Rchr
J-GLOBAL ID：201501012989857988
Update date: Apr. 17, 2024
Hirofumi Noguchi
ノグチ ヒロフミ | Hirofumi Noguchi
Affiliation and department：
Job title：
Professor
Research field (1)：
General surgery, pediatric surgery
Research theme for competitive and other funds (45)：
- 2023 - 2027 Induction of human pancreatic stem cells by novel transcription factors without Yamanaka factors
- 2023 - 2026 ヒト乳歯歯髄細胞への分子生物学的介入による幹細胞誘導とそれを用いた機能解析
- 2023 - 2026 新規生体内ゲノム編集法による低ホスファターゼ症モデルマウス作製とその応用
- 2022 - 2025 Induction of insulin secreting cell via human iPS cells derived from deciduous teeth using a novel organ culture method
- 2022 - 2025 人工間葉系幹細胞を用いた肺線維症モデルマウスに対する効果
- 2021 - 2024 Induction of tissue-specific stem cells by novel transcription factors and/or small-molecule compounds
- 2021 - 2024 歯の再生を目指したヒト乳歯歯髄幹細胞濃縮と機能解析
- 2019 - 2024 細胞骨格ダイナミクスに基づく分子輸送制御システムの解明と革新的癌創薬への新展開
- 2020 - 2023 Differentiatio of human stem cells into pancreatic islets using porcine body as in vivo bioreactor
- 2020 - 2023 Molecular biological approaches to gene therapy for hypophosphatosis
- 2020 - 2023 Functional analysis of alkaline phosphatase, a stem cell marker, using human deciduous dental pulp cells derived from the patient with Hypophosphatasia (HPP)
- 2019 - 2022 Development of the differentiation derivative methods from induced tissue-specific pancreatic stem cells using TASCL to insulin excretory cells
- 2018 - 2021 Development of culture method to promote differentiation induction of pancreatic beta cells
- 2018 - 2021 Isolation and characterization of somatic stem cells from human deciduous tooth-derived dental pulp cells by genetic engineering techniques
- 2017 - 2020 A study on molecular robotics blood glucose level control method with NOD mice
- 2017 - 2020 Regeneration of insulin producing cells from Human deciduous dental pulp cell derived iPS cells
- 2017 - 2019 初期胚特異抗原SSEA-1が高未分化iPS細胞を特定するマーカーであることの証明
- 2016 - 2019 Induction of human iTS-P and iTS-L cells using iPS cell technology
- 2016 - 2019 Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicationg RNA.
- 2016 - 2019 Development and usage of p38MAPK inhibitory peptides
- 2016 - 2019 Development of gene transfer to peripheral tissues surrounding tooth (GTPT) for the tissue around the root forming apex of juvenile mice and its application
- 2016 - 2019 The visualization of microtissues using near-infrared fluorescence endoscope
- 2016 - 2019 Regeneration strategy of the functional renal corpuscle using renal stem cells
- 2015 - 2019 Elucidation of the unitary regulation on the malignant transformation and androgen insensitivity in prostate cancer.
- 2015 - 2018 Development of cryopreservation system for cells and tissue constructs in regenerative medicine and transplantation
- 2014 - 2018 Continuous hypothermic machine perfusion preservation of pancreas for efficient islet transplantation
- 2015 - 2017 次世代型標的遺伝子破壊法CRISPR/Cas9システムの歯学領域への応用
- 2014 - 2017 The isolation of stem cells from the human exfoliated deciduous teeth by genetic engineering
- 2014 - 2017 Development of xeno-free human feeder cell with multi-function derived from the dental pulp cell
- 2013 - 2017 The tooth-format cellular differentiating regulation from iPSCs
- 2013 - 2017 Establishment and applicational research of androgen producing stem cells
- 2013 - 2017 Preferential enrichment and characterization of human dental pulp stem cell via a genetic engineering-based approach
- 2014 - 2016 A novel NFAT inhibitory peptide (RCAN-11R) provides immunosuppression.
- 2013 - 2016 The study of regeneration of fetal small intestinal mucosa on the denuded colon
- 2013 - 2016 Construction of a cytotoxicity and function evaluation system using combinatorial cell clusters with magnetic nanoparticles
- 2013 - 2016 Induction and isolation of renal stem cells and establishment of foundation for renal regeneration research.
- 2012 - 2015 Establishment of 4th generation of islet isolation and the clinical application
- 2012 - 2015 Oct-3/4, a member of the family of POU-domain transcriptional factors can be the promising markers for cancer stem cells.
- 2011 - 2015 Effectiveness for islet isolation by hypothermic machine perfusion presevation of pancreas
- 2011 - 2013 蛋白導入法を用いた新規免疫抑制剤の開発
- 2011 - 2013 Production and application of a dental hypoplasia mouse model using a specific organization and a cell disruption system
- 2011 - 2013 Enrichment of the tooth constitution cell derived from human iPS cells using an original technique
- 2005 - 2006 膵島移植成績向上のための新規免疫抑制剤開発、および膵島再生療法の臨床応用化
- 2005 - 2005 新規細胞導入ペプチドによる膵島移植後の生着率向上効果の検討
- 2005 - 2005 ヒト膵島分離後の膵非内分泌組織からの膵幹細胞の同定と膵β細胞への分化誘導法の確立
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Papers (285)：
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Junsei Taira, Ryuji Tsuda, Chika Miyagi-Shiohira, Hirofumi Noguchi, Takayuki Ogi. Cytoprotective Effect of Pteryxin on Insulinoma MIN6 Cells Due to Antioxidant Enzymes Expression via Nrf2/ARE Activation. Antioxidants. 2023. 12. 3. 693-693
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Hirofumi Noguchi, Yoshiki Nakashima, Masami Watanabe, Masayuki Matsushita, Masayoshi Tsukahara, Issei Saitoh, Chika Miyagi-Shiohira. Protocol for the generation of human induced hepatic stem cells using Sendai virus vectors. STAR protocols. 2022. 3. 4. 101884-101884
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Yoshitaka Miyamoto, Yumie Koshidaka, Katsutoshi Murase, Shoichiro Kanno, Hirofumi Noguchi, Kenji Miyado, Takeshi Ikeya, Satoshi Suzuki, Tohru Yagi, Naozumi Teramoto, et al. Functional Evaluation of 3D Liver Models Labeled with Polysaccharide Functionalized Magnetic Nanoparticles. Materials. 2022. 15. 21. 7823-7823
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Yoshiki Nakashima, Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Masayuki Matsushita, Masayoshi Tsukahara, Hirofumi Noguchi. Induced hepatic stem cells are suitable for human hepatocyte production. iScience. 2022. 25. 10. 105052-105052
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Natsumi Ibano, Emi Inada, Shinji Otake, Yuki Kiyokawa, Kensuke Sakata, Masahiro Sato, Naoko Kubota, Hirofumi Noguchi, Yoko Iwase, Tomoya Murakami, et al. The Role of Genetically Modified Human Feeder Cells in Maintaining the Integrity of Primary Cultured Human Deciduous Dental Pulp Cells. Journal of clinical medicine. 2022. 11. 20
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MISC (292)：
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柴田 幸蔵, 浦野 大智, 西村 勇姿, 野口 洋文, 湯川 博, 馬場 嘉信. ナノ量子センサーを用いた膵島細胞温度計測による機能相関の解明. Organ Biology. 2023. 30. 3. 123-123
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穴澤 貴行, 丸橋 繁, 小玉 正太, 後藤 昌文, 江口 英利, 丸山 通弘, 霜田 雅之, 野口 洋文, 伊藤 泰平, 剣持 敬, et al. 膵島移植の成績向上に必要な取り組み:One donor-One recipientは可能か? 膵島移植臨床試験 CIT-J003の結果と今後の発展への課題. 移植. 2023. 58. 総会臨時. 202-202
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野口 洋文. 膵島移植/膵再生. 糖尿病. 2023. 66. 1. 47-48
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柴田幸蔵, 浦野大智, 西村勇姿, 野口洋文, 湯川博, 湯川博, 湯川博, 馬場嘉信, 馬場嘉信, 馬場嘉信. ナノ量子センサーを用いた膵島細胞温度計測による機能相関の解明. Organ Biology (Web). 2023. 30. 3
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森口 航吏, 野口 洋文. 膵臓保存液への添加剤としてのAlvelestatとUlinastatinのブタ膵島分離の収量および膵島移植成績への影響の比較. 琉球医学会誌. 2022. 41. 1-4. 46-46
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Patents (12)：
Education (1)：
- 1990 - 1996 Okayama University Medical School Faculty of Medicine
Professional career (1)：
Work history (12)：
- 2014/08 - 現在 University of the Ryukyus Graduate School of Medicine Professor
- 2015 - 2023 University of the Ryukyus Faculty of Medicine
- 2012 - 2014 The Open University of Japan
- 2011 - 2014 (株)学術科学振興センター 代表取締役社長・センター長
- 2009 - 2010 ベイラー研究所 膵島再生部門 Director
- 2007 - 2009 ベイラー研究所 膵島移植部門 Associate Investigator
- 2006 - 2007 Nagoya University School of Medicine
- 2005 - 2006 日本学術振興会(受入大学:京都大学) 特別研究員(SPD)
- 2003 - 2005 京都大学附属病院 移植外科 医員
- 2002 - 2003 Harvard University
- 1998 - 2002 Okayama University
- 1996 - 1998 高知県立中央病院(現高知医療センター) 外科 研修医
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Awards (10)：
- 2019 - 琉球大学大学院医学研究科 平成30年度医学研究科 研究・教育業績評価優秀者表彰
- 2014 - 日本膵・膵島移植研究会 会長賞
- 2010 - American Transplant Congress 2010 Award of Excellent Lecture
- 2008 - 日本膵・膵島移植研究会 優秀演題賞
- 2008 - Rachmiel Levine Symposium Rachmiel Levine Scientific Achievement Award
- 2007 - Baylor Health Care System Employee Recognition Award
- 2006 - 日本肝胆膵外科学会 会長賞(2年連続)
- 2005 - 日本肝胆膵外科学会 会長賞
- 2005 - 岡山医学会 結城賞
- 2004 - 日本再生医療学会 優秀演題賞
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