Rchr
J-GLOBAL ID:201401007076551297   Update date: Feb. 01, 2024

Takumi Ueda

ウエダ タクミ | Takumi Ueda
Affiliation and department:
Homepage URL  (1): http://kaken.nii.ac.jp/d/r/20451859.ja.html
Research field  (1): Pharmaceuticals - analytical and physicochemistry
Research keywords  (28): NMR ,  膜タンパク質 ,  転移交差飽和法 ,  タンパク質-タンパク質相互作用 ,  構造生物学 ,  光合成明反応 ,  photosynthesis ,  CCR1 ,  オピオイド受容体 ,  生化学 ,  アドレナリン受容体 ,  交差飽和法 ,  電子移動反応 ,  フェレドキシン ,  Membrane protein ,  ケモカイン受容体 ,  protein-protein interaction ,  electron transfer ,  過渡的相互作用 ,  マルチドメイン蛋白質 ,  膜蛋白質 ,  GPCR ,  Segmental labeling ,  核磁気共鳴法 ,  transferred cross saturation ,  循環的電子伝達 ,  光化学系I ,  Protein Trans-Splicing
Research theme for competitive and other funds  (15):
  • 2021 - 2023 薬物とGPCRの弱い相互作用が滞在時間に応じて生体応答を制御する機構の解明
  • 2020 - 2023 核磁気共鳴法によるG蛋白質共役型受容体の活性制御機構の解明
  • 2017 - 2022 in situ functional analyses of membrane proteins by NMR
  • 2019 - 2021 動的構造平衡情報に基づく数理解析によるGPCRのシグナル制御機構の解明
  • 2018 - 2020 核磁気共鳴法による分子夾雑系膜環境におけるG蛋白質共役型受容体の機能解明
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Papers (46):
  • Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E Townsend, Colin N Kelly, Matthew R Naylor, Hsiau-Wei Lee, Kayoko Kanamitsu, Mayumi Ishii, Ryosuke Ueki, et al. Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides. Nature communications. 2023. 14. 1. 1416-1416
  • Jungyeon Kim, Hiroka Kobayashi, Marin Yokomine, Yota Shiratori, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Daisuke Kuroda, Kouhei Tsumoto, Jumpei Morimoto, et al. Residue-based program of a β-peptoid twisted strand shape via a cyclopentane constraint. Organic & biomolecular chemistry. 2022
  • Yoshimitsu Itoh, Shuo Chen, Ryota Hirahara, Takeshi Konda, Tsubasa Aoki, Takumi Ueda, Ichio Shimada, James J Cannon, Cheng Shao, Junichiro Shiomi, et al. Ultrafast water permeation through nanochannels with a densely fluorous interior surface. Science (New York, N.Y.). 2022. 376. 6594. 738-743
  • Shun Kaneko, Shunsuke Imai, Nobuaki Asao, Yutaka Kofuku, Takumi Ueda, Ichio Shimada. Activation mechanism of the mu-opioid receptor by an allosteric modulator. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022. 119. 16. e2121918119
  • Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Yota Shiratori, Daisuke Kuroda, Takumi Ueda, Koh Takeuchi, Kouhei Tsumoto, Shinsuke Sando. Oligo(N-methylalanine) as a Peptide-Based Molecular Scaffold with a Minimal Structure and High Density of Functionalizable Sites. Angewandte Chemie (International ed. in English). 2022. 61. 14. e202200119
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MISC (103):
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Professional career (1):
  • 薬学博士 (東京大学大学院薬学系研究科)
Work history (2):
  • 2019/05 - 現在 Graduate School of Pharmaceutical Sciences, The University of Tokyo Division of Physical Chemistry Associate Professor
  • 2007/01 - 2019/04 The University of Tokyo
Association Membership(s) (4):
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN ,  日本蛋白質科学会
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