Research theme for competitive and other funds (18):
2022 - 2025 うつ病における脳内テロメア短縮のメカニズムー動物モデルによる検討
2021 - 2024 うつ病の海馬テロメア長短縮に対するmiRNA制御機構の解明
2019 - 2022 The role of the amygdala in depression
2016 - 2019 Elucidation of neural mechanisms underlying fear memory using DREADD
2018 - 2019 うつ病における内分泌異常および生体リズム異常の 解明
2017 - 2019 ストレス/うつ/自殺-負のスパイラルを結ぶ分子機構の解明
2015 - 2018 Epigenetic effects of early life stress on adult hippocampal neurogenesis
2016 - 2018 うつ病における海馬と扁桃体の統合的理解を目指して
2018 - 武田薬品工業
2017 - うつ病における脳内グルココルチコイド受容 体-FKBP5調節系の役割
2014 - 2016 自殺感受性遺伝子の中枢神経系における機能解析
2011 - 2014 Functional develpment of 5-HT/GABA neurons in the raphe nuclei - postnatal stress and epigenetics
2012 - 2014 SSRI の抗不安作用における扁桃体 5-HT 神経系の役割
2009 - 2011 不安と衝動性の脳内神経機構の研究
2008 - 2010 Effects of early postnatal stress on the development of 5-HT/GABA co-localized neuron in the raphe nuclei
2007 - 2008 A study of neural circuits underlying stress regulation at the critical period during brain development
2007 - 2008 扁桃体を中心とした不安の脳内神経回路の研究
2007 - 幼若期ストレスが成熟後の脳機能に及ぼす影響
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Papers (85):
Naoya Suzuki, Sachiko Hiraide, Hiroki Shikanai, Takeru Isshiki, Taku Yamaguchi, Takeshi Izumi, Kenji Iizuka. Impaired monoamine neural system in the mPFC of SHRSP/Ezo as an animal model of attention-deficit/hyperactivity disorder. Journal of Pharmacological Sciences. 2024. 154. 2. 61-71
Toshiya Matsushima, Takeshi Izumi, Giorgio Vallortigara. The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions. Frontiers in Neuroscience. 2024. 18
Tsugumi Shindo, Hiroki Shikanai, Akane Watarai, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi. D-serine metabolism in the medial prefrontal cortex, but not the hippocampus, is involved in AD/HD-like behaviors in SHRSP/Ezo. European Journal of Pharmacology. 2022. 923. 174930-174930
Hiroki Shikanai, Kazuko Ikimura, Momoko Miura, Tsugumi Shindo, Akane Watarai, Takeshi Izumi. Separation and detection of D-/L-serine by conventional HPLC. MethodsX. 2022. 9. 101752-101752
Takeshi Hiramoto, Akira Sumiyoshi, Takahira Yamauchi, Kenji Tanigaki, Qian Shi, Gina Kang, Rie Ryoke, Hiroi Nonaka, Shingo Enomoto, Takeshi Izumi, et al. Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice. Molecular psychiatry. 2021. 27. 2. 929-938
YAMAGUCHI T, TSUJIMATSU A, KUMAMOTO H, IZUMI T, OHMURA Y, YOSHIDA T, YAMAMOTO T, YOSHIOKA M. Anxiolytic effects of yokukansan and serotonin 5-HT_<1A> receptors in rats. 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology. 2013. 33. 2. 71-72
Shikanai Hiroki, Yoshida Takayuki, Konno Kohtarou, Yamasaki Miwako, Izumi Takeshi, Ohmura Yu, Shimamura Keiichi, Watanabe Masahiko, Yoshioka Mitsuhiro. Unique neural characteristics of GAD67-containing 5-HTergic neurons in the rat dorsal raphe nucleus. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 65P
鹿内 浩樹, 吉田 隆行, 今野 幸太郎, 山崎 美和子, 泉 剛, 大村 優, 渡邊 雅彦, 吉岡 充弘. Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus. 北海道醫學雜誌 = Acta medica Hokkaidonensia. 2012. 87. 6. 288-288