Research field (2)：
Molecular biology
, Functional biochemistry
Research keywords (5)：
Ubiquitin
, Proteasome
, Protein degradation
, MS-based proteomics
, LLPS
Research theme for competitive and other funds (24)：
2023 - 2028 Integrated understanding of proteasomal degradation and the ubiquitin code
2023 - 2028 Shin-biology regulated by protein lifetime
2023 - 2028 Mechanism of how the proteasome determines protein lifetime
2023 - 2024 New Frontier for Ubiquitin Biology Driven by Chemo-technologies
2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
2018 - 2023 Decryption of the ubiquitin code by chemo-technologies and advanced proteomics
2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
2018 - 2022 Elucidation of protein networks controlling proteasomal degradation
2017 - 2019 Elucidation of degradation signals presented on aberrant nascent polypeptides
2014 - 2018 Roles of Nedd4-IRS complexes in the development of diabetes and cancer
2014 - 2018 Formation mechanism and physiological significance of proteasome speckle
2013 - 2018 Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex
2015 - 2017 Elucidation of the mechanism for nuclear export of the proteasome
2012 - 2017 New aspect of the ubiquitin system : its enormous roles in protein regulation
2012 - 2017 Development of biochemical methods to understand protein ubiquitylation
Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024
Takumi Ito, Tomoko Asatsuma-Okumura, Akinori Endo, Junichi Yamamoto, Yoshiko Iwai, Yuki Yamaguchi, Mikihiko Naito, Hiroshi Handa, Yasushi Saeki. ZNF276 and WIZ are CRBN neosubstrates involved in the anti-angiogenic activity of thalidomide and immunomodulatory drugs. 2023
Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda, et al. An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants. Frontiers in Microbiology. 2022. 13. 967019-967019
Yoshino Akizuki, Mai Morita, Yuki Mori, Ai Kaiho-Soma, Shivani Dixit, Akinori Endo, Marie Shimogawa, Gosuke Hayashi, Mikihiko Naito, Akimitsu Okamoto, et al. cIAP1-based degraders induce degradation via branched ubiquitin architectures. Nature chemical biology. 2022. 19. 3. 311-322
