Rchr
J-GLOBAL ID:201401061451504751   Update date: Mar. 29, 2024

Yamaguchi Takuya

ヤマグチ タクヤ | Yamaguchi Takuya
Affiliation and department:
Job title: Assistant Professor
Research field  (2): Applied biochemistry ,  Bioorganic chemistry
Research keywords  (7): millipede ,  Genome analysis ,  cytochrome P450 ,  plant specialized metabolites ,  herbicide ,  UDP-glycosyltransferase ,  enzyme
Research theme for competitive and other funds  (7):
  • 2023 - 2026 Unraveling the mechanism behind enhanced herbicide selectivity by safeners through molecular cross-species analyzes of crop and weed.
  • 2022 - 2025 Bio- and digital technologies for the enzyme development and application for pharmaceutical synthesis
  • 2020 - 2023 植物の新規ニトロ基合成酵素の分布と基質認識に関与する構造の解明
  • 2017 - 2022 動植物酵素の異種宿主における可溶性発現技術の開発とそれらの有用物質生産への利用
  • 2019 - 2022 イネと除草剤抵抗性タイヌビエ由来除草剤無毒化酵素CYP81Aの大腸菌発現系の構築と機能解析
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Papers (31):
  • Siriporn Chaikaew, Yukio Watanabe, Daijun Zheng, Fumihiro Motojima, Takuya Yamaguchi, Yasuhisa Asano. Structure-Based Site-Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for hydrocyanation and Henry reactions. ChemBioChem. 2024
  • Takuya Yamaguchi, Yasuhisa Asano. Nitrile-synthesizing enzymes and biocatalytic synthesis of volatile nitrile compounds: A review. Journal of Biotechnology. 2024
  • Takuya Yamaguchi. Exploration and utilization of novel aldoxime, nitrile, and nitro compounds metabolizing enzymes from plants and arthropods. Bioscience, Biotechnology, and Biochemistry. 2024
  • Takuya Yamaguchi, Takuya Nomura, Yasuhisa Asano. Identification and characterization of cytochrome P450 CYP77A59 of loquat (Rhaphiolepis bibas) responsible for biosynthesis of phenylacetonitrile, a floral nitrile compound. Planta. 2023. 257. 6. 114
  • Hiroe Suda, Tomomi Kubo, Yusuke Yoshimoto, Keisuke Tanaka, Satoru Tanaka, Akira Uchino, Satoshi Azuma, Makoto Hattori, Takuya Yamaguchi, Masahiro Miyashita, et al. Transcriptionally linked simultaneous overexpression of P450 genes for broad-spectrum herbicide resistance. Plant Physiology. 2023
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MISC (6):
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Patents (4):
  • ヒドロキシニトリルリアーゼ
  • モノオキシゲナーゼ及びこれを用いる(R)-マンデロニトリルの製造方法
  • マンデロニトリル酸化酵素
  • 核酸、シトクロムP450、およびマンデロニトリル誘導体の製造方法
Lectures and oral presentations  (52):
  • 動植物のアルドキシムを介したニトリルやニトロ化合物の代謝に関する研究
    (公益社団法人 日本農芸化学会 中部支部 第197回例会 2023)
  • Discovery of CYP94A and CYP77A fatty acid hydroxylases that metabolize aldoxime in floral nitro and nitrile compounds biosynthesis in loquat
    (The international joint meeting of the 23rd International Conference on Cytochrome P450 (ICCP450) and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics (JSSX) 2023)
  • Microbial production of glucosides using UDP-glucosyltransferases and UDP-glucose biosynthetic enzymes
    (3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development 2023)
  • ビワ由来新規フェニルアセトニトリル生合成酵素CYP77Aの同定と性状解析
    (生物工学若手研究者の集い 夏のセミナー2023 2023)
  • 大腸菌におけるUDP-グルコース供給系とUDP-グルコース転移酵素を用いた有用配糖体の生産
    (生物工学若手研究者の集い 夏のセミナー2023 2023)
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Education (3):
  • 2009 - 2012 Hokkaido University Graduate School of Agriculture
  • 2007 - 2009 Hokkaido University Graduate School of Agriculture
  • 2002 - 2007 Hokkaido University Faculty of Agriculture Department of Applied Bioscience
Professional career (1):
  • PhD (Hokkaido University)
Work history (5):
  • 2021/04 - 現在 Toyama Prefectural University Faculty of Engineering
  • 2016/11 - 2021/03 University of Tsukuba Faculty of Life and Environmental Sciences
  • 2012/04 - 2016/10 Toyama Prefectural University
  • 2009/04 - 2012/03 Japan Society for the Promotion of Science
  • 2011/02 - 2011/05 Pioneer Hi-Bred International (DuPont) Intern
Awards (5):
  • 2023/03 - Hot Topics Award at Annual Meeting of JSBBA 2023
  • 2023/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Award for Young Scientists
  • 2023/03 - The Best Paper Award for Weed Biology and Management for 2022 Heterologous expression of CYP81A6 from rice (Oryza sativa) in Escherichia coli and structural analyses of bensulfuron-methyl metabolites
  • 2019/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Prunasin production using engineered Escherichia coli expressing UGT85A47 from Japanese apricot and UDP-glucose biosynthetic enzyme genes
  • 2016/04 - Hot Topics Award at Annual Meeting of JSBBA 2016
Association Membership(s) (4):
JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY ,  The Molecular Biology Society of Japan ,  THE JAPANESE SOCIETY OF SERICULTURAL SCIENCE ,  THE WEED SCIENCE SOCIETY OF JAPAN
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