Research theme for competitive and other funds (7)：
2021 - 2024 ミトコンドリア病の未知の病態形成機構の解明
2021 - 2023 加齢に伴う生殖系列からの変異型ミトコンドリアDNA消失機構の解明
2018 - 2021 Elucidation of mechanisms of neurodegeneration by reversible regulation of mitochondrial dynamics
2016 - 2019 ミトコンドリアDNAのランダムな突然変異が呼吸欠損を誘導する理由
2016 - 2017 An approach from crosstalks of nuclei-mitochondria to disease mechanisms of mitochondrial diseases
2011 - 2016 Multidirectional evolution of mitochondria
2014 - 2016 マトリョーシカ型進化原理
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Papers (54)：
Hagihara, Hideo, Shoji, Hirotaka, Hattori, Satoko, Sala, Giovanni, Takamiya, Yoshihiro, Tanaka, Mika, Ihara, Masafumi, Shibutani, Mihiro, Hatada, Izuho, Hori, Kei, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. 2024. 12
Ishikawa, Kaori, Honma, Yo, Yoshimi, Ayami, Katada, Shun, Ishihara, Takaya, Ishihara, Naotada, Nakada, Kazuto. Pearson syndrome-like anemia induced by accumulation of mutant mtDNA and anemia with imbalanced white blood cell lineages induced by Drp1 deletion in a murine model. PHARMACOLOGICAL RESEARCH. 2022. 185. 106467-106467
Tani, Haruna, Ishikawa, Kaori, Tamashiro, Hiroaki, Ogasawara, Emi, Yasuikawa, Takehiro, Matsuda, Shigaru, Shimizu, Akinori, Kang, Dongchon, Hayashi, Jun-Ichi, Wei, Fan-Yan, et al. Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation. NUCLEIC ACIDS RESEARCH. 2022. 50. 16. 9382-9396
S, Horibe, K, Ishikawa, K, Nakada, M, Wake, N, Takeda, T, Tanaka, S, Kawauchi, N, Sasaki, Y., Rikitake, Rikitake, Y, et al. Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells. ONCOLOGY REPORTS. 2022. 47. 2. 32
Kishita, Yoshihito, Ishikawa, Kaori, Nakada, Kazuto, Hayashi, Jun-Ichi, Fushimi, Takuya, Shimura, Masaru, Kohda, Masakazu, Ohtake, Akira, Murayama, Kei, Okazaki, Yasushi. A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome. SCIENTIFIC REPORTS. 2021. 11. 1
