Rchr
J-GLOBAL ID：201401032507375208
Update date: Feb. 06, 2024
Yokoyama Akihiko
ヨコヤマ アキヒコ | Yokoyama Akihiko
Affiliation and department：
Job title：
Unit Leader
Research field (3)：
Molecular biology
, Hematology and oncology
, Tumor biology
Research keywords (3)：
Transcription
, Childhood cancer
, Leukemia
Research theme for competitive and other funds (8)：
- 2022 - 2027 Development of novel therapies for ENL-mutated Wilms tumor
- 2022 - 2025 Mechanisms of AF10-rearranged leukemia
- 2019 - 2022 Mechanisms of MLL-rearranged leukemia
- 2016 - 2019 Development of novel therapy for MLL-rearranged leukemia
- 2013 - 2015 AEP複合体による転写サイクルの制御メカニズム
- 2013 - 2015 Mechanisms of niche-independent self-renewal by MLL fusion proteins
- 2011 - 2015 The role of the AEP complex in MLL fusion-dependent leukemogenesis
- 2010 - 2015 Mechanisms underlying epigenome regulation by chromatin modifications during stem cell differentiation
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Papers (52)：
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Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, et al. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. Nature communications. 2023. 14. 1. 8372-8372
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Yu Chen, Tatsuki Yamamoto, Yura Takahashi, Tomoka Moro, Tomoko Tajima, Yukiko Sakaguchi, Naoaki Sakata, Akihiko Yokoyama, Susumu Hijioka, Akane Sada, et al. Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors. Cell death & disease. 2023. 14. 9. 597-597
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Yosuke Komata, Akinori Kanai, Takahiro Maeda, Toshiya Inaba, Akihiko Yokoyama. MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins. Nature communications. 2023. 14. 1. 1979-1979
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Dustin C Becht, Brianna J Klein, Akinori Kanai, Suk Min Jang, Khan L Cox, Bing-Rui Zhou, Sabrina K Phanor, Yi Zhang, Ruo-Wen Chen, Christopher C Ebmeier, et al. MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain. Nature communications. 2023. 14. 1. 697-697
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Akihiko Yokoyama. Role of the MOZ/MLL-mediated transcriptional activation system for self-renewal in normal hematopoiesis and leukemogenesis. The FEBS Journal. 2022. 289. 24. 7987-8002
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MISC (6)：
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Akihiko Yokoyama, Hiroshi Okuda. The Molecular Mechanism of Transcriptional Activation By MLL-AEP Fusion Proteins. BLOOD. 2015. 126. 23
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Akihiko Yokoyama, Francesca Ficara, Issay Kitabayashi, Michael L. Cleary. The Roles of MLL Holocomplex in Embryogenesis, Hematopoiesis and Tumor Suppression. BLOOD. 2009. 114. 22. 1159-1159
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A Yokoyama, T Somervaille, ML Cleary. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. BLOOD. 2005. 106. 11. 196A-196A
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A Yokoyama, Z Wang, J Wysocka, M Sanyal, DJ Aufiero, Kitabayashi, I, W Herr, ML Cleary. Leukemia proto-oncoprotein MLL forms a SET1 like complex with menin to regulate Hox gene expression. BLOOD. 2004. 104. 11. 699A-699A
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KITABAYASHI Issay, AIKAWA Yukiko, YOKOYAMA Akihiko, SUZUKI Mitsuhiro, MOROHOSHI Fumiko, OHKI Misao. Roles of histon acetylaces and deacetylases in AML1-depedent cell differentiation and AML1-MTG8-mediated leukemogenesis. 1998. 21. 203-203
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Education (3)：
- 1997 - 2001 Tokyo Medical and Dental University
- 1995 - 1997 Hokkaido University
- 1991 - 1995 Hokkaido University School of Science Chemistry
Work history (6)：
Committee career (1)：
Awards (2)：
- 2005 - Special fellowship award of Leukemia and Lymphoma society
- 2003 - American Society of Hematology Scholar Award
Association Membership(s) (3)：
日本分子生物学会
, 日本血液学会
, 日本癌学会
