Sasanuma Hiroyuki

Affiliation and department：

Research field (3)： Molecular biology , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (6)： Genome editing , Steroid hormone , Breast cancer , Topoisomerase2 , Chemical Genetics , DNA double-strand break repair

Research theme for competitive and other funds (11)：

2019 - 2022 Establishment of novel mouse early breast cancer induction model for studies of breast tumorigenesis and prevention
2019 - 2022 Elucidation of the ubiquitin pathway that removes adducts attached to DNA double-strand breaks
2016 - 2021 Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
2018 - 2020 Investigation of Molecular Mechanisms Underlying Oncogenesis in HBOC Syndrome
2016 - 2019 Elucidation of pathological mechanism caused by defects in the repair of TOPII-induced DNA double-strand breaks

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Papers (66)：

正井久雄, 田中卓, 井口智弘, 伊藤さゆり, 覺正直子, 深津理乃, 加納豊, 鷺朋子, 笹沼博之. 染色体DNA複製開始複合体と開始制御メカニズムの新たな展望 DNA複製制御における特異なDNA構造の役割(Roles of unusual DNA structures in regulation of DNA replication). 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2S14m-04]
Akiko Tomita, Hiroyuki Sasanuma, Tomoo Owa, Yuka Nakazawa, Mayuko Shimada, Takahiro Fukuoka, Tomoo Ogi, Shinichiro Nakada. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. Nature communications. 2023. 14. 1. 5607-5607
Maki Sakurada-Aono, Takashi Sakamoto, Masayuki Kobayashi, Yoko Takiuchi, Fumie Iwai, Kohei Tada, Hiroyuki Sasanuma, Shigeki Hirabayashi, Yasuhiro Murakawa, Kotaro Shirakawa, et al. HTLV-1 bZIP factor impairs DNA mismatch repair system. Biochemical and biophysical research communications. 2023. 657. 43-49
Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi, et al. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen. Cell Reports. 2023. 42. 1. 111909-111909
Salma Akter, Akihiro Shimba, Koichi Ikuta, Rasel Al Mahmud, Shintaro Yamada, Hiroyuki Sasanuma, Masataka Tsuda, Masakatsu Sone, Yukio Ago, Kenichi Murai, et al. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks. Genes to Cells. 2022

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MISC (29)：

IGUCHI Tomohiro, YAMAZAKI Satoshi, ONO Tomio, ISHII Rie, HORI Karin, KOBAYASHI Shunsuke, SASANUMA Hiroyuki, MASAI Hisao. Neural stem cell- or Hematopoietic stem cell-specific knockout of Cdc7 or ASK(Dbf4) exhibits common and distinct phenotypes. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
正井久雄, 井口智弘, 伊藤さゆり, 加納豊, 覺正直子, 深津理乃, 森山賢治, 笹沼博之. 核酸-タンパク質-リン脂質相互作用を介した染色体高次構造の形成制御. 日本生化学会大会(Web). 2022. 95th
IGUCHI Tomohiro, ITO Sayuri, KAKUSHO Naoko, YAMAZAKI Satoshi, OJI Asami, FUKATSU Rino, HIRATANI Ichiro, SASANUMA Hiroyuki, MASAI Hisao. Association of Rif1 with nuclear membrane is essential for genome-wide replication timing regulation. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
正井久雄, 井口智弘, 伊藤さゆり, 森山賢治, 覺正直子, 加納豊, 高沢佳芳, 田中卓, 鷺朋子, 深津理乃, et al. Chromatin regulation that involves assembly of protein, lipid and DNA with a special higher-order structure. 日本生化学会大会(Web). 2021. 94th
竹石歩奈, 古樫浩之, 小田切瑞基, 笹沼博之, 武田俊一, 安井学, 本間正充, 菅澤薫, 浦聖恵, 佐々彰. Tyrosyl-DNA phosphodiesterasesはDNA中のリボヌクレオチドを起因とする突然変異形成に関与する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd

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Education (3)：

2003 - 2007 Saitama University
1999 - 2001 Osaka university Graduate school of science
- 1999 Osaka university Faculty of Science

Professional career (1)：

博士(理学)

Work history (6)：

2021/04 - 現在 Tokyo Metropolitan Institute of Medical Science
2013/01 - 2021/03 Kyoto university Graduate School of Medicine Associate professor
2011/04 - 2012/12 Kyoto university Graduate School of Medicine Assistant professor
2008/03 - 2011/03 Institute of Protein Research, Osaka university Postdoctoral fellow
2007/05 - 2008/02 University of Tokyo Graduate School of Arts and Sciences, College of Arts and Sciences Postdoctoral fellow

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Association Membership(s) (5)：

The Japanese Society of Genome Editing , 分子生物学会 , THE GENETICS SOCIETY OF JAPAN , The Japanese Radiation Research Society , Japan Cancer Association

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