YASUSHI SHINTANI

シンタニヤスシ | YASUSHI SHINTANI

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/90572983.ja.html

Research field (2)： Respiratory surgery , Cardiovascular surgery

Research keywords (13)：抗癌剤耐性 , 癌幹細胞 , 上皮間葉移行 , TGF , 癌微小環境 , 腫瘍間質 , TGF-b , 肺癌 , 癌間連線維芽細胞 , 肺移植 , 慢性拒絶反応 , IL-6 , Th17

Research theme for competitive and other funds (25)：

2023 - 2027 がん間質FAPI PETイメージングにおける集積の生物学的背景と臨床的意義の解明
2023 - 2026 胸腺上皮性腫瘍の腫瘍間質をターゲットとした治療戦略の探索
2022 - 2025 肺癌の間質形成と肺線維化における線維芽細胞を標的とした新規免疫療法の基盤確立
2022 - 2025 肺がんにおける癌関連線維芽細胞の機能解析と新規治療戦略の提案
2022 - 2025 ペリオスチンを基軸とした間質性肺炎合併肺癌に対する包括的治療法の開発

2019 - 2023 Perspective of targeting cancer-associated fibroblasts in non-small-cell lung cancer

2019 - 2022 Regenerating medicine using multilayered tissues with adipose derived stem cell for COPD

2019 - 2022 Development of novel treatment strategy against ischemia reperfusion lung injury after lung transplantation via the inhibition of necroptosis.

2019 - 2022 New Therapeutic Strategy for Lung Cancer with Interstitial Lung Diseases

2017 - 2020 Stem cell based therapy for lung regeneration

2016 - 2019 The mechanism of PD-L1 expression and the clinical significance

2015 - 2018 Perspective of targeting tumor microenvironment in non-small-cell lung cancer

2015 - 2018 New threapeutic strategy for lung transplantation

2015 - 2018 Sustained-release delivery of prostacyclin analogue(ONO-1301) enhances lung regeneration after pnuemonectomy in mice

2014 - 2017 Cell-based therapy in lung regenerative medicine using adipose tissue-derived stem cell and induced pluripotent stem cell

2013 - 2017 New molecular target for lung cancer using PPAR-gamma

2013 - 2016 New surgical strategy for lung cancer based on circulating tumor cells

2013 - 2016 The mechanism of metastasis of circulating tumor cells in non small cell lung cancer

2013 - 2016 The establishment of multimodal therapy of thymic epithelial tumors with podoplanin expression

2012 - 2015 Cytokine receptor dephosphorylation molecules target therapy for rejection after lung transplantation

2012 - 2015 Therapeutic Perspective of Tumor Microenvironment in Non-Small Cell Lung Cancer

2012 - 2015 Lung Regenerative Therapy Using Cell Sheets Releasing Cytokines for COPD Patients

2011 - 2014 Development of novel method to control chronic rejection after lung transplantation using suppression of IL-6 amplifier

2010 - 2011 Therapeutic perspective of tumor microenvironment in non-small-cell lung cancer.

2000 - 非小細胞肺癌におけるTS・DPD発現

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Papers (289)：

Yudai Miyashita, Takashi Kanou, Eriko Fukui, Takahiro Matsui, Toru Kimura, Naoko Ose, Soichiro Funaki, Yasushi Shintani. A Novel Peroxisome Proliferator-Activated Receptor Gamma/Nuclear Factor-Kappa B Activation Pathway is Involved in the Protective Effect of Adipose-Derived Mesenchymal Stem Cells Against Ischemia-Reperfusion Lung Injury. Transplantation proceedings. 2024. 56. 2. 369-379
Yoshiaki Yasumizu, Makoto Kinoshita, Martin Jinye Zhang, Daisuke Motooka, Koichiro Suzuki, Daisuke Okuzaki, Satoshi Nojima, Soichiro Funaki, Yasushi Shintani, Naganari Ohkura, et al. Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma. 2024
Yusuke Okuma, Yasushi Shintani, Ikuo Sekine, Takehito Shukuya, Koichi Takayama, Akira Inoue, Isamu Okamoto, Katsuyuki Kiura, Nobuyuki Yamamoto, Tomoya Kawaguchi, et al. Efficacy of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Metastatic Non-Small Cell Lung Cancer Patients with Poor Performance Status and Epidermal Growth Factor Receptor Mutations: Findings from the Japanese Lung Cancer Registry Database. Clinical lung cancer. 2024
Hiroto Ishida, Soichiro Funaki, Seiji Taniguchi, Eiichi Morii, Yasushi Shintani. Familial multiple endocrine neoplasia type 1 with intrathoracic low-grade fibromyxoid sarcoma. Surgical case reports. 2024. 10. 1. 16-16
Seiki Hasegawa, Yasushi Shintani, Teruhisa Takuwa, Keisuke Aoe, Katsuya Kato, Nobukazu Fujimoto, Yasuhiro Hida, Masahiro Morise, Yasumitsu Moriya, Takao Morohoshi, et al. Nationwide prospective registry database of patients with newly diagnosed untreated pleural mesothelioma in Japan. Cancer science. 2023

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MISC (592)：

宮下裕大, 舟木壮一郎, 松本遼太, 島村和男, 倉谷徹, 新谷康. An infected aortic aneurysm after thoracic endovascular aneurysm repair successfully treated by VATS: A report of two cases. 日本呼吸器外科学会雑誌(Web). 2022. 36. 1
米田翠, 平田陽彦, 白山敬之, 山本悠司, 久下朋輝, 松本錦之介, 山本真, 三宅浩太郎, 狩野孝, 南正人, et al. The selection and prognosis of lung transplant candidates in our hospital. 日本呼吸器学会誌(Web). 2022. 11
森村祐樹, 田中里奈, 松原慧, 田中真, 狩野孝, 山田義人, 豊洋次郎, 大角明宏, 中島大輔, 濱路政嗣, et al. 小児肺移植の適応疾患と長期予後:多施設共同後ろ向き研究. 日本移植学会総会プログラム抄録集. 2022. 58th (Web)
服部可奈, 松田智大, シャルヴァ・アドリアン, 査凌, Lim Jiwon, Won Young-Joo, Chiang RuRu Chun-Ju, 堀之内秀仁, 新谷康, 祖父江友孝. なぜ,日本の肺がん5年生存率は他国に比べて高いのか?. 肺癌. 2021. 61. 6. 661-661
安水良明, 村田尚, 木下允, 城戸完介, 小原正治, 野島聡, 森井英一, 新谷康, 大倉永也, 坂口志文, et al. 一細胞RNAseq解析による重症筋無力症特異的な神経関連分子発現を行う胸腺上皮細胞の同定. 神経免疫学. 2021. 26. 1. 101-101

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Education (2)：

2000 - 2004 大阪大学大学院医学系研究科未来医療開発専攻
1989 - 1995 Osaka University Faculty of Medicine

Work history (2)：

2019/04 - 現在 Osaka University General Thoracic Surgery Professor
2015/09 - 現在 Osaka University

Committee career (1)：

American association for cancer research association member

Awards (6)：

2018/11 - 日本肺癌学会日本肺癌学会篠井・河合賞肺癌微小環境を標的とした肺癌治療の開発
2014/05 - 日本呼吸器外科学会日本呼吸器外科学会賞
2010/03 - 財団法人武田科学振興財団武田科学振興財団医学系研究奨章
2009/12 - 大阪から肺癌をなくす会研究奨励賞
2009/02 - 財団法人大阪対がん協会研究奨励賞

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Association Membership(s) (10)：

日本癌治療学会 , American association for cancer research , 日本視鏡外科学会 , 日本呼吸器外科学会 , 日本胸部外科学会 , 日本癌学会 , 日本消化器外科学会 , 日本肺癌学会 , 日本呼吸器学会 , 日本外科学会

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