Takano Hirohisa

Affiliation and department：
Job title： Professor

Research field (1)： Environmental effects of chemicals

Research theme for competitive and other funds (34)：

2023 - 2026 一般環境中のPM2.5による糖尿病発症、悪化メカニズムの解明
2023 - 2026 Composition, particle size and health effects of microplastics with focus on intestinal environment and diabetes
2023 - 2025 マイクロプラスチックの経口曝露によるアレルギーの悪化とメカニズムの解明
2021 - 2025 花粉由来タンパク質の黄砂表面における化学的変質と花粉症症状増悪に対する影響
2021 - 2024 Development of a model for estimating health/economic damages from pandemic and the effect of public-immunity resilience program

2019 - 2024 環境中微粒子の体内、細胞内動態、生体・免疫応答機序の解明と外因的、内因的健康影響決定要因、分子の同定

2020 - 2023 サイクロン装置で採取した公共的屋内空間中PM2.5の生体影響と影響決定成分の同定

2016 - 2021 Comprehensive and systematic study for control/eradication of allergic diseases via environmental and medical approaches

2017 - 2020 Secondary Formation of Toxic Oxy-PAHs in the Atmosphere Catalyzed by Asian Dust: Cross-Border Transport and Health Effects

2015 - 2018 Physiological effects of brominated flame retardants on allergic disease, study for prevention

2015 - 2018 Integrated evaluation of PM2.5 affected by transboundary haze in Malaysia from the viewpoints of characteristics, emission source and health impact

2014 - 2016 Effect of airborne fine particles for allergic rhinitis

2013 - 2016 In-situ Real-Time Monitoring of Volatile Organic Compound Exposure for Patients with Multiple Chemical Sensitivity

2010 - 2014 Studies on the aggravation mechanism of allergy by the environmental pollutants with emphasis on the cell-to-cell interaction and the intracellular signal network

2008 - 2014 Impacts of Aerosols in East Asia on Plants and Human Health-Research Generalization

2011 - 2013 Environmental epidemiologic investigation of the influence of Asian sand on allergy symptoms

2010 - 2012 Fundamental study on pathologic conditions of multiple chemical sensitivity

2008 - 2012 EVALUATION OF BIOLOGICAL EFFECTS OF AEROSOL

2009 - 2011 Mechanism of nano-particle translocation at the air-bloodbarrier and its effects on health

2008 - 2011 Sensor proteins and cellular protection factors for environmental electrophiles

2008 - 2009 環境化学物質による脂肪肝の増悪とその機構解明に関する研究

2006 - 2008 Naphthalens that covalently bind to macromolecules contaminated in the atmosphere in southern California

2006 - 2008 Studies on the evaluation and mechanisms of health effects of nanomaterials with special emphasis on the sensitivity

2006 - 2007 大気中浮遊粒子状物質が脂肪肝と白内障に及ぼす影響と機構の解明に関する研究

2006 - 2007 ディーゼル排出微粒子中に存在する未知の親電子性物質の新規探索法の開発

2005 - 2007 Accumulation of suspended particulate matters (SPM) in the lung of dogs: toxicity of the SPM on the lung tissues

2004 - 2006 Effects of Asian sand dust on lung toxicity, allergy, oxidative DNA damages, and reproductive function

2003 - 2005 Biological effect of quinoid compounds causing oxidative stress contaminated in ambient particulate matter

2003 - 2004 Production of Oxidative Stress-Related ProteinChip and Its Evaluation on Biomarker for Common Disease

2003 - 2004 Effects of diesel exhaust particles on diabetes mellitus and its complications

2002 - 2003 EVELOPMENT OF MICROASSEY SYSTEM TO AIM AT ENVIRONMENTAL MONITORING.

2001 - 2002 Effects of diesel exhaust particles on cardiorespiratory health

1996 - 1997 Role of 1ymphocytes in airway inflammation and hyperresponsiveness induced by diesel exhaust particles.

1996 - 1997 Experimental Study on a new mechanism of allergic asthma-like-pathogenesis.

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Papers (388)：

Wahida Musarrat Anita, Athicha Uttajug, Xerxes Tesoro Seposo, Kengo Sudo, Makiko Nakata, Toshihiko Takemura, Hirohisa Takano, Taku Fujiwara, Kayo Ueda. Interplay of Climate Change and Air Pollution- Projection of the under-5 mortality attributable to ambient particulate matter (PM2.5) in South Asia. Environmental Research. 2024
Yuka Hasegawa, Takuro Okamura, Hanako Nakajima, Nobuko Kitagawa, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, et al. Metabolic outcomes and changes in innate immunity induced by diesel exhaust particles airway exposure and high-fat high-sucrose diet. Life sciences. 2023. 326. 121794-121794
A Honda, KI Inoue, M Higashihara, T Ichinose, K Ueda, H Takano. Differential Pattern of Cell Death and ROS Production in Human Airway Epithelial Cells Exposed to Quinones Combined with Heated-PM2.5 and/or Asian Sand Dust. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023. 24. 13. 10544
高野裕久, 佐川友哉, 本田晶子. 環境中微粒子の体内,細胞内動態,生体・免疫応答機序の解明と外因的,内因的健康影響決定要因,分子の同定. 生化学. 2023. 95. 2. 169-176
Arthit Phosri, Kayo Ueda, Xerxes Seposo, Akiko Honda, Hirohisa Takano. Effect modification by temperature on the association between O3 and emergency ambulance dispatches in Japan: A multi-city study. The Science of the total environment. 2023. 861. 160725-160725

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MISC (247)：

本田晶子, 高野裕久. パーソナルケア製品成分の健康影響. 大気環境学会誌. 2024. 59. 1. A47-A49
本田晶子, 高野裕久. パーソナルケア製品成分の健康影響. 大気環境学会年会講演要旨集. 2023. 64回. 74-75
石川良賀, 檜垣有哉, 渡邊ヒカリ, 本田晶子, 市瀬孝道, 高野裕久. 地下鉄で発生する粒子状物質の主成分である酸化鉄微粒子の生体影響. The Journal of Toxicological Sciences. 2023. 48. Suppl. S83-S83
奥川友裕, 佐川友哉, 石川良賀, 宮坂奈津子, 長尾慧, 本田晶子, 高野裕久. 酸化チタンナノ粒子による肺炎症応答におけるネクロトーシスの役割. The Journal of Toxicological Sciences. 2023. 48. Suppl. S116-S117
西條優斗, 長谷川由佳, 岡村拓郎, 中島華子, 北川暢子, 間嶋紗織, 岡田博史, 千丸貴史, 牛込恵美, 中西尚子, et al. マウスにおけるマイクロプラスチック経口投与による代謝障害の検討. 糖尿病. 2023. 66. Suppl.1. S-154

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Patents (1)：

呼吸機能低下抑制用組成物

Books (2)：

Urinary trypsin inhibitor, an alternative therapeutic option for inflammatory disorders. Inflammatory Diseases/Book 3.
INTECH OPEN ACCESS PUBLISHER 2010
黄砂変質の影響:動物実験「黄砂」
古今書院 2009

Lectures and oral presentations (45)：

Identification of the Factors Responsible for the Health Effects of Atmospheric Fine Particles by Cyclone Collection Method and Exposure Experiments.
(IAC2018 CYCLEX 2018)
Cyclone collection of fine and coarse particles followed by exposure experiments.
(IGAC 2018)
Effect of streamer plasma irradiation on ambient PM2.5-induced pro-inflammatory responses in human bronchial epithelial cells.
(IndoorAir2018 2018)
Health effect of air pollution in Thailand: Recent research development and challenges.
(ISEE-AC 2018)
夏季の高気温が救急搬送数に与える影響:年齢別の検討
(第88回日本衛生学会学術総会 2018)

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