Yohei Hayashi

ハヤシヨウヘイ | Yohei Hayashi

Affiliation and department：
Job title： Team Leader (Principal Investigator)
Homepage URL (2)： https://acd.brc.riken.jp/ja/ , http://www.riken.jp/research/labs/brc/ips_cell_adv_char_dev/

Research field (2)： Medical biochemistry , Cell biology

Research keywords (7)： induced pluripotent stem cells , Embryonic Stem cells , Cellular Reprogramming , Differentiation , Disease Modeling , Reprogramming , iPS Cells

Research theme for competitive and other funds (22)：

2023 - 2026 Cell fate decision by dose of transcription factors
2021 - 2025 Phenotypic screening of genome-edited Induced pluripotent stem cells
2021 - 2024 22q11.2症候群特異的iPS細胞由来神経堤の病態モデルでのゲノム編集応用
2020 - 2023 胆道閉鎖症特異的iPS細胞を用いた胆管発生およびその障害メカニズムの解明
2019 - 2022 Molecular dynamics of epigenomic transcriptional regulation by Klf4 in iPSC generation

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Papers (60)：

Kana Yanagihara, Yohei Hayashi, Yujung Liu, Tomoko Yamaguchi, Yasuko Hemmi, Minako Kokunugi, Kozue Uchio Yamada, Ken Fukumoto, Mika Suga, Satoshi Terada, et al. Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells. In vitro cellular & developmental biology. Animal. 2024
Koji Nakade, Satomi Tsukamoto, Kenichi Nakashima, Yuri An, Iori Sato, Jingyue Li, Yuzuno Shimoda, Yasuko Hemmi, Yoshihiro Miwa, Yohei Hayashi. Efficient selection of knocked-in pluripotent stem cells using a dual cassette cellular elimination system. Cell reports methods. 2023. 3. 12. 100662-100662
Mika Takahi, Riko Taira, Jo Onozuka, Haruka Sunamura, Akiko Kondow, Koji Nakade, Kenichi Nakashima, Iori Sato, Yohei Hayashi, Chinmoy Patra, et al. Xenograft of human pluripotent stem cell-derived cardiac lineage cells on zebrafish embryo heart. Biochemical and biophysical research communications. 2023
Pyotr A Tyurin-Kuzmin, Yohei Hayashi, Konstantin Kulebyakin. Editorial: Functional heterogeneity of stem cells. Frontiers in cell and developmental biology. 2023. 11. 1179911-1179911
Yuzuno Shimoda, Nobuyuki Murakoshi, Haruka Mori, DongZhu Xu, Kazuko Tajiri, Yasuko Hemmi, Iori Sato, Michiya Noguchi, Yukio Nakamura, Yohei Hayashi, et al. Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation. Stem cell research. 2022. 62. 102793-102793

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MISC (3)：

Y. Hayashi, E. C. Hsiao, S. Sami, M. Lancero, C. R. Schlieve, T. Nguyen, K. Yano, A. Nagahashi, M. Ikeya, Y. Matsumoto, et al. BMP-SMAD-ID signaling axis supports reprogramming to pluripotency. MOLECULAR BIOLOGY OF THE CELL. 2012. 23
Hayashi Y, Hsiao E, Sami S, Lancero M, Schlieve C, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Asaka I, et al. BMP-SMAD-ID axis promotes reprogramming to pluripotency. 第10 回ISSCR(2012.6.14.横浜). 2012
Y. Hayashi, M. Furue, K. Ohnuma, M. Asashima. Laminin promotes differentiation of mouse embryonic stem cells in serum-free adherent monoculture. MECHANISMS OF DEVELOPMENT. 2005. 122. S129-S130

Books (5)：

動物実験代替法とNew approach methodologiesの開発・利用動向
シーエムシー出版 2023 ISBN:9784781317472
細胞培養・組織培養の技術
朝倉書店 2023 ISBN:9784254310962
細胞培養実習テキスト第2版
じほう 2020 ISBN:9784840752923
~医薬品・再生医療製品開発者・技術者のための~iPS細胞の最新技術開発
技術情報協会 2016
細胞培養・品質管理の基礎知識と細胞培養基材の利用・開発・評価の留意点
情報機構 2016

Lectures and oral presentations (6)：

iPS細胞における環状染色体の自己修復
(第16回日本再生医療学会総会 2017)
Structure-based Discovery of NANOG Variant with Enhanced Properties to Promote Self-Renewal and Reprogramming of Pluripotent Stem Cells
(第39回日本分子生物学会大会 2016)
光応答性材料を介した光照射によるiPS細胞の分化操作
(第8回TIAシンポジウム 2016)
Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells
(TERMIS (Tissue Engineering and Regenerative Medicine International Society) -AP (Asia & Pacific) 2016 2016)
転写因子の構造解析から多能性幹細胞・リプログラミング機構の解明へ
(生命の機能とかたち筑波大学&高エネルギー加速器研究機構第1回連携セミナー 2016)

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Education (3)：

2004 - 2009 The University of Tokyo Graduate School of Arts and Sciences Multi-Disciplinary Sciences Life Sciences
2000 - 2004 The University of Tokyo, College of Arts and Sciences
1997 - 2000 Okazaki High School

Professional career (1)：

Ph. D. (University of Tokyo)

Work history (7)：

2022/07 - 現在 University of Tsukuba School of Integrative and Global Majors Professor
2018/04 - 現在 RIKEN Bioresource Research Center Team Leader
2016/04 - 2018/03 University of Tsukuba Graduate School of Comprehensive Human Sciences Assistant Professor
2015/01 - 2015/03 Research Scientist at Gladstone Institute of Cardiovascular Disease
2014/07 - 2015/03 Postdoctoral Fellow Overseas, Japanese Society for Promoting Sciences

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Committee career (7)：

2023/04 - 現在バイオインダストリー協会バイオエンジニアリング研究会委員
2023/04 - 現在日本再生医療学会産業推進委員会委員
2018/11 - 現在日本再生医療学会代議員
2021/06 - 日本再生医療学会チームU45 メンバー
2021/04 - 日本組織培養学会理事

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Awards (10)：

2019/11 - The Science and technology Promotion Foundation of Ibaraki Tsukuba Encouragement Prize Young Researchers
2018/04 - 筑波大学筑波大学若手教員特別奨励賞
2018/04 - 文部科学省平成30年度科学技術分野の文部科学大臣表彰若手科学者賞
2017/12 - 筑波大学若手教員奨励賞
2014/01 - 7th Takeda Science Foundation Symposium on PharmaScience Excellent Poster Award, 7th Takeda Science Foundation Symposium on PharmaScience

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Association Membership(s) (6)：

バイオインダストリー協会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE TISSUE CULTURE ASSOCIATION , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , International Society for Stem Cell Research (ISSCR) , Tissue Engineering and Regenerative Medicine International Society (TERMIS)

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