Nakae Dai

ナカエダイ | Nakae Dai

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/90207712.ja.html

Research field (3)： Hygiene and public health (non-laboratory) , Nutrition and health science , Experimental pathology

Research keywords (24)： food factor , toxicologic pathology , Preventive Medicine , Animal Preventive Medicine , safety asessment , risk analysis , preneoplastic lesion , gene mutation , oxidative stress , choine-deficient, methionine-lowered, L-amino acid-defined diet , epigenetic carcinogenesis , species difference , gpt delta transgenic animal , endogenous carcinogenesis , 8-oxoguanine , heterocyclicamine , nitroso compound , environmental carcinogen , genetically modified animal , diethylnitrosamine , chemical caricnogenesis , environmental factor , carcinogen , toxicology

Research theme for competitive and other funds (5)：

2005 - 2009 がん研究の資材有効保存と利用に関する研究
2004 - 2005 Study on the Mechanisms Underlying Endogenous Hepatocarcinogenesis Induced Only by the Manipulation of Food Composition
1996 - 1999 Risk Assessment of Carcinogenesis due to Environmental Agents
1996 - 1999 Basic Research on the Development and Progression of Pancreatic Duct Adenocarcinoma
1992 - 1992 ラット肝における酸化性DNA障害依存性発癌機構と肝細胞壊死

Papers (201)：

Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae. Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet. Journal of Toxicologic Pathology. 2023. 36. 1. 1-10
Kinuko Uno, Katsuhiro Miyajima, Shuji Ogawa, Noriko Suzuki-Kemuriyama, Dai Nakae. Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet. JOURNAL OF TOXICOLOGIC PATHOLOGY. 2023. 36. 1. 1-10
Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae. Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet. (Lipids in Health and Disease, (2020), 19, 1, (251), 10.1186/s12944-020-01423-3). Lipids in Health and Disease. 2022. 21. 1
Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, et al. Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats. Particle and Fibre Toxicology. 2022. 19. 1
Kinuko Uno, Katsuhiro Miyajima, Marika Toma, Noriko Suzuki-Kemuriyama, Dai Nakae. CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet. Journal of toxicologic pathology. 2022. 35. 2. 149-157

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MISC (43)：

Noriko Suzuki-Kemuriyama, Akari Abe, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae. A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet (vol 19, 251, 2020). LIPIDS IN HEALTH AND DISEASE. 2022. 21. 1
Mandai K, Miyajima K, Kitamura S, Yamaguchi A, Uno K, Kuroki F, Nishida M, Shirasaka K, Tsustui T, Muro Y, et al. Effect of high fat diet on liver in db/db and KK-Ay mice. 2021. 46. Suppl. S109-S110
Takayuki Anzai, Masamichi Kaminishi, Keizo Sato, Laura Kaufman, Hijiri Iwata, Dai Nakae. Responses to the standard for exchange of nonclinical data (SEND) in non-US countries. Journal of Toxicologic Pathology. 2015. 28. 2. 57-64
Robert A. Floyd, Yashige Kotake, Rheal A. Towner, We-Xing Guo, Dai Nakae, Yoichi Konishi. Nitric oxide and cancer development. Journal of Toxicologic Pathology. 2007. 20. 2. 77-92
D. Nakae, R. A. Floyd. Antioxidant and signal-normalizing properties of phenyl N-tert-butyl nitrone and its derivatives in chemoprevention of hepatocellular carcinoma. CHEMICO-BIOLOGICAL INTERACTIONS. 2006. 161. 3. 196-196

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Professional career (1)：

D.M.Sc. (Nara Medical University)

Work history (2)：

2022/04 - 現在 Teikyo Heisei University Animal Medical Course, Department of Medical Sports, Faculty of Health Care and Medical Sports Professor
2015/04 - 2022/03 Tokyo University of Agriculture Laboratory of Food Safety Assessment Science, Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences Professor

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