Woltjen Knut

Affiliation and department：
Job title： Associate Professor

Research field (6)： Genetics , Developmental biology , Cell biology , Medical biochemistry , Molecular biology , Genomics

Research keywords (9)：遺伝子ターゲティング , SNP , pluripotent stem cells , transposons , recombinases , CRISPR , iPS cells , molecular genetics , genome editing

Research theme for competitive and other funds (7)：

2021 - 2024 肺オルガノイドを用いた呼吸器病原体の革新的研究基盤の構築と病原性発現機序の解明
2021 - 2024 Evaluating the role of cis-regulatory tandem DNA repeats in human disease and evolution
2021 - 2024 Developing a versatile technique to create transgenic rodents and medium sized animals
2021 - 2023 Regulation of gene expression revealed by genome editing of repetitive and polymorphic cis-elements
2017 - 2020 Establishment of universal iPS cells for regenerative medicine applications through regulated HLA expression

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Papers (83)：

Ryo Niwa, Tomoko Matsumoto, Alexander Yusuke Liu, Maki Kawato, Takayuki Kondo, Kayoko Tsukita, Haruhisa Inoue, Thomas Luc Maurissen, Knut Woltjen. Enrichment of allelic editing outcomes by Prime Editing in iPS cells. 2024
Eiichi Okamura, Seiya Mizuno, Shoma Matsumoto, Kazuya Murata, Yoko Tanimoto, Dinh Thi Huong Tra, Hayate Suzuki, Woojin Kang, Tomoka Ema, Kento Morimoto, et al. Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation. 2023
Takumi Okubo, Nicolas Rivron, Mio Kabata, Hideki Masaki, Keiko Kishimoto, Katsunori Semi, May Nakajima-Koyama, Haruko Kunitomi, Belinda Kaswandy, Hideyuki Sato, et al. Hypoblast from human pluripotent stem cells regulates epiblast development. Nature. 2023
Shunsuke Kawasaki, Hiroki Ono, Moe Hirosawa, Takeru Kuwabara, Shunsuke Sumi, Suji Lee, Knut Woltjen, Hirohide Saito. Programmable mammalian translational modulators by CRISPR-associated proteins. Nature Communications. 2023. 14. 1
Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, et al. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. Arrhythmia and electrophysiology. 2023. 16. 3. e011387

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MISC (14)：

上田樹, 入口翔一, 河合洋平, 南川淳隆, 三好浩之, 寺倉精太郎, 植村靖史, 中面哲也, 玉田耕治, ウォルツェン・クヌート, et al. 正しい分化経路をたどったiPS細胞由来T細胞は固形腫瘍に対して優れた集積性および治療効果を示す. 日本がん免疫学会総会プログラム・抄録集. 2018. 22回. 70-70
上田樹, 入口翔一, 河合洋平, 南川淳隆, 三好浩之, 寺倉精太郎, 植村靖史, ウォルツェン・クヌート, 児玉裕三, 玉田耕治, et al. GPC3を標的としたiPS細胞由来CAR-T療法. 日本癌学会総会記事. 2017. 76回. P-1251
金永輝, Elalaf Hassan, 渡辺真, 玉置さくら, 日根野翔, 松永一仁, Woltjen Knut, 岡本健, 松田秀一, 戸口田淳也. 変異型IDH1は遺伝子特異的なヒストン修飾を介して、間葉系幹細胞から軟骨及び骨への分化を脱制御する. 日本癌学会総会記事. 2016. 75回. J-2044
金永輝, Elalaf Hassan, 渡辺真, 玉置さくら, 日根野翔, 松永一仁, Woltjen Knut, 岡本健, 松田秀一, 戸口田淳也. 変異型IDH1は遺伝子特異的なヒストン修飾を介して、間葉系幹細胞から軟骨及び骨への分化を脱制御する. 日本癌学会総会記事. 2016. 75回. J-2044
金永輝, Elalaf Hassan, 渡辺真, 玉置さくら, 日根野翔, 松永一仁, Woltjen Knut, 岡本健, 松田秀一, 戸口田淳也. 変異型IDH1は骨・軟骨関連遺伝子のヒストンを遺伝子特異的に修飾し、間葉系幹細胞の分化能を脱制御する. 日本癌学会総会記事. 2015. 74回. J-1287

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Patents (1)：

Method for genome editing

Books (1)：

iPS細胞を用いた正確なゲノム編集法(MhAX法)
実験医学 2018

Lectures and oral presentations (32)：

Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining
(2019 Keystone Symposia 『Genome Engineering: From Mechanisms to Therapies (B4)』 2019)
The history and potential of iPSC research
(AAAS 2019 Annual Meeting 2019)
医療応用に向けたヒトiPS細胞でのゲノム編集
(OPERA「ゲノム編集」産学共創コンソーシアム・公開シンポジウム、卓越大学院キックオフシンポジウム 2018)
Japan’s experience in regenerative medicine and superdonor cells
(NRC’s HEALTH CHALLENGE PROGRAM WORKSHOP : ‘Transforming Health Outcomes through Engineered Cell and Gene Therapies’ 2018)
Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining
(Concordia University Seminar 2018)

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Education (3)：

2000 - 2006 University of Calgary Dept. Biochemistry and Molecular Biology, Doctoral Research Program
1998 - 2000 University of Calgary Dept. Biochemistry and Molecular Biology, Masters Research Program
1994 - 1998 University of Alberta Dept. of Biological Sciences, Faculty of Genetics, Molecular Genetics Program

Professional career (1)：

博士(Biochemistry and Molecular Biology) (カルガリー大学)

Work history (6)：

2013/04 - 2018/03 Kyoto University Center for iPS Cell Research and Application (CiRA)/ Hakubi Center for Advanced Research Associate Professor
2010/04 - 2013/03 Kyoto University Center for iPS Cell Research and Application (CiRA) Assistant Professor
2009/02 - 2010/03 Ontario Human iPS Cell Facility The Hospital For Sick Children iPS Cell Facility Manager
2006/09 - 2010/03 Mount Sinai Hospital, Samuel Lunenfeld Research Institute Dr. Andras Nagy Lab Postdoctoral Research Fellow
2005/01 - 2006/08 University of Calgary Centre for Mouse Genomics Molecular/Gene Targeting Consultant

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Committee career (4)：

2018/07 - 現在 Japanese Society for Genome Editing International Committee
2018/07 - 現在日本ゲノム編集学会国際委員会委員
2016/07 - 現在 Japanese Society for Genome Editing Public Relations Committee
2016/07 - 現在日本ゲノム編集学会広報委員会委員

Awards (1)：

2020/01 - CiRA, Kyoto University 7th Annual CiRA Award For remarkable contributions to collaborative research

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