Yoshitomi Hiroyuki

ヨシトミヒロユキ | Yoshitomi Hiroyuki

Affiliation and department：

Research field (1)： Immunology

Research theme for competitive and other funds (12)：

2021 - 2024 Investigation of B-cell immunity against gynecological cancer and new strategies for diagnosis and treatment
2020 - 2024 がん微小環境におけるCXCL13産生T細胞解析を起点としたヒトがん免疫機構解明
2019 - 2022 Investigation of temporospatial dynamics of Sox4 in the pathogenesis of RA
2018 - 2021 Comprehensive understanding of spatio-temporal effects of mutant IDH1 during the development of cartilage forming tumors
2018 - 2021 Mechanism analysis of heterotopic ossification formation in Fibrodysplasia Ossificans Progressiva (FOP)

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Papers (105)：

Hiroyuki Yoshitomi. Peripheral helper T cells, mavericks of peripheral immune responses. International immunology. 2024. 36. 1. 9-16
Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, et al. Monocyte-derived transcriptomes explain the ineffectiveness of abatacept in rheumatoid arthritis. Arthritis research & therapy. 2024. 26. 1. 1-1
Shigeo Yoshida, Kohei Nishitani, Hiroyuki Yoshitomi, Shinichi Kuriyama, Shinichiro Nakamura, Takayuki Fujii, Motoo Saito, Yu Kobori, Akinori Murakami, Koichi Murata, et al. Knee Alignment Correction by High Tibial Osteotomy Reduces Symptoms and Synovial Inflammation in Knee Osteoarthritis Accompanied by Macrophage Phenotypic Change From M1 to M2. Arthritis & rheumatology (Hoboken, N.J.). 2023. 75. 6. 950-960
Akio Umemoto, Takeshi Kuwada, Koichi Murata, Masahiro Shiokawa, Sakiko Ota, Yoshiki Murotani, Akihiro Itamoto, Kohei Nishitani, Hiroyuki Yoshitomi, Takayuki Fujii, et al. Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis research & therapy. 2023. 25. 1. 25-25
Akio Umemoto, Hiromu Ito, Masayuki Azukizawa, Koichi Murata, Masao Tanaka, Takayuki Fujii, Akira Onishi, Hideo Onizawa, Shinichiro Ishie, Akinori Murakami, et al. How do symptoms of each joint contribute to global pain, disease activity and functional disability in rheumatoid arthritis?-A comprehensive association study using a large cohort. PloS one. 2023. 18. 8. e0285227

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MISC (128)：

吉富啓之, 上野英樹. 臨床医が知っておくべき最新の基礎免疫学(最終回)(第23回) ヒト免疫研究の重要性. 医学のあゆみ. 2021. 276. 12. 1139-1144
KAMAKURA Takeshi, JIN Yonghui, TAMAKI Sakura, WATANABE Makoto, WATANABE Makoto, OKAMOTO Takeshi, YOSHITOMI Hiroyuki, TOGUCHIDA Junya, TOGUCHIDA Junya. Mutant IDH1 triggers oncogene-induced senescence in normoxia. 日本整形外科学会雑誌. 2021. 95. 6
吉富啓之, 上野英樹. 【リウマチ性疾患の病態における適応免疫と治療への展望】関節リウマチ病態における適応免疫と治療への展望. リウマチ科. 2020. 64. 5. 511-517
鎌倉武史, 金永輝, 玉置さくら, 渡辺真, 岡本健, 吉富啓之, 戸口田淳也. 変異型IDH1は通常酸素下において癌遺伝子誘導性細胞老化を引き起こす. 日本癌学会総会記事. 2020. 79回. PJ4-6
玉置さくら, 永田早苗, 金永輝, 吉富啓之, 戸口田淳也. 多能性幹細胞を用いたIn vitro肉腫発生機序解明への試み. 日本癌学会総会記事. 2020. 79回. PJ4-7

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Books (8)：

ポストGWAS時代の遺伝統計学 : オミクス解析と機械学習でヒト疾患を俯瞰する
羊土社 2023 ISBN:9784758104104
自己免疫疾患 : 層別化する新時代へ : 臨床検体のマルチオミクス解析、腸内細菌によって見えてきた免疫経路の全容
羊土社 2022 ISBN:9784758104050
夜明けを迎えたヒト免疫学
羊土社 2022 ISBN:9784758125512
臨床医が知っておくべき免疫学のいま
医歯薬出版 2021
難治性免疫疾患病態解明と新規治療戦略
医学のあゆみ・医歯薬出版 2021

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Lectures and oral presentations (24)：

微量検体を用いたシングルセル免疫解析の実際
(第50回日本免疫学会 2021)
関節リウマチにおけるヒトT細胞の分化と機能
(第8回JCRベーシックリサーチカンファレンス 2021)
ヒト自己免疫疾患におけるTph細胞
(第64回日本リウマチ学会総会・学術集会 2020)
異所性リンパ濾胞におけるヘルパーT細胞の病態機構
(第6回T-cell seminar 2019)
Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments
(令和元年日本リウマチ財団学術助成受賞者記念講演 2019)

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Awards (1)：

2019/06 - Japan Rheumatism Foundation Novartis medical award in rheumatoid arthritis Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

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