Research field (6)：
Pharmaceuticals - analytical and physicochemistry
, Molecular biochemistry
, Biochemistry
, Pharmaceuticals - chemistry and drug development
, Biophysics
, Digestive surgery
2017 - 2021 Development of new technologies for liver surgery by using fluorescent imaging
2017 - 2020 Development of indocyanine green-binding anti-cancer drug with specific accumulation in hepatocellular carcinoma
2017 - 2020 Development of a new pancreatic fistula prevention material via pancreatic fluid-responsive crosslinking
2016 - 2019 糖加水分解酵素蛍光プローブ群の開発による新規迅速がんイメージング手法の確立
2016 - 2019 Development of photodynamic therapy probes for cancer with single cell resolution and their evaluation with clinical samples
2015 - 2019 Promotion of oxygen biology on the basis of international networks
2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life
2014 - 2019 Development of imaging probes and caged compounds for oxygen biology researches
2015 - 2017 Single molecule imaging of endogenous protein in living cells using spontaneously blinking fluorophore
2014 - 2017 Detection of head and neck cancer by spraying cancer-specific fluorescent probe
2014 - 2016 Establishment of induced neurons (iN cells) derived from lysosomal disease patients involving neurological symptoms and elucidation of regulatory mechanism of neurodegeneration
2013 - 2016 Mechanism of neuronal cell death in GM2 gangliosidosis
2011 - 2016 Establishment of new diagnostic imaging system for hepatocellular carcinoma and its application to cancer therapy
2011 - 2016 Development of molecular probes and photo manipulation tools - Technologies for visualization and control of small number of biomolecules
2012 - 2015 Regulation of neutrophil extracellular traps via fenton reaction and its application to the treatment of refractory autoimmune vasculitis
2011 - 2014 Development of novel luciferin analogues for utilizing luciferases as new functional tools in vivo
2011 - 2014 Development of fluorescence-guided HPB surgery and application of indocyanine green-fluorescence imaging to photodynamic therapy for liver cancer
2008 - 2014 Signaling Functions of Reactive Oxygen Species
2008 - 2012 Development of novel fluorescence probes and imaging technologies for elucidating the mechanism of cellular signaling and responses induced by ROS
2007 - 2010 Development of functional anti-cancer molecules based on precise control of excitation and relaxation pathways
2008 - 2008 in situがん細胞特性診断を可能とする蛍光プローブの開発とその応用
2007 - 2008 生体分子の高次デジタル計測を実現する光機能性プローブの開発とその応用
2004 - 2007 Development of Bioimaging Probes For In Vivo Application
2002 - 2006 Design and development of biological response modifiers
2003 - 2003 がん細胞中でのみ機能する、全く新しい原理に基づいた化学療法剤の開発
2001 - 2003 Development of novel caged compounds that can report the yield of uncaged products
2002 - 2002 がん細胞中でのみ機能する、全く新しい原理に基づいた化学療法剤の開発
2000 - 2002 STUDIES ON RATIONAL DESIGN PRINCIPLE FOR FLUORESCENCE ON/OFF SWITCHING
2000 - 2002 DEVELOPMENT OF FUNCTIONAL FLUORESCENT PROBES FOR BIOIMAGING
2001 - 2001 がん細胞中でのみ機能する、全く新しい原理に基づいた化学療法剤の開発
2000 - 2001 フルオレセイン類の蛍光On/Off原理の解明とその蛍光プローブ創製への応用
1999 - 2001 Investigation on the Chemical Property of Heme Thiolate Structure and Application to Medicinal Chemistry
1998 - 1999 酸化活性種の新規反応特性評価法に基づく、高選択的な不活性分子活性化系の構築
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Papers (288)：
Shingo Sakamoto, Hideto Hiraide, Mayano Minoda, Nozomi Iwakura, Misa Suzuki, Jun Ando, Chiharu Takahashi, Ikuko Takahashi, Kazue Murai, Yu Kagami, et al. Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening. Cell reports methods. 2024. 4. 1. 100688-100688
Yugo Kuriki, Mari Sogawa, Toru Komatsu, Minoru Kawatani, Hiroyoshi Fujioka, Kyohhei Fujita, Tasuku Ueno, Kenjiro Hanaoka, Ryosuke Kojima, Rumi Hino, et al. Modular Design Platform for Activatable Fluorescence Probes Targeting Carboxypeptidases Based on ProTide Chemistry. Journal of the American Chemical Society. 2023
Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, et al. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Scientific reports. 2023. 13. 1. 16456-16456
Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis/release regulators. 2023
Jingwen Shou, Ayumi Komazawa, Yuusaku Wachi, Minoru Kawatani, Hiroyoshi Fujioka, Spencer John Spratt, Takaha Mizuguchi, Kenichi Oguchi, Hikaru Akaboshi, Fumiaki Obata, et al. Super-resolution vibrational imaging based on photoswitchable Raman probe. Science advances. 2023. 9. 24. eade9118
