Rchr
J-GLOBAL ID：201401004092853091   Update date: Mar. 14, 2024

Morimura Toshifumi

モリムラ トシフミ | Morimura Toshifumi
Affiliation and department：
滋賀医科大学・神経難病研究センター 神経診断治療学部門・橋渡し研究ユニット

About 滋賀医科大学・神経難病研究センター 神経診断治療学部門・橋渡し研究ユニット


Job title： 学内講師
Research field  (5)： Laboratory animal science ,  Neuroscience - general ,  Developmental biology ,  Molecular biology ,  Neuroanatomy and physiology
Research theme for competitive and other funds  (10)：
  • 2022 - 2026 新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発
  • 2022 - 2025 PKD遺伝子異常に伴う脳動脈瘤発生の病態解明
  • 2020 - 2023 Drug discovery against ER stress by using a novel luminescence probe sensing ER environments
  • 2017 - 2020 Pathological and therapeutic research of sporadic ALS
  • 2014 - 2018 Development of a novel molecular targeting therapy and probe, using antibodies against pathogenic epitopes in TDP-43
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Papers (67)：
  • 柳沢 大治郎, 守村 敏史, 西村 正樹, 遠山 育夫, 依馬 正次, 石垣 診祐. APPトランスジェニックカニクイザルの開発 脳脊髄液バイオマーカー. Dementia Japan. 2023. 37. 4. 711-711
  • Hideki Wada, Ryota Hikiami, Makiko Kusui, Sumio Minamiyama, Megumi Asada-Utsugi, Akemi Shodai, Shin-Ichi Muramatsu, Toshifumi Morimura, Makoto Urushitani. In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD. Neuroscience research. 2023
  • Ryota Hikiami, Toshifumi Morimura, Takashi Ayaki, Tomoyuki Tsukiyama, Naoko Morimura, Makiko Kusui, Hideki Wada, Sumio Minamiyama, Akemi Shodai, Megumi Asada-Utsugi, et al. Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates. Scientific reports. 2022. 12. 1. 16030-16030
  • Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, et al. Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro. Communications biology. 2022. 5. 1. 358-358
  • Buyandelger Undral, ウォカー・ダグラス, 柳沢 大治郎, 守村 敏史, 遠山 育夫. 神経炎と血管新生におけるミトコンドリア性フェリチン(FtMt)の役割(Roles of mitochondrial ferritin(FtMt) in neuroinflammation and angiogenesis). Dementia Japan. 2020. 34. 4. 527-527
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MISC (9)：
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Books (2)：
  • Molecular Targeted Therapy against Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.
    Nova Science Publishers, Inc 2013
  • Molecular Targeted Therapy against Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.
    Nova Science Publishers, Inc 2013
Education (4)：
  • - 1997 Hokkaido University
  • - 1997 Hokkaido University Graduate School, Division of Veterinary Medicine
  • - 1993 Hokkaido University School of Veterinary Medicine
  • - 1993 Hokkaido University Faculty of Veterinary Medicine
Professional career (1)：
  • 博士(獣医学) (北海道大学)
Work history (9)：
  • 2020/08 - 現在 Shiga University of Medical Science Research Center for Animal Life Science Associate Professor
  • 2020/04 - 2020/07 Shiga University of Medical Science Molecular Neuroscience Research Center
  • 2013/04 - 2020/03 Shiga University of Medical Science Molecular Neuroscience Research Center Assistant Professor
  • 2012/04 - 2013/03 Shiga University of Medical Science Molecular Neuroscience Research Center Project Assistant Professor
  • 2009 - 2012 国立精神・神経医療研究センター 流動研究員
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Association Membership(s) (3)：
Japanese Association for Laboratory Animal Science ,  Japanese Society of Veterinary Science ,  The Japan Neuroscinece Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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