Rchr
J-GLOBAL ID：201401012563139524   Update date: Feb. 01, 2024

Horikoshi Naoki

ホリコシ ナオキ | Horikoshi Naoki
Affiliation and department：
The University of Tokyo Institute for Quantitative Biosciences

About The University of Tokyo Institute for Quantitative Biosciences


Job title： Associate Professor
Research field  (2)： Molecular biology ,  Structural biochemistry
Research keywords  (2)： クロマチン、エピジェネティクス、レドックスシグナリング、酵素異常症、血液疾患、がん、クライオ電子顕微鏡解析、X線結晶構造解析、創薬化学、ハイスループットスクリーニング ,  血液疾患、がん、X線結晶構造解析、クライオ電子顕微鏡解析、創薬化学、ハイスループットスクリーニング
Research theme for competitive and other funds  (4)：
  • 2022 - 2025 構造生物化学と定量解析を駆使した滑膜肉腫発生機構の解明と創薬
  • 2022 - 2025 細胞核膜近傍におけるクロマチンの機能・構造解明
  • 2020 - 2022 溶血性貧血の原因となる代謝疾患G6PD欠乏症における酵素活性化と活性化機構の解明
  • 2019 - 2021 溶血性貧血の原因となる代謝疾患G6PD欠乏症の構造基盤
Papers (48)：
  • Syota Matsumoto, Naoki Horikoshi, Yoshimasa Takizawa, Hitoshi Kurumizaka. Chromatin structure related to oncogenesis. Cancer science. 2023. 114. 8. 3068-3075
  • Shin Morioka, Shoko Sato, Naoki Horikoshi, Tomoya Kujirai, Takuya Tomita, Yudai Baba, Takahiro Kakuta, Tomoki Ogoshi, Leonardo Puppulin, Ayumi Sumino, et al. High-Speed Atomic Force Microscopy Reveals Spontaneous Nucleosome Sliding of H2A.Z at the Subsecond Time Scale. Nano Letters. 2023
  • Naoki Horikoshi, Hitoshi Kurumizaka. Structural insight into replicative helicase loading in Escherichia coli. The Journal of Biochemistry. 2022
  • Kaiming Zhang, Naoki Horikoshi, Shanshan Li, Alexander S. Powers, Mikhail A. Hameedi, Grigore D. Pintilie, Hee-Don Chae, Yousuf A. Khan, Carl-Mikael Suomivuori, Ron O. Dror, et al. Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. ACS Central Science. 2022
  • Adriana Ann Garcia, Irimpan I Mathews, Naoki Horikoshi, Tsutomu Matsui, Manat Kaur, Soichi Wakatsuki, Daria Mochly-Rosen. Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants. The Journal of biological chemistry. 2022. 101610-101610
ｍore...
MISC (5)：
  • 岩崎憲治, 堀越直樹, 谷一寿, 宮ノ入洋平, 古寺哲幸, HENGPHASATPORN Kowi, 高橋花南, 韓叡佳, 渋谷綾音, 鈴木理惠, et al. 天然変性タンパク質が引き起こす希少がん発症機構の解明と創薬への取組. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
  • 高橋花南, 古寺哲幸, 宮ノ入洋平, 加藤広介, 堀越直樹, 胡桃坂仁志, 竹中聡, 岩崎憲治. A novel function of synovial sarcoma associated protein SS18-SSX1. 日本薬学会年会要旨集(Web). 2022. 142nd
  • 高橋花南, 堀越直樹, 谷一寿, 宮ノ入洋平, 古寺哲幸, 西村正宏, 加藤広介, 竹中聡, 胡桃坂仁志, 岩崎憲治. 天然変性タンパク質SSX1の新規機能が引き起こす滑膜肉腫発生メカニズム. 日本生化学会大会(Web). 2022. 95th
  • HORIKOSHI,Naoki. エボラウイルスの複製阻害物質の同定と薬剤への応用. Farumashia. 2019. 55. 7. 701-701
  • 越阪部 晃永, 堀越 直樹, 立和名 博昭, 香川 亘, 安田 武嗣, 花岡 文雄, 菅澤 薫, 岩井 成憲, 胡桃坂 仁志. 紫外線損傷DNAを含むヌクレオソームの生化学的および構造生物学的解析. 日本生化学会大会プログラム・講演要旨集. 2013. 86回. 2T14a-07
Lectures and oral presentations  (23)：
  • Structural basis of the glucose-6-phosphate dehydrogenase deficiency
    (2019)
  • Identification and development of small molecule compounds targeting enzymes and protein-protein interactions associated with blood disorders.
    (TARA International symposium: Biological and Structural Mechanisms of Cellular Dynamics 2019)
  • Development of inhibitors to target CREB function in acute myeloid leukemia
    (The 4th Annual Stanford ChEM-H Postdoctoral Fellow Retreat 2018)
  • Structural stability and function of the nucleosome containing H2A.Z in transcription regulation
    (The 4th Histone Variant Meeting 2017)
  • Structural and function of nucleosomes containing H2A.Z.
    (Cold Spring Harbor Asia Conference, CHROMATIN, EPIGENETICS & TRANSCRIPTION 2016)
ｍore...
Education (3)：
  • 2011 - 2014 Waseda University Graduate School of Advanced Science and Engineering
  • 2009 - 2011 Waseda University Graduate School of Advanced Science and Engineering
  • 2005 - 2009 Waseda University School of Science and Engineering
Professional career (1)：
  • 博士(理学) (早稲田大学)
Work history (6)：
  • 2021/04 - 現在 The University of Tokyo
  • 2019/04 - 2021/03 University of Tsukuba
  • 2019/06 - 2021/01 SLAC National Accelerator Laboratory Biological Sciences Division Visiting Scientist
  • 2019/04 - 2021/01 Stanford University School of Medicine, Department of Structural Biology Visiting Assistant Professor
  • 2017/07 - 2019/03 Stanford University School of Medicine, Department of Structural Biology Postdoctoral Research Fellow
Show all
Awards (2)：
  • 2013/09 - 日本生化学会 第86回日本生化学会大会鈴木紘一メモリアル賞
  • 2012/05 - 日本エピジェネティクス研究会 第6回日本エピジェネティクス研究会年会ポスター賞
Association Membership(s) (5)：
The Protein Society ,  American Society for Biochemistry and Molecular Biology ,  The Molecular Biology Society of Japan ,  The Japanese Society for Epigenetics ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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