IYORI MITSUHIRO

イヨリミツヒロ | IYORI MITSUHIRO

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Research collaborator

Research field (4)： Parasitology , Immunology , Pharmaceuticals - health and biochemistry , Applied microbiology

Research keywords (6)：血清疫学 , 抗血小板薬 , Viral vectors , Mosquitoes , Vaccine , Malaria

Research theme for competitive and other funds (24)：

2022 - 2025 Development of Plasmodium vivax vaccine effective both for protection and transmission blocking
2021 - 2024 インドネシア人の血清疫学調査に基づくCOVID-19ワクチンの開発研究
2021 - 2024 認可済みウイルスベクターを基盤とした感染防御-伝搬阻止マラリアワクチンの開発研究
2019 - 2022 Evaluation of innate immune resonses induced by baculovirus against malaria liver-stage parasites
2020 - 2022 Made-in-Japan next-generation vaccine platform effective for multistage Plasmodium for infants

2020 - 2022 次世代マラリアワクチンの探索

2018 - 2021 The development of a novel vaccine vector by the heterologous prime-boost immunization regimen

2019 - 2021 臨床応用を目指したアデノ随伴ウイルスを用いた熱帯熱マラリア2価ワクチンの開発研究

2018 - 2020 Development of a new immunostimulatory drug for non-haemolytic alternative to PQ.

2016 - 2019 Development of a new evaluation tool for measuring malaria infection risk based on antibody responses to Anopheles saliva protein

2015 - 2018 Malaria vaccine development based on multifunctional hybrid vaccine platform

2016 - 2018 臨床試験に向けての新規マラリアワクチンBDES-NPVの製造プロセスと品質管理に関する研究

2015 - 2017 Anopheline anti-platelet protein, AAPP, regulates probing time and blood feeding success in the malaria vector mosquito, Anopheles stephensi

2014 - 2017 The development of malaria vaccine platform using baculovirus regulating immune responses

2016 - 2017 マラリアワクチン開発を基盤とした新規感染症用ワクチンプラットフォームの創出 -非感染性バキュロウイルスナノ粒子ワクチンシステムの開発研究

2013 - 2016 IgG responses to mosquito saliva proteins for evaluating human exposure to Anopheles bites

2015 - 2016 非感染性ウイルスナノ粒子ワクチンを用いたマラリアワクチン開発

2014 - 2016 補体抵抗性を付与した新型マラリアワクチンベクターの開発

2012 - 2014 Development of a novel anti-platelet drug targeted for collagen-induced platelet aggregation

2013 - 2014 抗蚊唾液抗体価を用いたマラリア疫学調査の新規評価法の開発

2012 - 2013 出血助長の副作用を回避した新規低分子化ペプチドの抗血小板薬開発研究

2012 - 2013 新規マラリアワクチンベクター Baculovirus Triple Expression Systemの研究開発

2011 - 2012 吸血昆虫由来の新規ペプチドを基盤とした抗血小板薬の開発

2008 - 2009 Toll様受容体とナチュラルキラー細胞受容体とのクロストーク

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Papers (29)：

Sitti Nurisyah, Mitsuhiro Iyori, Ammar A. Hasyim, Akihiko Sakamoto, Hinata Hashimoto, Kyouhei Yamagata, Saya Yamauchi, Khaeriah Amru, Kartika H. Zainal, Irfan Idris, et al. Comparison between neutralization capacity of antibodies elicited by COVID-19 natural infection and vaccination in Indonesia: A prospective cohort. Antibodies. 2023. 12. 3. 60
水野哲志, Andrew Blagborough, 新倉保, 伊從光洋, 水上浩明, 志田壽利, 吉田栄人. 複数ライフステージをワクチンターゲットにした熱帯熱マラリアワクチンの開発. 臨床とウイルス. 2023. 51. 3. 126-126
Nobuko Tuno, Thahsin Farjana, Yui Uchida, Mitsuhiro Iyori, Shigeto Yoshida. Effects of Temperature and Nutrition during the Larval Period on Life History Traits in an Invasive Malaria Vector Anopheles stephensi. Insects. 2023. 14. 6
Mitsuhiro Iyori, Andrew M. Blagborough, Tetsushi Mizuno, Yu-ichi Abe, Mio Nagaoka, Naoto Hori, Iroha Yamagoshi, Dari F. Da, William F. Gregory, Ammar A. Hasyim, et al. Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study. Frontiers in Immunology. 2022. 13. 1005476-1005476
Akihiko Sakamoto, Hiroaki Osawa, Hinata Hashimoto, Tetsushi Mizuno, Ammar A. Hasyim, Yu-ichi Abe, Yuto Okahashi, Ryohei Ogawa, Mitsuhiro Iyori, Hisatoshi Shida, et al. A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine. Emerging Microbes & Infections. 2022. 1-40

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MISC (9)：

Mitsuhiro Iyori, Andrew M. Blagborough, Sota Ogata, Hidesato Nishiura, Miako Sakaguchi, Masanori Mizutani, Takahiko Tamura, Kento Genshi, Satoshi Shimada, Daisuke S. Yamamoto, et al. VECTORED PFCSP VACCINES BASED ON BACULOVIRUS DUAL EXPRESSION SYSTEM AND ADHU5 INDUCE STRONG PROTECTIVE EFFICACY AGAINST TRANSGENIC PLASMODIUM BERGHEI. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017. 95. 5. 125-125
Kunitaka Yoshida, Ahmed M. Salman, Pawan Dulal, Shahid M. Khan, Chris J. Janse, Sumi Biswas, Masaharu Tokoro, Mitsuhiro Iyori, Shigeto Yoshida, Adrian V. S. Hill. ENHANCED PROTECTIVE EFFICACY OF A PLASMODIUM FALCIPARUM MALARIA VACCINE USING A HETEROLOGOUS PRIME-BOOST IMMUNIZATION WITH A BACULOVIRAL VACCINE AND CHAD63 EXPRESSING PFCSP AGAINST CHALLENGE WITH TRANSGENIC P. BERGHEI SPOROZOITES. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017. 95. 5. 314-314
Mitsuhiro Iyori, Risa Fujiyoshi, Din Syafrudin, Shigeto Yoshida. DIFFERENTIAL ANTIBODY RESPONSE TO THE ANOPHELES STEPHENSI AAPP AND PLASMODIUM ANTIGENS IN INDIVIDUALS NATURALLY EXPOSED TO BITES OF AFROTROPICAL MALARIA VECTORS. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015. 93. 4. 114-114
Mohammad Shamsul Haque, 長谷部晃, 伊従光洋. Clathrin-dependent endocytosis of the TLR2 ligand FSL-1 triggered by CD14 and CD36 but not by TLR2 (第36回日本マイコプラズマ学会学術集会). 日本マイコプラズマ学会雑誌. 2009. 36. 1-3
OHTANI Makoto, IYORI Mitsuhiro, HASEBE Akira, KIURA Kazuto, TOTUKA Yasunori, SHIBATA Ken-ichiro. Cross talk between Toll-like receptor 2- and DC-SIGN-mediated signaling pathways. 2008. 35. 65-66

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Lectures and oral presentations (159)：

Analysis of gene expression in the liver stimulated by baculovirus for killing the liver-stage Plasmodium
(The 16th Asian-Pacific Congress for Parasitic Zoonoses 2023)
Development of a malaria vaccine in animal models
(The 16th Asian-Pacific Congress for Parasitic Zoonoses 2023)
三日熱マラリア撲滅へ向けて〜次世代型ウイルスベクター(LC16m8Δ/AAV)を用いた三日熱マラリアマルチステージワクチン開発研究〜
(日本薬学会北陸支部第135回例会 2023)
P. falciparum-P. vivax bivalent vaccine development using LC16m8Δ/AAV viral vectors platform achieves sterile protection and transmission blocking
(ASTMH 2023 Annual Meeting 2023)
Humoral immune responses to the central repeat region of PfCSP induced by a viral-vectored plasmodium falciparum vaccine play critical roles in protection in a murine model
(ASTMH 2023 Annual Meeting 2023)

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Education (2)：

2005 - 2009 Hokkaido University Graduate School of Dental Medicine
1998 - 2005 Hokkaido University School of Dental Medicine

Work history (6)：

2022/04 - 現在 Musashino University Faculty of Pharmacy Department of Pharmaceutical Sciences Professor
2022/04 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Research collaborator
2015/10 - 2022/03 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Associate Professor
2011/02 - 2015/09 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Assistant Professor
2009/08 - 2011/01 Dartmouth University Postdoctoral Fellow

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Committee career (6)：

2020/04 - 現在日本寄生虫学会評議員
2018/04 - 現在薬学教育協議会微生物学教科担当教員
2019 - 第75回日本寄生虫学会西日本支部大会事務局統括
2018 - 日本薬学会第138年会実行委員
2017 - 日本薬学会北陸支部例会実行委員/事務局統括

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Awards (1)：

2009/03 - 北海道大学大学院歯学研究科北海道歯学会賞

Association Membership(s) (6)：

日本薬学会 , 日本衛生動物学会 , 日本寄生虫学会 , 日本免疫学会 , 日本マイコプラズマ学会 , 日本細菌学会

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