Takahashi Yuki

Affiliation and department：

Research field (1)： Biomedical engineering

Research keywords (1)： Biopharmaceutics, Drug delivery system, Gene therapy, Extracellular vesicle, Exosome

Research theme for competitive and other funds (17)：

2021 - 2024 樹状細胞由来細胞外小胞の免疫機能の最大化並びに動態制御に基づくワクチン療法開発
2020 - 2024 天然ステルスエキソソームの解析とデリバリーキャリア開発への応用
2020 - 2022 Development of tissue-cell two-step targeting method using cells producing siRNA-loaded exosomes.
2018 - 2021 Development of in vivo gene therapy using exosomes loading immunomodulatory molecules
2017 - 2019 Exploration of extracellular vesicles with long blood retention time and evaluateion of its physiological function

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Papers (135)：

Wakana Oda, Keisuke Umemura, Koichi Ito, Yusuke Kawamoto, Yuki Takahashi, Yoshinobu Takakura. Development of potent unmethylated CpG DNA hydrogel by introducing i-motifs into long single-stranded DNA. International Journal of Pharmaceutics. 2023. 123438-123438
Aki Yamamoto, Mihiro Toba, Yuki Takahashi, Yoshinobu Takakura. Pharmacokinetic Approach for the Elucidation of Elevated Plasma Small Extracellular Vesicle (sEV) Concentration in Cancer. Journal of pharmaceutical sciences. 2023. 112. 7. 1967-1974
Yusuke Kawamoto, You Wu, Yuki Takahashi, Yoshinobu Takakura. Development of Nucleic Acid Medicines Based on Chemical Technology. Advanced Drug Delivery Reviews. 2023. 114872-114872
Yuya Mizukami, Takuma Yamaguchi, Miki Shiono, Yuki Takahashi, Kazunori Shimizu, Satoshi Konishi, Yoshinobu Takakura, Makiya Nishikawa. Drug-preloadable methacrylated gelatin microspheres fabricated using an aqueous two-phase system. European Polymer Journal. 2022. 181. 111671-111671
Yuki Kobayashi, Shimpei Kitamura, Yuki Takahashi, Yoshinobu Takakura. Development of Enzymatic Depletion Methods for Preparation of Small Extracellular Vesicles with Long Blood-Circulation Half-Life. Pharmaceutical Research. 2022. 40. 4. 855-861

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MISC (24)：

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Patents (1)：

Books (13)：

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Lectures and oral presentations (9)：

細胞外小胞の動態解析に基づく疾患治療法の開発
(第6回日本細胞外小胞学会 2019)
Pharmacokinetics of Exosomes Evaluated by Using Exosome Labeling Methods
(大阪府立大学研究推進機構第31 回ケミカルバイオロジー研究所セミナー 2019)
3次元構造化による免疫細胞への核酸デリバリー
(第34回日本DDS学会 2018)
細胞外小胞エキソソームを基盤とした疾患治療法の開発
(第11回次世代を担う若手医療薬科学シンポジウム 2017)
核酸医薬のDDSへの応用を目的とした体内動態制御型核酸搭載exosomeの開発
(第31回日本DDS学会学術集会 2015)

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Work history (3)：

Awards (2)：

Association Membership(s) (1)：

日本細胞外小胞学会

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