Im Dohyun

イムヒョン | Im Dohyun

Affiliation and department：
Job title： Assistant Professor

Research field (3)： Medical biochemistry , Neuroscience - general , Structural biochemistry

Research keywords (7)： Structural Biology , GPCR , Dopamin receptor , Histamine receptor , Neurotransmitter , Membrane protein , SBDD

Research theme for competitive and other funds (8)：

2023 - 2026 Development of Next-Generation GPCR-Targeted Drugs by Integrating Protein Engineering and Medicinal Chemistry
2023 - 2026 A new mechanism of drug selectivity for dopamine receptor
2022 - 2026 Structural Basis of the Signaling Biased Mechanism of Ghrelin Receptor
2023 - 2025 Gタンパク質共役型受容体のバイアスドリガンドの探索
2022 - 2024 ドパミン受容体の新規薬剤選択性機構の解明と創薬への応用

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Papers (14)：

Tsuyoshi Araya, Yuya Matsuba, Harufumi Suzuki, Tomohiro Doura, Nipawan Nuemket, Eriko Nango, Masaki Yamamoto, Dohyun Im, Hidetsugu Asada, Shigeki Kiyonaka, et al. Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor. Biochemical and biophysical research communications. 2024. 695. 149393-149393
Dohyun Im, Jun-Ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, et al. Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor. Nature communications. 2023. 14. 1. 6538-6538
Alexander M. Wolff, Eriko Nango, Iris D. Young, Aaron S. Brewster, Minoru Kubo, Takashi Nomura, Michihiro Sugahara, Shigeki Owada, Benjamin A. Barad, Kazutaka Ito, et al. Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography. Nature Chemistry. 2023
Hidetsugu Asada, Dohyun Im, Yunhon Hotta, Satoshi Yasuda, Takeshi Murata, Ryoji Suno, So Iwata. Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor. Structure (London, England : 1993). 2022. 30. 12. 1582-1589
Masayasu Toyomoto, Asuka Inoue, Kei Iida, Masatsugu Denawa, Isao Kii, Francois Marie Ngako Kadji, Takayuki Kishi, Dohyun Im, Tatsuro Shimamura, Hiroshi Onogi, et al. S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation. Cell chemical biology. 2021. 28. 8. 1132-1144

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Education (3)：

2010 - 2013 The University of Tokyo Graduate School of Agricultural and Life Sciences Biotechnology
2008 - 2010 The University of Tokyo Graduate School of Agricultural and Life Sciences Biotechnology
2001 - 2007 Korea University

Work history (3)：

2020/08 - 現在 Kyoto University Graduate School of Medicine
2018/04 - 2020/07 Otsuka Pharmaceutical Co., Ltd.
2013/04 - 2018/03 Kyoto University Graduate School of Medicine

Awards (2)：

2020 - Korea Biological Research Information Center (BRIC) Outstanding Korean Researcher
2012 - The Japan Society for Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry

Association Membership(s) (1)：

Protein Science Society of Japan

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