Motegi Akira

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (5)：

2017 - 2022 English title
2013 - 2017 Analysis of DNA-damage-tolerance mechanisms that facilitate restart of stalled DNA replication
2010 - 2012 Analysis of regulatory mechanisms of DNA repair by ubiquitination
2008 - 2010 Analysis of DNA damage response using gene-disrupted DT40 clones.
2007 - 2008 Ubiquitin-dependent regulation of DNA replication arrest

Papers (26)：

Takafumi Koyauchi, Hiroyuki Niida, Akira Motegi, Satoshi Sakai, Chiharu Uchida, Tatsuya Ohhata, Kenta Iijima, Akihiko Yokoyama, Takafumi Suda, Masatoshi Kitagawa. Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair. Biochimica et biophysica acta. Molecular cell research. 2022. 1869. 11. 119332-119332
Koji Nishimoto, Hiroyuki Niida, Chiharu Uchida, Tatsuya Ohhata, Kyoko Kitagawa, Akira Motegi, Takafumi Suda, Masatoshi Kitagawa. HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation. Molecular cancer research : MCR. 2020. 18. 9. 1367-1378
Motegi A, Masutani M, Yoshioka KI, Bessho T. Aberrations in DNA repair pathways in cancer and therapeutic significances. Seminars in cancer biology. 2019
Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, et al. Erratum: Author Correction: Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair (Nature communications (2017) 8 (16102)). Nature communications. 2018. 9. 16214-16214
Ayako L. Mochizuki, Ami Katanaya, Eri Hayashi, Mihoko Hosokawa, Emiko Moribe, Akira Motegi, Masamichi Ishiai, Minoru Takata, Gen Kondoh, Hitomi Watanabe, et al. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. MOLECULAR AND CELLULAR BIOLOGY. 2017. 37. 23

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MISC (6)：

茂木章, Wang Junhui, 藤森浩彰, 三木義男, 益谷美都子. NAD+-poly(ADP-ribose)代謝を標的とした創薬研究の新展開基礎から臨床応用まで PARP-1及びPARGはDNA二本鎖切断末端のリゼクション制御によりゲノム安定性を促進する. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4W6-4]
Wang Junhui, 茂木章, 藤森浩彰, 三木義男, 益谷美都子. PARP-1とPARGは放射線応答において53BP1の制御に関与する(PARP-1 and PARG are both required for the regulation of 53BP1 after IR). 日本癌学会総会記事. 2014. 73回. J-3008
Wang Junhui, 茂木章, 藤森浩彰, 三木義男, 益谷美都子. PARP-1は5'-及び3'-ブロック2本鎖切断端からのCtIPが関与する過剰なエンドリセクションを抑制する(PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP). 日本癌学会総会記事. 2013. 72回. 116-116
足立淳, 鳴海良平, 佐野聖三, 久家貴寿, 白水崇, 松本雅記, 中山敬一, 茂木章, 井倉毅, 高田穣, et al. 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」. 第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月. 2010
茂木章, 村川泰裕, 武田俊一. ユビキチン化によるDNA修復の制御機構. 実験医学. 2008. 26. 2

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