Rchr

J-GLOBAL ID：201401030566409415 Update date: Feb. 01, 2024

Dezawa Mari

デザワマリ | Dezawa Mari

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.stemcells.med.tohoku.ac.jp/greeting/index.html , http://www.stemcells.med.tohoku.ac.jp/english/greeting/index.html

Research field (1)： Anatomy

Research keywords (3)： Muse Cell , Stem Cells , Regenerative biomedicine

Research theme for competitive and other funds (62)：

2023 - 2026 Basic research on Muse cell transplantation for Duchenne muscular dystrophy
2023 - 2025 正常細胞と病的細胞の光散乱・揺らぎ4次元解析:散乱透視学と医学の融合
2022 - 2025 急性心筋梗塞患者の末梢血で増加するMUSE細胞のプロファイル
2020 - 2024 The novel differentiation method in pluripotent stem cells without using gene introduction or cytokine stimulation.
2020 - 2023 Muse細胞の予防医学応用のための細胞組織疫学研究

2020 - 2023 Muse cell transplantation for spinal cord injury in chronic phase

2020 - 2023 Muse細胞を用いた急性心筋炎の病態解明および新規治療法確立

2019 - 2022 Search for innovative organ transplantation without the need for relatives or HLA matching

2017 - 2020 Platform for regenerative therapy of central nervous system using Muse cells

2016 - 2019 Development of sepsis treatment strategy using Muse cell as stress-tolerant pluripotent stem cells from mesenchymal stem cells

2015 - 2019 Neuronal differentiation of MUSE cells mediated by neuronal differentiation control peptides and application to neuronal regeneration medicine

2015 - 2018 Effects of Multilineage-differentiating stress-enduring (Muse) cells on brain damages induced by Shiga toxin 2 in vivo and in vitro

2015 - 2018 Reconstruction of Neuronal Circuitry by Muse cell transplantation in lacunar stroke

2015 - 2017 Treatment of Lung Ischemia-reperfusion injury by Muse cells

2014 - 2017 Analysis of the functions of MUSE in the lymphoma microenvironment.

2013 - 2017 Genetically-engineered multilineage-differentiating stress-enduring cells as cellular vehicles against malignant gliomas

2015 - 2017 腫瘍性を持たない多能性幹細胞 Muse細胞を用いた新たな肝再生治療

2014 - 2017 生体由来多能性幹細胞Muse細胞の発生学的起源の探索と組織恒常性維持における役割

2013 - 2016 An analysis of the characteristics of Muse cells in mesenchymal cells obtained from umbilical cords, and the development of periodontal regenerative therapy applications

2013 - 2016 Basic and Clinical Aspects of MUSE Cells in Stroke Care

2015 - 2016 Muse細胞を用いた再生医療の実現に向けた製剤製造システムの研究開発

2013 - 2015 肝切除後組織修復に関わるMuse細胞の役割とその臨床応用に向けた基盤構築

2011 - 2014 Isolation of pluriptent somatic stem cells for neuronal regenerative medicine and neuronal differentiation peptide-mediated neuronal differentiation

2013 - 2014 Suggested common mechanism underlying between human Muse cells and planarian neoblasts

2012 - 2014 ヒト生体由来多能性幹細胞(Muse細胞)の再生医療への応用に向けた安全性・有効性の検証

2010 - 2014 Development of a definitive therapy for degenerative neuromuscular diseases using autologous cells and cell banks

2014 - Muse細胞を用いた再生医療の実現に向けた製剤製造システムの研究開発

2011 - 2013 Effects of bone marrow mesenchymal stem cells on encephalopathy caused by Shiga toxin 2c-producing Escherichia coli infection in mice

2011 - 2013 Characterization of Muse cells, non-tumorigenic intrinsic pluripotent stem cells, and their application to regenerative medicine.

2010 - 2013 Muse細胞の評価基盤技術開発に基づく、再生医療に向けた培養・評価装置の研究開発

2011 - 2012 Possibility of transplantation of human skin-derived pluripotent stem cells into the bone marrow

2008 - 2012 Development of Technology to Manipulate the Biological Functions of Stem Cells for Cell Therapy of Next Generation

2009 - 2010 間葉系組織に内包される多分化能細胞の探索

2008 - 2010 Identification of neural induction domain in stem cells and neuronal regenerative medicine using the peptide derived from the domain

2008 - 2010 Cell transplantation for the treatment of spinal cord injury in rats-morphological study and search for humoral effective factors-

2007 - 2009 神経・筋変性疾患における細胞移植システムの構築と自己細胞移植治療法の開発

2005 - 2009 自己細胞移植による神経・筋肉変性疾患の根本的治療法の開発

2007 - 2008 The mechanism of transdifferentiation in bone marrow stromal cells

2004 - 2007 Neural induction of somatic stem cells / ES cells by VHL gene /peptide and application to regenerative medicine

2005 - 2006 The effects of transplantation of dopaminergic neuron induced from bone marrow stromal cells into amblyopia model through cerebrospinal fluid in rat

2005 - 2006 Bone marrow stromal cell transplantation as the treatment for glaucomatous optic neuropathy.

2005 - 2006 Regeneration of neurons and vessels using bone marrow cells and gene delivery

2005 - 2006 Promotion of brain-and spinal-cord regeneration by transplantation of somatic cells(bone marrow stromal cells and choroid plexus ependymal cells)-mechanisms of rescuing injured neural cells, and perspectives for clinical applications-

2005 - 2006 骨髄間質細胞からの神経・骨格筋幹細胞の効率町誘導と自己再生システムの開発

2005 - 2006 Specific induction of functional neurons and skeletal muscle cells from bone marrow stromal cells and their application for auto-cell transplantation therapy in neuro-and muscle degenerative diseases

2004 - 2006 骨髄間質細胞からの神経並びに筋細胞の選択的誘導とパーキンソン病・筋ジストロフィーへの自家移植治療法の開発

2004 - 2005 Transplantation of human bone marrow stromal cell-derived Schwann cell for contusive spinal cord injury of adult rats

2003 - 2004 ラット脊髄損傷モデルに対する骨髄間質細胞由来シュワン細胞移植の有用性の検討

2003 - 2004 表皮細胞を神経細胞に分化転換させる方法の開発-自己再生を目指して-

2003 - 2004 Establishment of adult rat-derived stem cells, and histological/functional reconstruction of spinal cord by auto- and allo-grafting of those stem cells

2003 - 2004 The reset and transdifferentiation of bone marrow stromal cells and developmental research for organ regeneration

2002 - 2004 The mechanism of the induction of differentiation of bone marrow stromal stem cells and its application

2004 - 合成蛋白質導入による骨髄間質細胞の選択的神経細胞誘導と神経変性疾患への応用

2002 - 2003 VHL遺伝子による神経幹細胞・ES細胞の神経分化メカニズムの解明とその応用

2003 - 骨髄間質細胞からの選択的な神経細胞誘導法の確立とパーキンソンモデルへの移植応用

2001 - 2002 神経-シュワン細胞間に形成されるタイトおよびギャップ結合の再生における役割

2002 - 骨髄間質細胞の神経系細胞への分化誘導並びに神経損傷・パーキンソンモデルへの応用

1999 - 2000 遺伝子導入シュワン細胞を用いた人工移植片開発による視神経再生

1998 - 2000 Optic nerve regeneration by usage of artificial Schwann cell graft

1998 - 1999 近視化初期における眼球形態形成及び神経回路網による制御機能の解析

1997 - 1998 培養シュワン細胞移植による損傷視神経の再生促進手段の開発

1996 - 1998 PERIPHERAL NERVE REGENERATION IN MAGNETIC STIMULATION

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Papers (207)：

Juntaro Koyama, Shinichi Yamashita, Yuya Kato, Kunihisa Nezu, Takuro Goto, Shinji Fujii, Yu Suzuki, Atsushi Nakayashiki, Yoshihide Kawasaki, Naoki Kawamorita, et al. Intravenously engrafted human multilineage-differentiating stress-enduring (Muse) cells rescue erectile function after rat cavernous nerve injury. BJU international. 2023
Yo Oguma, Nicola Alessio, Domenico Aprile, Mari Dezawa, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi. Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics. Cell Communication and Signaling. 2023. 21. 1
Kazuto Ueda, Yoshiaki Sato, Shinobu Shimizu, Toshihiko Suzuki, Atsuto Onoda, Ryosuke Miura, Shoji Go, Haruka Mimatsu, Yuma Kitase, Yuta Yamashita, et al. Systemic administration of clinical-grade multilineage-differentiating stress-enduring cells ameliorates hypoxic-ischemic brain injury in neonatal rats. Scientific reports. 2023. 13. 1. 14958-14958
Gen Li, Shohei Wakao, Masaaki Kitada, Mari Dezawa. Tumor suppressor let-7 acts as a key regulator for maintaining pluripotency gene expression in Muse cells. 2023
Toshihide Nagaoki, Gentaro Kumagai, Yohshiro Nitobe, Ayako Sasaki, Taku Fujita, Tatsuhiro Fukutoku, Kenya Saruta, Manami Tsukuda, Toru Asari, Kanichiro Wada, et al. Comparison of the Anti-Inflammatory Effects of Mouse Adipose- and Bone-Marrow-Derived Multilineage-Differentiating Stress-Enduring Cells in Acute-Phase Spinal Cord Injury. Journal of neurotrauma. 2023

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MISC (126)：

的場聖明, 矢西賢次, 庄司圭祐, 堀友亮, 川俣博文, 後藤大輝, 木谷友哉, 出澤真理. 血管再生医療の現状と課題. 脈管学. 2021. 61. Suppl. S137-S137
DEZAWA Mari. Muse細胞による消化器疾患治療. 消化器疾患の最新医療. 2018. 49. 1-6
伊関雅裕, 水間正道, 深瀬正彦, 小野智之, 志村充宏, 鈴木ゆき恵, 伊勢一郎, 石田晶玄, 工藤克昌, 林洋毅, et al. 肝再生におけるMuse細胞移植の可能性. 日本外科学会定期学術集会抄録集. 2018. 118回. 1249-1249
DEZAWA Mari. An expect for paradigm shift of medical treatment by endogenous reparative Muse cells. ANTI-AGING MEDICINE. 2018. 14. 2. 226-233
伊関雅裕, 若尾昌平, 串田良祐, 水間正道, 深瀬正彦, 林洋毅, 元井冬彦, 出澤真理, 海野倫明. 臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究マウス肝障害モデルを用いたMuse細胞移植療法の検討. 日本消化器外科学会総会. 2017. 72回. WS14-11

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Patents (3)：

脳梗塞治療のための多能性幹細胞
心筋梗塞の修復再生を誘導する多能性幹細胞
生体組織から単離できる多能性幹細胞

Books (10)：

Muse cells; Endogenous Reparative Pluripotent Stem Cells. Advances in Experimental Medicine and Biology
Springer 2018
Muse cells, non-tumorigenic endogenous pluripotent stem cells, as a source for generating functional melanocytes
Springer International Publishing 2017
Muse cells
Springer Nature 2017
Vision
Taylor and Francis Publishing 2010
Regeneration (synopsis)
Springer-Verlag 2009

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Lectures and oral presentations (151)：

未来の医療を変えるMuse細胞の発見と秘話:チャンスはどのように訪れるのか
(2023)
Muse細胞のもたらす医療イノベーション
(2023)
幹細胞・病的細胞を量子科学の視点から観る
(2023)
Muse細胞がリードする医療変革と健康長寿社会の実現
(2023)
Muse細胞がリードする未来の医療と健康長寿社会の実現
(第26回リウマチフォーラム 2023)

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Education (1)：

1991 - 1995 Graduate School of Medicine, Chiba University Ph.D

Professional career (1)：

医学博士 (千葉大学)

Work history (6)：

2019/11 - 現在 Dokkyo Medical University School of Medicine Specially Appointed Professor
2008/04 - 現在 Tohoku University Graduate School of Medicine Department of Stem Cell Biology and Histology Professor and Chair
2003/01 - 2008/03 Kyoto University Graduate School of Medicine Department of Anatomy and Neurobiology Associate Professor
2000/04 - 2002/12 Yokohama City University School of Medicine Department of Anatomy Assistant Professor
1997/04 - 2000/03 School of Medicine Chiba University Department of Ophthalmology Research Associate

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Committee career (16)：

2023 - 現在日本抗加齢医学会評議員
2021 - 現在日本再生医療学会理事長補佐
2016 - 現在青森県教育委員会SSH(スーパーサイエンスハイスクール) 運営指導委員
2016 - 現在東洋紡バイオテクノロジー研究財団理事
2015 - 現在先進医薬研究振興財団選考委員

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Awards (6)：

2018 - National Academy of Inventors(NAI) Fellow
2015 - the 8th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) Everfront Award
2011 - the Minister of Education, Culture, Sports, Science and Technology Prizes for Science and Technology
2003 - Japanese Society of Microscopy Incitement Award
1999 - Japanese Association of Anatomists Incitement Award

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Association Membership(s) (6)：

日本抗加齢医学会 , 量子生命科学会 , Pan Pacific Symposium on Stem Cells and Cancer Research , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , THE JAPANESE SOCIETY OF MICROSCOPY , THE JAPANESE ASSOCIATION OF ANATOMISTS

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