Chikuma Shunsuke

チクマシュンスケ | Chikuma Shunsuke

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.maroon.dti.ne.jp/schikuma/

Research field (1)： Immunology

Research theme for competitive and other funds (12)：

2022 - 2025 内在性レトロウイルス抑制因子による、がん免疫寛容機構の基盤研究
2022 - 2024 アバタセプト抵抗性「しつこい」記憶T細胞を除去する方法の探索
2021 - 2023 自己免疫疾患の発症・非発症を規定する特異点の検出
2019 - 2022 Mechanisms of long-term survival of self-reactive helper T cells
2019 - 2021 クロマチン抑制因子の破綻によるネオセルフ生成

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Papers (51)：

By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma. Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition. iScience. 2024. 27. 1. 108646-108646
Ran Nakamichi, Akihito Hishikawa, Shunsuke Chikuma, Akihiko Yoshimura, Takashi Sasaki, Akinori Hashiguchi, Takaya Abe, Tomoko Tokuhara, Norifumi Yoshimoto, Erina Sugita Nishimura, et al. DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation. Cell reports. 2023. 42. 5. 112427-112427
Kazuhide Miyamoto, Hodaka Hayabuchi, Yukiko Tokifuji, Makoto Ando, Nobuyuki Onishi, Tadashi Okamuara, Akihiko Yoshimura, Shunsuke Chikuma. A Protein Kinase D Inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by Anti-PD-1. International immunology. 2022. 34. 12. 609-619
Shunsuke Chikuma, Soichiro Yamanaka, So Nakagawa, Mahoko Takahashi Ueda, Hodaka Hayabuchi, Yukiko Tokifuji, Masashi Kanayama, Tadashi Okamura, Hisashi Arase, Akihiko Yoshimura. TRIM28 expression on dendritic cells prevents excessive T cell priming by silencing endogenous retrovirus. Journal of Immunology. 2021. 206. 7. 1529-1539
Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Nishimasu H, et al. The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells. Cancer Research. 2020. 80. 3. 471-483

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MISC (10)：

Shunsuke Chikuma, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura. Pathogenesis of autoreactive Th17 cells is driven by homeostatic cytokines stimulated by commensal microbiota. CYTOKINE. 2017. 100. 29-30
T. Kondo, R. Morita, Y. Kassai, T. Sekiya, S. Chikuma, Y. Gotou, M. Kanamori, T. Miyazaki, M. Kubo, A. Yoshimura. Reprogramming of T cells from effector to stem cell memory by Notch signaling. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 986-986
Zhang Baihao, Chikuma Shunsuke, Hori Shohei, Fagarasan Sidonia, Honjo Tasuku. Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model. Proceedings of the National Academy of Sciences of the United States of America. 2016. 113. 30. 8490-8495
Junzo Hamanishi, Masaki Mandai, Takafumi Ikeda, Manabu Minami, Atsushi Kawaguchi, Masashi Kanai, Yukiko Mori, Shigemi Matsumoto, Toshinori Murayama, Shunsuke Chikuma, et al. Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer. American Society of Clinical Oncology. 2014. 32. 15
Yuxiang Rui, Tasuku Honjo, Shunsuke Chikuma. Programmed cell death 1 inhibits inflammatory helper T-cell deèelopment through controlling the innate immune response. Proceedings of the National Academy of Sciences of the United States of America. 2013. 110. 40. 16073-16078

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Professional career (1)：

博士(医学) (北海道大学)

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