Rchr
J-GLOBAL ID：201401061522238659
Update date: Jan. 30, 2024
Nakagawa Tadashi
ナカガワ タダシ | Nakagawa Tadashi
Affiliation and department：
Job title：
Assistant Professor
Other affiliations (1)：
Homepage URL (2)：
http://db.tohoku.ac.jp/whois/detail/bf3064b8defea88a3dbb225cbca93a47.html
,
http://db.tohoku.ac.jp/whois/e_detail/bf3064b8defea88a3dbb225cbca93a47.html
Research field (5)：
Pharmacology
, Laboratory animal science
, Neuropathology
, Cell biology
, Molecular biology
Research keywords (6)：
Autism
, 筋萎縮性側索硬化症
, 知的障害
, タンパク質分解
, Chromatin
, Ubiquitin
Research theme for competitive and other funds (10)：
- 2022 - 2025 Do Food Additives Cause Obesity?-Elucidation of the mechanism of action on leptin receptor signaling-
- 2021 - 2024 SETD5の膵臓癌における機能
- 2020 - 2023 DNA損傷時のユビキチンリガーゼRNF126による転写制御メカニズムの解明
- 2017 - 2021 Functional analysis of ubiquitin ligase RNF126
- 2018 - 2020 Elucidation of the signaling pathways that induce gene amplification
- 2019 - Investigation of novel ALS/FTLD therapeutics that target RNA
- 2017 - 2019 Development of RNA-targeted novel therapeutics against ALS
- 2015 - 2017 Elucidation of protein degradation-mediated ALS pathogenesis regulated by cytosolic RNA
- 2015 - 2016 Verification of genomic diversity required for tumorigenesis
- 2013 - 2015 Elucidation of novel regulatory mechanism of basic transcription factor during cell differentiation
Show all
Papers (31)：
-
Tadashi Nakagawa, Akane Morohoshi, Yuko Nagasawa, Makiko Nakagawa, Masaki Hosogane, Yasuhiro Noda, Toru Hosoi, Keiko Nakayama. SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones. Cell reports. 2022. 38. 12. 110541-110541
-
Tadashi Nakagawa, Satoko Hattori, Toru Hosoi, Keiko Nakayama. Neurobehavioral characteristics of mice with SETD5 mutations as models of IDD23 and KBG syndromes. Frontiers in genetics. 2022. 13. 1022339-1022339
-
Shio Mitsuzawa, Naoki Suzuki, Tetsuya Akiyama, Mitsuru Ishikawa, Takefumi Sone, Jiro Kawada, Ryo Funayama, Matsuyuki Shirota, Hiroaki Mitsuhashi, Satoru Morimoto, et al. Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations. Stem cell reports. 2021. 16. 6. 1527-1541
-
Lei-Lei Chen, Matthew D Smith, Lei Lv, Tadashi Nakagawa, Zhijun Li, Shao-Cong Sun, Nicholas G Brown, Yue Xiong, Yan-Ping Xu. USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. Science advances. 2020. 6. 38
-
Yasuaki Watanabe, Tadashi Nakagawa, Tetsuya Akiyama, Makiko Nakagawa, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Keiko Nakayama. An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3. iScience. 2020. 23. 9. 101491-101491
ｍore...
MISC (6)：
-
Theodora U.J. Bruun, Caro Lyne Desroches, Diane Wilson, Vann Chau, Tadashi Nakagawa, Masahiro Yamasaki, Shinya Hasegawa, Toshiyuki Fukao, Christian Marshall, Saadet Mercimek-Andrews. Prospective Cohort Study for Identification of Underlying Genetic Causes in Neonatal Encephalopathy Using Whole-Exome Sequencing. Obstetrical and Gynecological Survey. 2018. 73. 10. 564-565
-
Tadashi Nakagawa, Lei Lv, Makiko Nakagawa, Yanbao Yu, Chao Yu, Ana C. D'Alessio, Keiko Nakayama, Heng-Yu Fan, Xian Chen, Yue Xiong. CRL4(VprBP) E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases (vol 342, pg 1518, 2013). MOLECULAR CELL. 2015. 59. 6
-
中川 直, 中山 啓子, Yue Xiong. ユビキチンリガーゼ複合体CRL4VprBPはTETタンパク質のモノユビキチン化およびクロマチンとの結合を促進する. ライフサイエンス新着論文レビュー "http://first.lifesciencedb.jp/archives/9768". 2015
-
中川 直, Yue Xiong. X染色体性知的障害の原因タンパク質CUL4BはWDR5のユビキチン化にはたらくことで神経に特異的な遺伝子の発現を制御する. ライフサイエンス新着論文レビュー "http://first.lifesciencedb.jp/archives/3507". 2011
-
Tadashi Nakagawa. X-linked intellectual disability gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. 2011. 30. 1076-1077
ｍore...
Lectures and oral presentations (24)：
-
Autism-related protein SETD5 controls neural proliferation by epigenetic regulation of rDNA expression
(The 10th Takeda Science Foundation Symposium on PharmaSciences 2020)
-
Epigenetic regulation of rDNA by intellectual disability and autism-related protein SETD5
(The 42th annual meeting of the molecular biology society of Japan 2019)
-
Pathogenesis of ALS by impaired protein degradation
(42th Annual meeting of the Japan Neuroscience Society 2019)
-
Mutation of cyclin F may contribute to Amyotrophic Lateral Sclerosis pathogenesis by affecting VCP ATPase activity
(41th Annual meeting of the molecular biology society of Japan 2018)
-
Regulation of FACT complex by ubiquitylation
(41th Annual meeting of the molecular biology society of Japan 2018)
ｍore...
Education (3)：
- 2004 - 2008 Kyushu University Graduate School of Medicine Medical Instutute of Bioregulation
- 2002 - 2004 Hokkaido University Graduate School of Pharmaceutical Sciences Department of Pharmacology
- 1998 - 2002 Hokkaido University Department of Pharmaceutical Science
Professional career (1)：
- 博士(医学) (Kyushu University)
Work history (4)：
- 2020/04 - 現在 Tohoku University
- 2020/04 - 現在 Sanyo-Onoda City University Department of Clinical Pharmacology Junior Associate Professor
- 2013/04 - 2020/03 Graduate School of Medicine, Tohoku University Division of Cell Proliferation Assistant Professor
- 2008/04 - 2013/03 University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center Post-doctoral fellow
Committee career (2)：
- 2020/04 - 現在 山陽小野田市立山口東京理科大学 環境安全センター運営委員
- 2014/11 - 2020/03 東北大学 大学院医学系研究科 安全衛生委員
Awards (2)：
- 2012/10 - University of North Carolina Postdoctoral Award for Research Excellence
- 2005/11/03 - 文部科学省特定領域 第7回 “タンパク質の一生” 国際会議 ポスター賞
Association Membership(s) (1)：
Return to Previous Page
