Yoshimi Kazuto

ヨシミカズト | Yoshimi Kazuto

Affiliation and department：
Job title： Associate professor

Research field (2)： Genomics , Laboratory animal science

Research keywords (6)： mouse , disease model , humanized , rat , genome editing , CRISPR/Cas

Research theme for competitive and other funds (13)：

2023 - 2028 Type I CRISPR ゲノム編集機構の解明に基づく新規遺伝子編集法の開発
2022 - 2025 Integrative Structural Biology Studies on the development for safe and efficient Cas3 genome editing tools
2022 - 2025 過去の細胞状態の記録による神経炎症ミクログリアの時空間的解析
2022 - 2024 時空間制御CRISPR-Cas3の開発および生体内ゲノム改変への応用
2019 - 2022 In vivo genomic engineering with a novel genome editing tools

Show all

Papers (36)：

Ryuya Iida, Saeko Ishida, Jinxi Wang, Kosuke Hattori, Kazuto Yoshimi, Satoshi Yamazaki, Tomoji Mashimo. A novel Kit mutant rat enables hematopoietic stem cell engraftment without irradiation. Experimental hematology. 2024. 132. 104174-104174
Masayuki Mori, Jian Dai, Hiroki Miyahara, Ying Li, Xiaojing Kang, Kazuto Yoshimi, Tomoji Mashimo, Keiichi Higuchi, Kiyoshi Matsumoto. Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner. Experimental animals. 2023. 72. 2. 233-241
Kazuto Yoshimi, Tomoji Mashimo. Genome editing technology and applications with the type I CRISPR system. Gene and Genome Editing. 2022. 3-4. 100013-100013
Jun-Ya Kaimori, Yamato Kikkawa, Daisuke Motooka, Tomoko Namba-Hamano, Ayako Takuwa, Atsuko Imai-Okazaki, Kaori Kobayashi, Arisa Tanigawa, Yuko Kotani, Yoshihiro Uno, et al. A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects. JCI insight. 2022. 7. 23
Kazuto Yoshimi, Kohei Takeshita, Noriyuki Kodera, Satomi Shibumura, Yuko Yamauchi, Mine Omatsu, Kenichi Umeda, Yayoi Kunihiro, Masaki Yamamoto, Tomoji Mashimo. Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3. Nature communications. 2022. 13. 1. 4917-4917

ｍore...

MISC (31)：

吉見一人. タイプI CRISPRを用いたゲノム編集技術. 生化学. 2023. 95. 6. 818-822
吉見一人, 真下知士. 【遺伝を考える】(III章)遺伝子操作とゲノム医療 CRISPR-Casシステムゲノム編集と医療への応用. 日本医師会雑誌. 2023. 152. 特別1. S194-S197
渡辺祥司, 吉見一人, 真下知士. 【真の実臨床応用をめざした再生医療2023 リバーストランスレーショナルリサーチのいまと産業化のための技術開発】(第5章)ブレイクスルーとなる基礎的知見と課題 CRISPR-Cas3システムによるゲノム編集国産ゲノム編集技術の再生医療への挑戦. 実験医学. 2023. 41. 2. 331-337
吉見一人, 真下知士. 国産ゲノム編集技術CRISPR-Cas3 遺伝子治療、診断への応用. 再生医療. 2022. 21. 2. 88-91
吉見一人, 真下知士. 国産ゲノム編集技術CRISPR-Cas3:遺伝子治療、診断への応用. 再生医療2022. 2022. 21. 2. 22-25

ｍore...

Patents (9)：

ｍore...

Books (9)：

ｍore...

Lectures and oral presentations (68)：

Genome editing technology and applications with the type I CRISPR system
(2023)
CRISPR-Cas3とは何者?どのようにして使えるのか?
(第46回日本分子生物学会年会バイオテクノロジーセミナー 2023)
Genome editing technology and applications with the type I-E CRISPR system
(JAACT 2023 2023)
Development of a novel genome editing tool, Type I-E CRISPR, and its application in experimental animals
(9th Asian Federation of Laboratory Animal Science Associations Congress 2023 2023)
Molecular mechanism of type I-E CRISPR-Cas3 mediated DNA breaks and its application to genome editing in zygotes
(Genome Engineering: CRISPR Frontiers 2023 at Cold Spring Harbor Laboratory 2023)

ｍore...

Education (2)：

Work history (6)：

2024/01 - 現在 The University of Tokyo The Institute of Medical Science Associate professor
2019/11 - 2023/12 The University of Tokyo Institute of Medical Science (IMSUT) Senior Assistant Professor
2020/10 - 2021/10 ETH Zurich, Molecular Health Sciences Visiting researcher
2017/04 - 2019/10 Osaka University Graduate school of medicine Assistant professor
2015/04 - 2017/03 National Institute of Genetics Assistant professor

Show all

Committee career (6)：

Show all

Awards (6)：

2022/06 - 日本ゲノム編集学会第7回大会ポスター優秀賞タイプI-E CRISPR-Cas3による標的二本鎖DNA切断機構の解明
2018/02 - The 9th Takeda Science Foundation Symposium on PharmaSciences Excellent poster award
2017/09 - 大阪大学医学系第9回若手研究フォーラムベストプレゼンテーション賞
2015/05 - Japanese Association for Laboratory Animal Science Encouragement award
2012/09 - Chinese Association for Laboratory Animal Science International Award for Young Scientists

Show all

Association Membership(s) (5)：

日本ゲノム編集学会 , 関西実験動物研究会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , 日本遺伝学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page