Rchr

J-GLOBAL ID：201401043118310208 Update date: Mar. 27, 2023

OHASHI Akiko

オオハシアキコ | OHASHI Akiko

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Pharmacology

Research keywords (3)：モノアミン , 輸送体 , テトラヒドロビオプテリン

Research theme for competitive and other funds (3)：

2017 - 2019 肥満症および糖尿病の治療に向けた新規標的分子の探索
2016 - 2017 セピアプテリンの脳内モノアミンレベル上昇効果の作用機序の解明
歯周病を含む糖尿病合併症に対する新規治療薬の開発

Papers (21)：

Naoya Nishitani, Yu Ohmura, Kazuki Nagayasu, Norihiro Shibui, Shuji Kaneko, Akiko Ohashi, Takayuki Yoshida, Akihiro Yamanaka, Mitsuhiro Yoshioka. CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice. Brain Research. 2019. 1719. 243-252
Forced expression of mouse progerin attenuates the osteoblast differentiation interrupting β-catenin signal pathway in vitro. Cell Tissue Res. 2019. 375. 655-664
Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa. Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess. MOLECULAR AND CELLULAR BIOCHEMISTRY. 2017. 435. 1-2. 97-108
Naoya Tsukune, Masako Naito, Tatsuya Kubota, Yasumasa Ozawa, Mayu Nagao, Akiko Ohashi, Shuichi Sato, Tomihisa Takahashi. Lamin A overexpression promotes osteoblast differentiation and calcification in the MC3T3-E1 preosteoblastic cell line. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017. 488. 4. 664-670
Oguri Y, Fujita Y, Abudukadier A, Ohashi A, Goto T, Furuya F, Obara A, Fukushima T, Matsuo N, Kim M, et al. Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism. JCI Insight. 2017. 2. 9. doi: 10.1172/jci.insight.91981

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Lectures and oral presentations (17)：

モノアミン産生細胞におけるテトラヒドロビオプテリンの2つの効果
(日本ビタミン学会第71回大会 2019)
テトラヒドロビオプテリンのプロドラッグ(セピアプテリン)投与による脳内セロトニン生合成活性の促進
(第124回日本解剖学会総会・全国学術集会 2019)
Tetrahydrobiopterin Is Required for Brown Adipose Tissue Development and Differentiation
(The 11th Scientific Meeting of the Asian Association for the Study of Diabetes 2019)
Tetrahydrobiopterin Regulates Developmental Differentiation of Brown Adipose Tissue
(79th American Diabetes Association 2019)
モノアミン生合成を調節するテトラヒドロビオプテリンの細胞膜輸送
(日本ビタミン学会第70回大会 2018)

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