Research theme for competitive and other funds (8)：
2022 - 2025 Analysis of pathological dynamics of membrane-less organelles in SALS
2021 - 2024 扁桃体腫大を伴う側頭葉てんかんの病態背景の解明と新規治療法の開発
2019 - 2022 DEAD box RNA helicases are involved in sporadic ALS pathology
2017 - 2020 Study of pathogenesis caused by hypouricemia in multiple system atrophy
2017 - 2019 Elucidation of abnormal accumulation of DDX17 in motor neuron of ALS
2015 - 2017 Analysis of polyglutamine aggregation protein in ALS/FTLD
2014 - 2017 Calcium-signaling abnormality of polyglutamine diseases
2014 - 2016 Analysis of RNA binding proteins in polyglutamine disease
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Papers (59)：
Takuya Ikeda, Keita Takahashi, Minatsu Higashi, Hiroyasu Komiya, Tetsuya Asano, Akihiro Ogasawara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Kenichi Tanaka, et al. Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model mice. Cell death discovery. 2023. 9. 1. 454-454
Taishi Wada, Hiroshi Doi, Masaki Okubo, Mikiko Tada, Naohisa Ueda, Hidefumi Suzuki, Wakana Tominaga, Haruki Koike, Hiroyasu Komiya, Shun Kubota, et al. RNA foci in two bi-allelic RFC1 expansion carriers. Annals of neurology. 2023
Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, et al. Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis. Frontiers in Neurology. 2022. 13
Shinichi Kameyama, Takeshi Mizuguchi, Hiroshi Doi, Shigeru Koyano, Masaki Okubo, Mikiko Tada, Hiroshi Shimizu, Hiromi Fukuda, Naomi Tsuchida, Yuri Uchiyama, et al. Patients with biallelic GGC repeat expansions in NOTCH2NLC exhibiting a typical neuronal intranuclear inclusion disease phenotype. Genomics. 2022. 114. 5. 110469-110469
