Kozaka Takashi

コザカタカシ | Kozaka Takashi

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://ri-center.w3.kanazawa-u.ac.jp/

Research field (1)： Radiology

Research keywords (1)： Organic synthetic chemistry, Radiopharmaceutical chemistry, Molecular imaging

Research theme for competitive and other funds (7)：

2020 - 2023 σ受容体を標的とした新規固形がんイメージング剤と抗がん剤の開発
2019 - 2022 Development of sigma-1 receptor imaging agent for early diagnosis of stress-related diseases
2017 - 2020 Development of a new sigma-2 receptor ligand for imaging and BNCT
2014 - 2017 アルツハイマー病の早期診断用シナプス前コリン作動性神経分子イメージング剤の開発
2014 - 2016 固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究

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Papers (35)：

Hiroshi Wakabayashi, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Yoji Kitamura, Kazuma Ogawa, Seigo Kinuya, Junichi Taki. 125I-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (125I-OI5V) imaging visualized augmented sigma-1 receptor expression according to the severity of myocardial ischemia. Journal of Nuclear Cardiology. 2022
Hiroshi Wakabayashi, Junichi Taki, Hiroshi Mori, Tomo Hiromasa, Norihito Akatani, Anri Inaki, Takashi Kozaka, Kazuhiro Shiba, Kazuma Ogawa, Seigo Kinuya. Visualization of Dynamic Expression of Myocardial Sigma-1 Receptor After Myocardial Ischemia and Reperfusion Using Radioiodine-Labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5V) Imaging. Circulation journal : official journal of the Japanese Circulation Society. 2021. 85. 11. 2102-2108
Taiki Shigeno, Takashi Kozaka, Yoji Kitamura, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT. Annals of nuclear medicine. 2021. 35. 2. 167-175
Daisuke Miwa, Yoji Kitamura, Takashi Kozaka, Taiki Shigeno, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. (-)-o-[11 C]methyl-trans-decalinvesamicol ((-)-[11 C]OMDV) as a PET ligand for the vesicular acetylcholine transporter. Synapse (New York, N.Y.). 2020. 74. 11. e22176
Tuyen Thuy Bich Ho, Alessandro Nasti, Akihiro Seki, Takuya Komura, Hiiro Inui, Takashi Kozaka, Yoji Kitamura, Kazuhiro Shiba, Taro Yamashita, Tatsuya Yamashita, et al. Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis. Journal for immunotherapy of cancer. 2020. 8. 2

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MISC (1)：

K. Ogawa, H. Kanbara, K. Shiba, Y. Kiyono, T. Mori, Y. Kitamura, T. Kozaka, T. Kiwada, A. Odani. Development and evaluation of a radiobromine labeled sigma ligand for tumor imaging. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011. 38. S147-S147

Lectures and oral presentations (58)：

Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests
(137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
The structure-activity relationship between structure of vesamicol analogs and affinity of VAChT and sigma receptors.
(137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
The possibility of vesamicol analog with 5-membered ring as a sigma-1 receptor imaging probe
(137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
Changes of the dopamine nerve system by stress in the model mouse for 15q duplication.
(137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
SPECT用σ-2受容体イメージング剤[<sup>123</sup>I]PIDVの開発研究
(第56回日本核医学会学術総会 2016)

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Professional career (1)：

博士(薬学)

Association Membership(s) (6)：

Society of Nuclear Medicine and Molecular Imaging , Japanese Society of Radiation Safety Management , Japan Radioisotope Association , Japanese Society for Molecular Imaging , The Pharmaceutical Society of Japan , The Japanese Society of Nuclear Medicine

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