Yamakado Hodaka

Affiliation and department：
Job title： Research Associate Professor

Research field (1)： Neurology

Research keywords (6)：プリオン , α-シヌクレイン , バイオマーカー , 動物モデル , 多系統萎縮症 , パーキンソン病

Research theme for competitive and other funds (11)：

2023 - 2026 Basic technology of lipid membrane immunosensor for detection of pathogenic protein in blood contributing to ultra-early diagnosis of dementia
2023 - 2025 Elucidation of the pathogenesis and development of disease-modifying therapies targeting neurodegenerative disorders by proteolytic system
2020 - 2024 パーキンソン病関連疾患のモデル作製と治療薬開発
2020 - 2024 Fundamental study on bioelectronic chip for diagnosis of pathologic conditions based on specific and ultrahighly sensitive detection of prion-like protein
2020 - 2023 Investigation of the pathogenesis and the development of therapeutics of neurodegenerative disorders with cell-type specific liposome and exosome

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Papers (65)：

Ryoko Kobayashi, Kotaro Kamitani, Masanori Sawamura, Hodaka Yamakado, Ryosuke Takahashi, Masayuki Sohgawa, Minoru Noda. A Rapid, Sensitive, and Specific Detection of Aggregated α-Synuclein by a Liposome-Immobilized Cantilever Sensor. IEEE Sensors Journal. 2023. 23. 12. 12495-12502
Masanori Sawamura, Junichiro Ohira, Rie Hikawa, Tomoyuki Ishimoto, Etsuro Nakanishi, Hodaka Yamakado, Ryosuke Takahashi. Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs. Parkinsonism & related disorders. 2023. 112. 105440-105440
Tatsuya Ikenoue, Miki Oono, Masatomo So, Hodaka Yamakado, Toshiaki Arata, Ryosuke Takahashi, Yasushi Kawata, Hiroaki Suga. A RaPID Macrocyclic Peptide That Inhibits the Formation of α-Synuclein Amyloid Fibrils. Chembiochem : a European journal of chemical biology. 2023. e202300320
Jun Ueda, Norihito Uemura, Tomoyuki Ishimoto, Tomoyuki Taguchi, Masanori Sawamura, Etsuro Nakanishi, Masashi Ikuno, Shuichi Matsuzawa, Hodaka Yamakado, Ryosuke Takahashi. Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission. Movement disorders. 2023
Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, et al. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nature communications. 2022. 13. 1. 6880-6880

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MISC (9)：

引網亮太, 端祐一郎, 山門穂高, 辰己新水, 山下博史, 澤本伸克, 辻輝之, 川本未知, 幸原伸夫, 井上治久, et al. FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像:若年発症例を含む4症例の検討. 56th Annual Meeting of the Japanese Society of Neurology, Niigata. 2015
Yasushi Koshiba, Hodaka Yamakado, Asuka Morizane, Tetsuhiro Kikuchi, Kazuko Hasegawa, Haruhisa Inoue, Jun Takahashi, Ryosuke Takahashi. iPS cell modeling of genetic Parkinson's disease. MOVEMENT DISORDERS. 2014. 29. S68-S68
N. Uemura, H. Matsui, T. Fujiwara-Ishikawa, M. Kinoshita, M. Koike, H. Yamakado, K. Uemura, Y. Uchiyama, T. Todo, S. I. Takeda, et al. Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain. MOVEMENT DISORDERS. 2013. 28. S373-S374
H. Yamakado, Y. Moriwaki, N. Yamasaki, T. Miyakawa, J. Kurisu, K. Uemura, H. Inoue, M. Takahashi, R. Takahashi. alpha-synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior. MOVEMENT DISORDERS. 2012. 27. S498-S498
Roberto Gavinio, Hodaka Yamakado, Tomoyo Sawada, Makio Takahashi, Ryosuke Takahashi. Pael-R, a substrate of Parkin, can also be cleared by PINK1. NEUROSCIENCE RESEARCH. 2011. 71. E192-E192

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Lectures and oral presentations (15)：

神経変性疾患における中枢-末梢病態連関
(第46回神経科学大会(シンポジウム) 2023)
パーキンソン病に伴う自律神経障害
(第75回日本自律神経学会総会(シンポジウム) 2022)
Animal model for Parkinson's disease: Strengths and drawbacks
(UK-Japan Neuroscience Symposium 2022)
多系統萎縮症の病態はどこまで分かったか?
(第16回MDSJ(教育講演) 2022)
Animal model of Parkinson's disease: For unveiling the pathogenesis and the develpment of DMT
(2022)

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Education (2)：

Professional career (1)：

Work history (8)：

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