Nakamura Yukihiro

ナカムラユキヒロ | Nakamura Yukihiro

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.jikei-pharm.com/

Research field (5)： Physiology , Pharmacology , Cell biology , Biophysics , Neuroscience - general

Research keywords (20)： calcium , presynaptic terminal , synaptic vesicle , cerebellum , brainstem , exocytosis , simulation , patch-clamp , neurotransmitter release , patch-clamp technique , potassium channel , neuron , physiology , synaptic transmission , brain, nerve , synapse , calcium channel , neuroscience , confocal microscopy , neural circuit

Research theme for competitive and other funds (5)：

2022 - 2025 Study on the spatio-temporal dynamics of calcium and glutamate coupling at sensory ribbon synapses.
2021 - 2024 Elucidation of Ca sparks in CNS presynaptic terminals
2017 - 2020 シナプスの短期可塑性を制御する即時放出可能シナプス小胞の空間分布の解明
2011 - 2012 Developmental changes in Ca channel density and single channel conductance at the presynaptic terminal of central nervous system
2008 - 2010 Developmental changes in calcium domain at the presynaptic terminal of the central synapse

Papers (15)：

Peter Koppensteiner, Pradeep Bhandari, Cihan Önal, Carolina Borges-Merjane, Elodie Le Monnier, Utsa Roy, Yukihiro Nakamura, Tetsushi Sadakata, Makoto Sanbo, Masumi Hirabayashi, et al. GABA B receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles. Proceedings of the National Academy of Sciences. 2024
土井宏, 橋口俊太, 中村行宏, 石川太郎, 田中章景. 研究者の最新動向脊髄小脳失調症新規モデルマウスを用いた病態解析. Precision Medicine. 2019. 2. 13. 1260-1266
Nakamura Y. EGTA Can Inhibit Vesicular Release in the Nanodomain of Single Ca2+ Channels. Frontiers in synaptic neuroscience. 2019. 11. 26
Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, et al. Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42. Neurobiology of disease. 2019. 130. 104516-104516
Fekete, A., Nakamura, Y., Yang, Y.-M., Herlitze, S., Mark, M.D., DiGregorio, D.A., Wang, L.-Y. Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules. Nature Communications. 2019. 10. 1. 826

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MISC (2)：

中村行宏, 高橋智幸. 脳科学辞典「カルシウムキレート剤」. 2018
中村行宏, 高橋智幸. 脳科学辞典「Held萼状シナプス」. 2016

Patents (1)：

Transgenic animals

Books (4)：

ラング・デール薬理学原書8版
丸善出版 2018 ISBN:9784621301708
脳・神経科学の研究ガイド
朝倉書店 2013 ISBN:9784254102598
Patch-clamp recording method in slices for studying presynaptic mechanisms
2012
最新パッチクランプ実験技術法
吉岡書店 2011 ISBN:9784842703589

Lectures and oral presentations (24)：

EGTA can inhibit vesicular release in the 'nanodomain' distance from Ca channels
(IBRO2019 2019)
Ca2+ gradients at the vicinity of the Ca2+ channel: a comparison between linearized buffer approximation and reaction-diffusion simulation
(The 41st Annual Meeting of the Japan Neuroscience Society 2018)
The estimate of spatial distribution of readily-releasable vesicles at a central presynaptic terminal
(The 95th Annual Meeting of the Physiological Society Meeting 2018)
Inhibition of nanodomain Ca-driven vesicular release by EGTA
(The 40th Annual Meeting of the Japan Neuroscience Society 2017)
EGTAによるナノドメインCaの抑制
(生理学研究所研究会「シナプス伝達の細胞分子調節機構」 2016)

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Association Membership(s) (3)：

Society for Neuroscience , THE JAPAN NEUROSCIENCE SOCIETY , PHYSIOLOGICAL SOCIETY OF JAPAN

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