Rchr
J-GLOBAL ID:201401070053710782
Update date: Feb. 01, 2024
Ohnishi Hiroe
オオニシ ヒロエ | Ohnishi Hiroe
Affiliation and department:
Job title:
Program Specific Assistant Professor
Research field (2):
Otorhinolaryngology
, Medical biochemistry
Research keywords (5):
鼻腔上皮
, 喉頭
, trachea
, inner ear
, stem cell
Research theme for competitive and other funds (24):
- 2023 - 2026 マクロファージ動態制御による声帯線維化予防技術開発
- 2023 - 2026 ヒトiPS細胞由来気道上皮シート鼻腔移植モデルの作製
- 2022 - 2026 Novel Hearing Loss Treatment by Cochlear Nerve Regeneration from Cell Transplantation and Differentiation Transformation Accelerated by Photostimulated Cochlear Implant
- 2022 - 2026 Development of a Novel Hearing Loss Treatment by Integrating Photostimulated Cochlear Implant Technology and iPS Cell Transplantation Cochlear Nerve Regeneration
- 2023 - 2025 Diversity and Alteration of the phenotype of cochlear resident macrophates during development
- 2022 - 2025 Exploration of factors for improvement of the engraftment efficiency in human iPS cell-derived airway epithelial cell transplantation.
- 2022 - 2025 Elucidation of Inner Ear Development Mechanisms using multi-omics
- 2021 - 2025 ヒト多能性幹細胞(iPS細胞)由来内耳オルガノイドの内耳移植による内耳再生研究
- 2021 - 2024 Elucidation of the cochlear development and inner ear pathology with imaging mass-spectrometry for the treatment of sensorineural hearing loss
- 2021 - 2024 内耳蝸牛三次元構造形成メカニズムの解明と蝸牛型オルガノイド作製への応用
- 2021 - 2023 CRISPR/Cas系による新型コロナウイルス感染と気道上皮バリア破壊機構の解明
- 2020 - 2023 Mechanisms for the initial process of hair cell regeneration in avian inner ears
- 2020 - 2023 マクロファージ極性制御による上気道線維化病変に対する新規治療技術開発
- 2020 - 2023 宇宙環境における内耳前庭の発生維持とバイオメカニクス
- 2019 - 2022 蝸牛感覚上皮発生メカニズムの解明-単一細胞レベルでの感覚上皮マーカーの探索
- 2017 - 2021 人工内耳技術と蝸牛神経再生の融合による新規性難聴治療法の開発
- 2018 - 2020 蝸牛・前庭感覚上皮発生機序の解析とヒトiPS細胞を用いた難聴モデル作製への応用
- 2017 - 2020 The comprehesive analysis of human hereditary deafness
- 2017 - 2020 『平衡障害に対する新規治療法の開発』- ヒトiPS細胞による前庭再生医療 -
- 2017 - 2020 蝸牛におけるIGF1-Netrin axisの役割解明と応用創薬研究
- 2016 - 2017 マウスおよびヒトiPS細胞を用いた頭頸部組織の再生技術開発
- 2016 - 2017 ヒトiPS細胞を用いた内耳有毛細胞および前駆細胞特異的表面マーカーの探索
- 2015 - 2017 色素性乾皮症患者由来iPS細胞を用いた感音性難聴発症機構の解析と疾患モデルの開発
- 2013 - 国際学会派遣助成
Show all
Papers (51):
-
Yasuyuki Hayashi, Hiroe Ohnishi, Masayuki Kitano, Yo Kishimoto, Toshiaki Takezawa, Hideaki Okuyama, Masayoshi Yoshimatsu, Fumihiko Kuwata, Takeshi Tada, Keisuke Mizuno, et al. Comparative study of immunodeficient rat strains in engraftment of hiPSC-derived airway epithelia. Tissue Engineering Part A. 2023
-
Yuji Kitada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Masayuki Kitano, Keisuke Mizuno, Koichi Omori. Transplantation of Induced Pluripotent Stem Cell-Derived Airway Epithelia with a Collagen Scaffold into the Nasal Cavity. Tissue Engineering Part C: Methods. 2023. 29. 11. 526-534
-
Mami Matsunaga, Ryosuke Yamamoto, Tomoko Kita, Hiroe Ohnishi, Norio Yamamoto, Takayuki Okano, Koichi Omori, Takayuki Nakagawa. Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium. iScience. 2023. 26. 2
-
Keisuke Mizuno, Hiroe Ohnishi, Masayoshi Yoshimatsu, Chengzhu Zhao, Yasuyuki Hayashi, Fumihiko Kuwata, Shinji Kaba, Hideaki Okuyama, Yoshitaka Kawai, Nao Hiwatashi, et al. Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells. Cell Transplantation. 2023. 32. 096368972311784-096368972311784
-
Yuki Tanigami, Yoshitaka Kawai, Shinji Kaba, Ryuji Uozumi, Hiroe Ohnishi, Tomoko Kita, Koichi Omori, Yo Kishimoto. Establishment of a radiation-induced vocal fold fibrosis mouse model. Biochemical and biophysical research communications. 2022. 601. 31-37
more...
MISC (3):
-
桑田文彦, 大西弘恵, 奥山英晃, 北田有史, 山下勝, 小林正佳, 山本典生, 大森孝一. コラーゲンビトリゲル膜を用いたヒトiPS細胞由来気道上皮細胞のラット鼻腔への移植. 日本耳鼻咽喉科学会会報. 2021. 124. 4
-
田浦 晶子, 大西 弘恵, 西村 幸司, 扇田 秀章, 中川 隆之, 山本 典生, 岡野 高之, 大森 孝一, 伊藤 壽一. 基礎研究の将来展望 前庭再生医療研究の将来展望. Equilibrium Research. 2019. 78. 3. 219-227
-
Hiroe Ohnishi, Takuo Nakahara, Kyoko Furuse, Hiroyuki Sasaki, Shoichiro Tsukita, Mikio Furuse. JACOP: A novel cytoplasmic plaque protein localizing at the apical junctional belt. CELL STRUCTURE AND FUNCTION. 2004. 29. 48-48
Patents (1):
Books (11):
-
「iPS細胞の安全・高品質な作製技術、第6章、第4節 ヒトiPS細胞からの前庭神経節細胞作製の開発」
株式会社 技術情報協会 2016
-
In Regenerative Medicine for the Inner Ear (Ito J. Ed)
Springer Japan KK 2014
-
Otic induction (Chapter 11). In Regenerative Medicine for the Inner Ear (Ito J. Ed)
Springer Japan KK. 2014
-
Pluripotent stem cells. (Chapter 31). In Regenerative Medicine for the Inner Ear (Ito J. Ed)
Springer Japan KK. 2014
-
Allogeneic Mesenchymal Stem Cells for Bone Tissue Engineering: Clinical Experience of Perinatal Hypophosphatasia Patient”, Stem cells and Bone tissue, Chapter 17
CRC Press. 2013
more...
Lectures and oral presentations (7):
-
ヒトiPS細胞由来間葉系幹細胞移植によるX-SCIDラット甲状軟骨再生研究
(第15回 ラットリサーチ研究会 2022)
-
Trial for Improvement of Hair Cell Induction Method from Human Induced Pluripotent Stem Cell.
(Association for Research in Otolaryngology 42th MidWinter Meeting 2019)
-
ビトリゲル上でのヒトiPS細胞からの気道上皮細胞分化誘導
(第16回 日本再生医療学会総会 2017)
-
段階的分化誘導法を用いたヒトiPS細胞からの内耳有毛細胞様細胞の誘導
(第33回 耳鼻咽喉科ニューロサイエンス研究会 2015)
-
Differentiation of Human Induced Pluripotent Stem Cells into Glutamatergic Neurons on 3D Scaffolds.
(Inner Ear Biology Workshop 2014)
more...
Education (2):
- 2000 - 2004 Kyoto University Graduate School of Medicine
- 1998 - 2000 Nara Institute of Science and Technology Graduate School of Biological Sciences
Professional career (1):
Work history (7):
- 2022/04 - 現在 Kyoto University Department of Otolaryngology, Head and Neck Surgery Program Specific Assistant Professor
- 2018/04 - 2022/03 Kyoto University
- 2016/04 - 2018/03 Kyoto University
- 2012/04 - 2016/03 Kyoto University
- 2008/10 - 2012/03 産業技術総合研究所 セルエンジニアリング研究部門 組織・再生工学研究グループ 特別研究員
- 2007/04 - 2008/09 産業技術総合研究所 糖鎖医工学研究センター 分子医用技術開発チーム 特別研究員
- 2004/04 - 2007/03 Osaka University Research Institute for Microbial Diseases
Show all
Awards (1):
- Association for Research in Otolaryngology Travel Award Association for Research in Otolaryngology, “ARO Graduate Student / Postdoctoral Fellow Travel Award”
Association Membership(s) (4):
Association for Research in Otolaryngology, Regular Member
, THE JAPANESE SOCIETY OF INFLAMMATION AND REGENERATION
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Return to Previous Page