Research keywords (16)：
Elastin
, Caspase14
, Cathepsin B
, BACE2
, BACE1
, ADAM
, Kampo medicine
, TMPRSS2
, ACE2
, SARS-CoV-2
, Skin whitening
, Wrinkle formation
, Natural moisturizing factor
, Dermatology
, Dementia
, Neprilysin
Research theme for competitive and other funds (5)：
2019 - 2023 Investigation of reduced expression and activity of an amyloid-degrading enzyme in Down syndrome
2016 - 2019 Search for new targets as potential anti-Alzheimer's disease agents from chromosome 21
2013 - 2016 Identification and functional analysis of endogenous factors modulating a cutout of Abeta from APP
2012 - 2015 Regulation of APP phosphorylation
2007 - 2008 Analysis of the mechanism action of a novel Aβ-lowering reagent KM3558 and administration of KM3558 to mice
Papers (29)：
Arakawa J, Kondoh H, Matsushita T, Ogino Y, Asai M, Tanuma SI, Uchiumi F. Induction of the human CDC45 gene promoter activity by natural compound trans-resveratrol. Mol Med Rep. 2024. 29. 6. 92
Iwasa K, Yagishita S, Yagishita-Kyo N, Yamagishi A, Yamamoto S, Yamashina K, Haruta C, Asai M, Maruyama K, Shimizu K, et al. Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment. Scientific Reports. 2023. 13. 1
Takihara Y, Otani R, Ishii T, Takaoka S, Nakano Y, Inoue K, Larsen S, Ogino Y, Asai M, Tanuma SI, et al. Characterization of the human IDH1 gene promoter. AIMS Molecular Science. 2023. 10. 3. 186-204
Nishizaki Y, Yoshida L, Isuzugawa T, Asai M, Sakai-Ushikubo H, Hayamizu K, Kuroiwa M, Kawashima Y, Kaneko M. A report on integrated virtual and observational methods in anatomy education. 2023. 7
Kikegawa M, Nakajima A, Yu J, Asai M, Uesawa Y, Sone H. Molecular profiling of ginsenoside metabolites to identify estrogen receptor alpha activity. Gene. 2022. 813. 146108
