2019 - 2023 Elucidation of the functional mechanisms associated with structural dynamics of antibodies by integration of cutting-edge measurement approaches
2020 - 2022 糖鎖とタンパク質が織りなす抗体のアロステリックネットワークの探査
2018 - 2020 抗体とFc受容体の新規相互作用様式の解明と抗体工学への展開
2015 - 2019 Elucidation of the proteasome formation mechanisms through multilateral structural biology approach toward drug discovery
2017 - 2019 抗体の分子認識を契機とする補体系の活性化を活写する
2013 - 2018 Exploration of micro-macro relationships in dynamic ordering of biomolecular systems and their underlying design principles
2013 - 2016 抗原抗体相互作用の動的構造解析を基盤とした高機能抗体の設計
2011 - 2013 ヒト主要組織適合複合体の揺らぎと細胞の抗原提示能に関する研究
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Papers (65):
Saeko Yanaka, Atsuji Kodama, Shigetaka Nishiguchi, Rina Hiramine, Jiana Shen, Pornthip Boonsri, Duckyong Sung, Yukiko Isono, Hirokazu Yagi, Yohei Miyanoiri, et al. Identification of potential C1-binding sites in the immunoglobulin CL domains. International Immunology. 2024
Saeko Yanaka, Hiroki Watanabe, Rina Yogo, Mesayamas Kongsema, Sachiko Kondo, Hirokazu Yagi, Takayuki Uchihashi, Koichi Kato. Quantitative Analysis of Therapeutic Antibody Interactions with Fcγ Receptors Using High-Speed Atomic Force Microscopy. Biological & pharmaceutical bulletin. 2024. 47. 1. 334-338
Methanee Hiranyakorn, Maho Yagi-Utsumi, Saeko Yanaka, Naoya Ohtsuka, Norie Momiyama, Tadashi Satoh, Koichi Kato. Mutational and environmental effects on the dynamic conformational distributions of Lys48-linked ubiquitin chains. International Journal of Molecular Sciences. 2023. 24. 7. 6075
Saeko Yanaka, Rina Yogo, Hirokazu Yagi, Masayoshi Onitsuka, Natsumi Wakaizumi, Yuki Yamaguchi, Susumu Uchiyama, Koichi Kato. Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins. Frontiers in Immunology. 2023. 14
Saeko Yanaka, Maho Yagi-Utsumi, Koichi Kato, Kunihiro Kuwajima. The B Domain of Protein A Retains Residual Structures in 6 M Guanidinium Chloride as Revealed by Hydrogen/Deuterium-Exchange NMR Spectroscopy. Protein science : a publication of the Protein Society. 2023. e4569
Experimental approaches of NMR spectroscopy : methodology and application to life science and materials science
Springer 2018 ISBN:9789811059650
Lectures and oral presentations (54):
Analysis of antibody interaction and function in serum
(日本薬学会年会要旨集(Web) 2021)
Development of method for studying dynamical structures and interactions of antibodies and its applications to antibody engineering
(日本薬学会年会要旨集(Web) 2021)
High-precision structural analysis of antibody molecules by SEC-iCM-SANS
(量子ビームサイエンスフェスタ(Web) 2021)