2020 - 2024 Why subarachnoid hemorrhage occure more frequentry in Japanese than other population?
2020 - 2023 Identification of therapeutic targets to prevent rupture of intracranial aneurysm.
2020 - 2023 Elucidation of the effect of Microorganism of the body on the origin and rupture of the intracranial aneurysms and development of preventive measure of the subarachnoid hemorrhage
2019 - 2022 Pathological and molecular analysis of cerebral aneurysms using live imaging
2018 - 2022 Analysis of rare variants in RNF213 in patients of cerebral aneurysm
2018 - 2021 Activatable Fluorescence Imaging of Macrophages in Cerebral Aneurysms Using Iron Oxide Nanoparticles Conjugated With Indocyanine Green
2018 - 2021 Elucidation of the onset mechanism of moyamoya disease by identifying pathway abnormalities
2016 - 2019 Contribution of T cell function to the pathogenesis of intracranial aneurysms.
2015 - 2018 Development of cell and molecular imaging and possible medical treatment for cerebral aneurysms
2014 - 2016 The mechanisms underlying the enlargement of intracranial aneurysm focused on hemodynamic stress loading
2012 - 2014 Clarification of mechanisms underlying the enlargement of intracranial aneurysms focused on drop-out of medial smooth muscle cells.
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Papers (105)：
Akihiro Okada, Kampei Shimizu, Akitsugu Kawashima, Tomomichi Kayahara, Masahiko Itani, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki. C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms. Scientific reports. 2024. 14. 1. 3105-3105
Anne F Cayron, Olivia Bejuy, Maria Isabel Vargas, Didier J Colin, Tomohiro Aoki, Karl-Olof Lövblad, Philippe Bijlenga, Brenda R Kwak, Eric Allémann, Sandrine Morel. Time-of-flight and black-blood MRI to study intracranial arteries in rats. European radiology experimental. 2024. 8. 1. 3-3
Isao Ono, Tomomichi Kayahara, Akitsugu Kawashima, Akihiro Okada, Susumu Miyamoto, Hiroharu Kataoka, Hiroki Kurita, Akira Ishii, Tomohiro Aoki. Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm. Scientific reports. 2023. 13. 1. 5545-5545
Isao Ono, Yu Abekura, Akitsugu Kawashima, Mieko Oka, Akihiro Okada, Shintaro Hara, Susumu Miyamoto, Hiroharu Kataoka, Akira Ishii, Kimiko Yamamoto, et al. Endothelial cell malfunction in unruptured intracranial aneurysm lesions revealed using a 3D-casted mold. Journal of neuropathology and experimental neurology. 2022. 82. 1. 49-56
Akihiro Okada, Hirokazu Koseki, Isao Ono, Tomomichi Kayahara, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki. Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2022. 31. 12. 106848-106848
2023/04 - 現在 Jikei University School of Medicine Department of Pharmacology Professor
2017/04 - 2023/03 National Cerebral and Cardiovascular Center Research Institute, Molecular Pharmacology
2012/08 - 2017/03 Kyoto University Graduate School of Medicine
2012/04 - 2012/07 Kyoto University Graduate School of Medicine
2009/04 - 2012/03 Kyoto University Graduate School of Medicine
Awards (3)：
2015 - 第31回日本薬理学会学術奨励賞
2012 - 第27回岡本研究奨励賞
2008 - 第32回日本心臓財団草野賞
Association Membership(s) (7)：
日本血管生物学会
, 日本分子脳神経外科学会
, 日本炎症再生学会
, JAPANESE SOCIETY OF BIORHEOLOGY
, THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE JAPAN STROKE SOCIETY
, The Japan Neurosurgical Society
