Yamazaki Daiju

ヤマザキダイジュ | Yamazaki Daiju

Affiliation and department：

Research field (7)： Cardiovascular surgery , Biomedical engineering , Medical biochemistry , Pharmaceuticals - health and biochemistry , Pharmacology , Clinical pharmacy , Physiology

Research keywords (9)：生体模倣システム , 収縮 , 三次元心筋組織 , Calcium signaling , SR/ER counter ion channel , TRIC channel , cardiac safety , Proarrhythmia , human induced pluripotent stem cell

Research theme for competitive and other funds (18)：

2021 - 2026 臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明
2020 - 2023 神経活動リズムを形成する過分極応答解析のためのイメージングデバイス開発
2019 - 2022 Physiological role of TRIC-B in heart hunction
2018 - 2021 ヒトiPS分化細胞技術を応用した医薬品の心毒性評価法の開発と国際標準化に関する研究
2017 - 2019 高純度な国産ヒトES/iPS 細胞由来肝細胞の安定的かつ安価な製造法の開発

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Papers (54)：

Tomohiko Irie, Daiju Yamazaki, Ruri Kikura-Hanajiri. A potential of methoxpropamine to be a widespread recreational drug: it blocks NMDA receptors and inhibits NMDA receptor-mediated synaptic transmission in a brain preparation of mice. Forensic Toxicology. 2021
Tomohiko Irie, Daiju Yamazaki, Ruri Kikura-Hanajiri. F-phenibut (β-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells. European journal of pharmacology. 2020. 884. 173437-173437
Stanley T Parish, Michael Aschner, Warren Casey, Marco Corvaro, Michelle R Embry, Suzanne Fitzpatrick, Darren Kidd, Nicole C Kleinstreuer, Beatriz Silva Lima, Raja S Settivari, et al. An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Regulatory toxicology and pharmacology : RTP. 2020. 112. 104592-104592
宮崎侑, 市村敦彦, 北山諒, 辻本真人, 山崎大樹, 西美幸, 竹島浩. カウンターイオンチャネルTRIC-Bの欠損はマウス成長板軟骨細胞において形態異常を引き起こす. 日本薬学会年会要旨集. 2020. 140年会. 28M-am06S
Xinyu Zhou, Ki Ho Park, Daiju Yamazaki, Pei-Hui Lin, Miyuki Nishi, Zhiwei Ma, Liming Qiu, Takashi Murayama, Xiaoqin Zou, Hiroshi Takeshima, et al. TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle. Circulation research. 2020. 126. 4. 417-435

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MISC (35)：

Yoshinori Ide, Michinori Ichikawa, Mariko Kobayashi, Kenji Tsubokura, Daiju Yamazaki, Yasunari Kanda, Yuko Sekino. Cardiac Safety Assessment Methods for Human iPSC-Derived Cardiomyocytes: A Voltage Sensitive Dye Imaging with a High-speed CMOS Sensor and a Non-staining Imaging with Polarizers. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017. 88. 180-180
Takashi Yoshinaga, Hiroyuki Ando, Tomohiko Taniguchi, Takaaki Uda, Wataru Yamamoto, Keiichi Asakura, Atsuko Ojima, Raku Shinkyo, Kiyomi Kikuchi, Tomoharu Osada, et al. Drug-Induced Torsadogenic Risk Prediction Using Human iPS Cell-Derived Cardiomyocytes and MEA System (II). JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017. 88. 190-190
Daiju Yamazaki, Yoshinori Ide, Yasunari Kanda, Yuko Sekino. Drug-Induced Proarrhythmic Testing Methods Using VSD and Calcium Indicator in FDSS/uCell. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017. 88. 190-190
Takashi Kitaguchi, Yuta Moriyama, Sanae Maeda, Tomohiko Taniguchi, Masakazu Ishimura, Hiroyuki Tashibu, Masao Oguchi, Atsuhiro Yamanishi, Etsushi Takahashi, Kaori Miyamoto, et al. Evaluation of Multi-electrode Array in Combination with Cor.4U Human iPS Cell-Derived Cardiomyocytes to Predict Drug-Induced QT Prolongation and Arrhythmia - Collaboration between CSAHi and JiCSA. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017. 88. 187-187
Hiroyuki Ando, Takashi Yoshinaga, Wataru Yamamoto, Keiichi Asakura, Tomohiko Taniguchi, Atsuko Ojima, Takaaki Uda, Raku Shinkyo, Kiyomi Kikuchi, Tomoharu Osada, et al. Drug-Induced Torsadogenic Risk Prediction Using Human iPS Cell-Derived Cardiomyocytes and MEA System (I). JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017. 88. 186-186

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Books (3)：

小胞体Ca2+放出におけるTRICチャネルの生理的役割
公益社団法人日本薬理学会 2010
小胞体におけるTRICチャネル機構
医学のあゆみ vol. 235, p341 2010
TRICチャネルの生理的機能
日本生化学会 2009

Education (3)：

2004 - 2007 Nagoya City University Graduate School of Pharmaceutical Sciences
2002 - 2004 Nagoya City University Graduate School of Pharmaceutical Sciences
1998 - 2002 Nagoya City University Medicin

Professional career (1)：

博士(薬学) (名古屋市立大学)

Work history (6)：

2018/08 - 現在 National Institute of Health Sciences Division of Pharmacology Section Chief
2015/01 - 2018/07 National Institute of Health Sciences Division of Pharmacology Senior Researcher
2011/08 - 2014/12 Kyoto University
2010/04 - 2011/07 Kyoto University
2009/04 - 2010/03 学術振興会特別研究員PD

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Awards (5)：

2019/06 - 一般社団法人日本毒性学会田辺賞
2016/09 - Safety Pharmacology Society Young Investigator poster award
2013/10 - 日本薬学会近畿支部日本薬学会近畿支部ポスター賞
2013/03 - 日本薬学会日本薬学会年会優秀発表賞
2012/01 - 日本薬学会近畿支部日本薬学会近畿支部奨励賞

Association Membership(s) (9)：

THE JAPANESE SOCIETY OF TOXICOLOGY , Society for Neuroscience , Biophysical Society , Safety Pharmacology Society , 日本安全性薬理研究会 , THE PHYSIOLOGICAL SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY , レギュラトリーサイエンス学会

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