大会 2023)
Mutual regulation among Wnt11 and core PCP components is involved in self-organization of planar cell polarity.
(Wnt Signaling, Gordon Research Conference 2023)
Self-organization of planar cell polarity by mutual regulation among Wnt11 and core PCP components.
(2023)

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Education (3)：

2009 - 2012 University of Tokyo Graduate School of Science Department of Biological Sciences Ph.D.
2007 - 2009 University of Tokyo Graduate School of Science Department of Biological Sciences M.Sc
2005 - 2007 University of Tokyo Faculty of Science Department of Biological Sciences, B.Sc

Professional career (1)：

Work history (4)：

2024/04 - 現在 Institute for Life and Medical Sciences, Kyoto University Assistant Professor
2012/04 - 2024/03 National Institute for Basic Biology
2019/10 - 2023/03 Japan Science and Technology Agency
2009/04 - 2012/03 JSPS Research Fellow (DC1)

Awards (7)：

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Association Membership(s) (1)：

JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS

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