Tsuchiya Kohsuke

ツチヤコウスケ | Tsuchiya Kohsuke

Affiliation and department：
Job title：准教授

Research field (3)： Immunology , Bacteriology , Tumor biology

Research theme for competitive and other funds (9)：

2023 - 2027 細菌由来分子を認識する新たなパターン認識受容体の機能解析と応用
2022 - 2025 Identification of Bacterial and Fungal Proteases that Activate Gasdermin Family Molecules to cause Pyroptosis
2020 - 2023 パイロトーシス細胞が放出するリステリア増殖抑制因子の解析
2018 - 2021 Host-pathogen interactions in antibiotic therapy for listeriosis
2014 - 2019 Molecular mechanisms and roles of pyroptosis

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Papers (41)：

Kohei Ogura, Maho Endo, Takashi Hase, Hitomi Negami, Kohsuke Tsuchiya, Takumi Nishiuchi, Takeshi Suzuki, Kazuhiro Ogai, Hiromi Sanada, Shigefumi Okamoto, et al. Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case-control study. Clinical Proteomics. 2023. 20. 1
Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Yu Oshima, Kohsuke Tsuchiya, Shin Murai, Chiaki Takahashi, Michihiro Matsumoto, Shigetaka Kitajima, et al. The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice. Nature Communications. 2023. 14. 1
Yuko Tanishita, Hisateru Sekiya, Naohiro Inohara, Kohsuke Tsuchiya, Masao Mitsuyama, Gabriel Núñez, Hideki Hara. Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion. Cell Reports. 2022. 38. 8
Takayuki Uematsu, Kohsuke Tsuchiya, Noritada Kobayashi, Motoharu Seiki, Jun ichiro Inoue, Shuichi Kaneko, Takeharu Sakamoto. Mint3 depletion-mediated glycolytic and oxidative alterations promote pyroptosis and prevent the spread of Listeria monocytogenes infection in macrophages. Cell Death and Disease. 2021. 12. 4
Kohsuke Tsuchiya, Shoko Hosojima, Hideki Hara, Hiroko Kushiyama, Mamunur Rashid Mahib, Takeshi Kinoshita, Takashi Suda. Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes. Cell Reports. 2021. 34. 12

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MISC (9)：

Kohsuke Tsuchiya, Muhammad Mamunur Rashid Mahib, Takashi Suda. Caspase-1 serves as an apoptosis-initiating caspase in the absence of Gasdermin D (GSDMD). CYTOKINE. 2017. 100. 98-98
Inhibition of the NLRP3 inflammasome by nitric oxide. 2013. 60. 6. 611-618
Kohsuke Tsuchiya, Eduardo Hernandez-Cuellar, Hideki Hara, Rendong Fang, Shunsuke Sakai, Ikuo Kawamura, Masao Mitsuyama. Nitric oxide inhibits the NLRP3 inflammasome. JOURNAL OF IMMUNOLOGY. 2013. 190
Involvement of AIM2 (absent in melanoma 2) in the activation of inflammasome. 2011. 62. 3. 202-207
土屋晃介, 野村卓正, 原英樹, 河村伊久雄, 光山正雄. リステリアの細胞内殺菌抵抗性におけるActAの新たな役割. 日本細菌学雑誌. 2007. 62. 1. 122-122

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Books (3)：

Professional career (1)：

Committee career (1)：

Awards (1)：

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