Watanabe Mizuki

ワタナベミズキ | Watanabe Mizuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www.pharm.hokudai.ac.jp/yuuki/index.html

Research field (2)： Chemical biology , Pharmaceuticals - chemistry and drug development

Research keywords (10)： foldamer , peptidomimetics , ケミカルバイオロジー , 医薬分子設計 , 配座制御 , 有機合成化学 , 化合物ライブラリー , 脂質代謝 , 医薬品化学 , 構造活性相関

Research theme for competitive and other funds (7)：

2022 - 2025 Development Research on Peptide Foldamers Based on Conformationally Restricted Amino Acids
2019 - 2023 三次元構造制御を鍵とした分子設計に基づく機能性ペプチドの開発
2019 - 2023 高分子間相互作用を制御する合成機能分子を論理的・効率的に創出する方法論の確立
2017 - 2019 Development of a new foldamer as a mimetic of alfa-helix
2014 - 2017 Analysis of regulation of lipid metabolism by vitamin D metabolite

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Papers (43)：

Noriko Omura, Akihiro Taguchi, Tomoki Kuwahara, Keisuke Hamada, Mizuki Watanabe, Masanori Nakakuki, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Toshifumi Nomura, et al. Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity. ACS Medicinal Chemistry Letters. 2023
Mizuki Watanabe. Development of aliphatic homo-δ-peptide folders based on rational design. 2023. 55. 9. 69-72
Makoto Nagata, Mizuki Watanabe, Ryohei Doi, Mai Uemura, Nanase Ochiai, Wataru Ichinose, Koichi Fujiwara, Yoshihiro Sato, Tomoshi Kameda, Koh Takeuchi, et al. Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane. Organic & Biomolecular Chemistry. 2023. 21. 5. 970-980
Masaki Gomi, Yu Sakurai, Minami Sato, Hiroki Tanaka, Yumi Miyatake, Koichi Fujiwara, Mizuki Watanabe, Satoshi Shuto, Yuta Nakai, Kota Tange, et al. Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine-Loaded Lipid Nanoparticles. Advanced Healthcare Materials. 2022. 2202528-2202528
Shota Arai, Koichi Fujiwara, Masahiro Kojima, Haruka Aoki-Saito, Masakiyo Yatomi, Tsugumichi Saito, Yasuhiko Koga, Hayato Fukuda, Mizuki Watanabe, Shigeki Matsunaga, et al. Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents. The Journal of Organic Chemistry. 2022. 87. 15. 10501-10508

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MISC (31)：

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Patents (2)：

Books (1)：

Lectures and oral presentations (11)：

シクロプロパン骨格を有するSTAT3阻害剤の創出研究
(日本薬学会第143年会一般シンポジウム「JAK-STATサイトカインシグナル伝達系ーその発見から臨床現場へー」 2023)
“カタチ”を意識した分子設計に基づく創薬化学研究
(静岡大学総合科学技術研究科有用物質合成研究会 2023)
シクロプロパンによる配座制御を基軸としたペプチドフォルダマーの開発
(日本薬学会第142年会一般シンポジウム「フォルダマーの魅力 -構造多様性が拓く未来-」 2022)
シクロプロパンδ-アミノ酸を基盤としたヘリカルフォルダマーの開発
(日本薬学会第140年会一般シンポジウム「フォルダマーの魅力ーペプチド創薬のパラダイムシフトー」 2020)
配座制御による環状ペプチドの膜透過性の向上
(第14回トランスポーター研究会 2019)

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Education (3)：

Professional career (1)：

Work history (6)：

2021 - 現在 Hokkaido University Faculty of Pharmaceutical Sciences Associate Professor
2015 - 2021 Hokkaido University Faculty of Pharmaceutical Sciences Lecturer
2014 - 2015 Kyoto University Institute for Chemical Research Assistant Professor
2011 - 2014 Kyoto University Institute for Integrated Cell-Material Sciences Research Associate
2009 - 2011 Northwestern University Department of Chemistry Postdoctoral fellow

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Committee career (5)：

Awards (5)：

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